Link between cow's milk and breast cancer [View all]

[Maraya1969]

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6573940/

Objectives
Associations between diet and risk of breast cancer have been difficult to identify. Dairy milk has been hypothesized as a possible cause based on ecological data, also its sex hormone content (70% of dairy cows are pregnant), and likely ability to raise levels of insulin-like growth factor-1. We tested the dairy-breast cancer hypothesis in the Adventist Health Study-2 (AHS-2) cohort.

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Results
Comparing 90th to 10th percentiles of intake, dairy milk was associated with a hazard ratio (HR) of 1.41 (95% CI: 1.15–1.72; P = 0.001), rising to 2.56 (95% CI:1.51–4.99; P < 0.001) with the less biased but less precise regression calibration procedure. Models substituting median intakes of soymilk for dairy milk (medians of users) predicted a HR of 0.66 (95% CI:0.51–0.85; P < 0.001). No associations were seen with cheese or yogurt. Associations were non-linear with steeper rises in breast cancer risk at intakes of dairy milk up to ¾ cup/day. No clear indication of protection was seen for soymilk after adjustment for dairy.

Conclusions
In this population, dairy milk consumption is clearly associated with risk of breast cancer after adjusting for soy intake. This was not the case for cheese (known to have lower hormone content). More work is needed to define possible mechanisms. Those at higher risk of breast cancer may gain advantage by limiting milk intake and considering dairy substitutes.