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friendly_iconoclast
friendly_iconoclast's Journal
friendly_iconoclast's Journal
March 29, 2019
https://www.ncbi.nlm.nih.gov/pubmed/28067231
Multiomics reveal non-alcoholic fatty liver disease in rats following chronic exposure to an ultra-low dose of Roundup herbicide.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120931/
Reply to ‘Comments on two recent publications on GM maize and Roundup’
Gun deaths are quick and obvious. Roundup-induced cancer, kidney & liver damage are slow and hidden
Monsanto might still pull ahead. FWIW, I despise the NRA and Bayer/Monsanto equally
Note:emphasis added
https://www.google.com/search?ei=io6dXI-DKMGMggf5zJy4AQ&q=%22kidney+disease%22+poor+farmers+site%3Ademocraticunderground.com&oq=%22kidney+disease%22+poor+farmers+site%3Ademocraticunderground.com&gs_l=psy-ab.12...0.0..4714...0.0..0.0.0.......0......gws-wiz.FkYm_85Wtbs
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549093/
Transcriptome profile analysis reflects rat liver and kidney damage following chronic ultra-low dose Roundup exposure
Background
Glyphosate-based herbicides (GBH) are the major pesticides used worldwide. Converging evidence suggests that GBH, such as Roundup, pose a particular health risk to liver and kidneys although low environmentally relevant doses have not been examined. To address this issue, a 2-year study in rats administering 0.1 ppb Roundup (50 ng/L glyphosate equivalent) via drinking water (giving a daily intake of 4 ng/kg bw/day of glyphosate) was conducted. A marked increased incidence of anatomorphological and blood/urine biochemical changes was indicative of liver and kidney structure and functional pathology. In order to confirm these findings we have conducted a transcriptome microarray analysis of the liver and kidneys from these same animals.
Results
The expression of 4224 and 4447 transcript clusters (a group of probes corresponding to a known or putative gene) were found to be altered respectively in liver and kidney (p?<?0.01, q?<?0.08). Changes in gene expression varied from ?3.5 to 3.7 fold in liver and from ?4.3 to 5.3 in kidneys. Among the 1319 transcript clusters whose expression was altered in both tissues, ontological enrichment in 3 functional categories among 868 genes were found. First, genes involved in mRNA splicing and small nucleolar RNA were mostly upregulated, suggesting disruption of normal spliceosome activity. Electron microscopic analysis of hepatocytes confirmed nucleolar structural disruption. Second, genes controlling chromatin structure (especially histone-lysine N-methyltransferases) were mostly upregulated. Third, genes related to respiratory chain complex I and the tricarboxylic acid cycle were mostly downregulated. Pathway analysis suggests a modulation of the mTOR and phosphatidylinositol signalling pathways. Gene disturbances associated with the chronic administration of ultra-low dose Roundup reflect a liver and kidney lipotoxic condition and increased cellular growth that may be linked with regeneration in response to toxic effects causing damage to tissues. Observed alterations in gene expression were consistent with fibrosis, necrosis, phospholipidosis, mitochondrial membrane dysfunction and ischemia, which correlate with and thus confirm observations of pathology made at an anatomical, histological and biochemical level.
Conclusion
Our results suggest that chronic exposure to a GBH in an established laboratory animal toxicity model system at an ultra-low, environmental dose can result in liver and kidney damage with potential significant health implications for animal and human populations.
Glyphosate-based herbicides (GBH) are the major pesticides used worldwide. Converging evidence suggests that GBH, such as Roundup, pose a particular health risk to liver and kidneys although low environmentally relevant doses have not been examined. To address this issue, a 2-year study in rats administering 0.1 ppb Roundup (50 ng/L glyphosate equivalent) via drinking water (giving a daily intake of 4 ng/kg bw/day of glyphosate) was conducted. A marked increased incidence of anatomorphological and blood/urine biochemical changes was indicative of liver and kidney structure and functional pathology. In order to confirm these findings we have conducted a transcriptome microarray analysis of the liver and kidneys from these same animals.
Results
The expression of 4224 and 4447 transcript clusters (a group of probes corresponding to a known or putative gene) were found to be altered respectively in liver and kidney (p?<?0.01, q?<?0.08). Changes in gene expression varied from ?3.5 to 3.7 fold in liver and from ?4.3 to 5.3 in kidneys. Among the 1319 transcript clusters whose expression was altered in both tissues, ontological enrichment in 3 functional categories among 868 genes were found. First, genes involved in mRNA splicing and small nucleolar RNA were mostly upregulated, suggesting disruption of normal spliceosome activity. Electron microscopic analysis of hepatocytes confirmed nucleolar structural disruption. Second, genes controlling chromatin structure (especially histone-lysine N-methyltransferases) were mostly upregulated. Third, genes related to respiratory chain complex I and the tricarboxylic acid cycle were mostly downregulated. Pathway analysis suggests a modulation of the mTOR and phosphatidylinositol signalling pathways. Gene disturbances associated with the chronic administration of ultra-low dose Roundup reflect a liver and kidney lipotoxic condition and increased cellular growth that may be linked with regeneration in response to toxic effects causing damage to tissues. Observed alterations in gene expression were consistent with fibrosis, necrosis, phospholipidosis, mitochondrial membrane dysfunction and ischemia, which correlate with and thus confirm observations of pathology made at an anatomical, histological and biochemical level.
Conclusion
Our results suggest that chronic exposure to a GBH in an established laboratory animal toxicity model system at an ultra-low, environmental dose can result in liver and kidney damage with potential significant health implications for animal and human populations.
https://www.ncbi.nlm.nih.gov/pubmed/28067231
Multiomics reveal non-alcoholic fatty liver disease in rats following chronic exposure to an ultra-low dose of Roundup herbicide.
Abstract
The impairment of liver function by low environmentally relevant doses of glyphosate-based herbicides (GBH) is still a debatable and unresolved matter. Previously we have shown that rats administered for 2 years with 0.1 ppb (50?ng/L glyphosate equivalent dilution; 4?ng/kg body weight/day daily intake) of a Roundup GBH formulation showed signs of enhanced liver injury as indicated by anatomorphological, blood/urine biochemical changes and transcriptome profiling. Here we present a multiomic study combining metabolome and proteome liver analyses to obtain further insight into the Roundup-induced pathology. Proteins significantly disturbed (214 out of 1906 detected, q?<?0.05) were involved in organonitrogen metabolism and fatty acid ?-oxidation. Proteome disturbances reflected peroxisomal proliferation, steatosis and necrosis. The metabolome analysis (55 metabolites altered out of 673 detected, p?<?0.05) confirmed lipotoxic conditions and oxidative stress by showing an activation of glutathione and ascorbate free radical scavenger systems. Additionally, we found metabolite alterations associated with hallmarks of hepatotoxicity such as ?-glutamyl dipeptides, acylcarnitines, and proline derivatives. Overall, metabolome and proteome disturbances showed a substantial overlap with biomarkers of non-alcoholic fatty liver disease and its progression to steatohepatosis and thus confirm liver functional dysfunction resulting from chronic ultra-low dose GBH exposure.
The impairment of liver function by low environmentally relevant doses of glyphosate-based herbicides (GBH) is still a debatable and unresolved matter. Previously we have shown that rats administered for 2 years with 0.1 ppb (50?ng/L glyphosate equivalent dilution; 4?ng/kg body weight/day daily intake) of a Roundup GBH formulation showed signs of enhanced liver injury as indicated by anatomorphological, blood/urine biochemical changes and transcriptome profiling. Here we present a multiomic study combining metabolome and proteome liver analyses to obtain further insight into the Roundup-induced pathology. Proteins significantly disturbed (214 out of 1906 detected, q?<?0.05) were involved in organonitrogen metabolism and fatty acid ?-oxidation. Proteome disturbances reflected peroxisomal proliferation, steatosis and necrosis. The metabolome analysis (55 metabolites altered out of 673 detected, p?<?0.05) confirmed lipotoxic conditions and oxidative stress by showing an activation of glutathione and ascorbate free radical scavenger systems. Additionally, we found metabolite alterations associated with hallmarks of hepatotoxicity such as ?-glutamyl dipeptides, acylcarnitines, and proline derivatives. Overall, metabolome and proteome disturbances showed a substantial overlap with biomarkers of non-alcoholic fatty liver disease and its progression to steatohepatosis and thus confirm liver functional dysfunction resulting from chronic ultra-low dose GBH exposure.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120931/
Reply to ‘Comments on two recent publications on GM maize and Roundup’
The opinion expressed by Eriksson and colleagues’ fails to recognise that there are no standard experimental designs for academic investigations involving omics analyses of genetically modified crops and that the only valid comparator to determine the effect of the process of transgenesis is a near isogenic variety grown at the same time and location, as was the case in our investigation of NK603 maize. Eriksson does not acknowledge that the quality of the rat liver tissues in our chronic Roundup toxicity study has neither been questioned nor branded as unsuitable for further investigation. In addition, Eriksson fails to appreciate that the statistical methods we used to analyse the liver metabolomics dataset are recognised as appropriate as some of a number of approaches that can be taken. Moreover, Eriksson neglects to mention that the proteomics analysis of the liver tissues highlights structural and functional damage from Roundup exposure. Thus our results are sound and the claims by Eriksson and colleagues of experimental flaws are unfounded.Replying to: Eriksson et al. Sci Rep 8 (2018); 10.1038/s41598-018-30440-7.
March 27, 2019
https://www.democraticunderground.com/1172133670
https://upload.democraticunderground.com/1172160038#post5
Response to gejohnston (Reply #5)
Thu Jan 29, 2015, 10:57 AM
One supposes Purdue Pharma and Takata weren't hiring at the time...
Who has helped to kill more people: Monsanto or the NRA?
And how much of what's descibed at the first link the responsibility of former glyphoste shill Shannon Watts?
https://www.democraticunderground.com/1127125363
U.S. jury hits Bayer with $81 million in Roundup cancer trial
Source: Reuters
BUSINESS NEWS MARCH 27, 2019 / 6:05 PM / UPDATED 16 MINUTES AGO
U.S. jury hits Bayer with $81 million in Roundup cancer trial
(Reuters) - A U.S. jury on Wednesday awarded $80.9 million to a man who claimed his use of Bayer AG’s glyphosate-based weed killer Roundup caused his cancer, in the latest legal setback for the company facing thousands of similar lawsuits.
The jury in San Francisco federal court said the company was liable for plaintiff Edwin Hardeman’s non-Hodgkin’s lymphoma.
Reporting by Alexandria Sage in San Francisco; editing by Bill Berkrot
https://www.reuters.com/article/us-bayer-glyphosate-lawsuit/u-s-jury-hits-bayer-with-81-million-in-roundup-cancer-trial-idUSKCN1R
Source: Reuters
BUSINESS NEWS MARCH 27, 2019 / 6:05 PM / UPDATED 16 MINUTES AGO
U.S. jury hits Bayer with $81 million in Roundup cancer trial
(Reuters) - A U.S. jury on Wednesday awarded $80.9 million to a man who claimed his use of Bayer AG’s glyphosate-based weed killer Roundup caused his cancer, in the latest legal setback for the company facing thousands of similar lawsuits.
The jury in San Francisco federal court said the company was liable for plaintiff Edwin Hardeman’s non-Hodgkin’s lymphoma.
Reporting by Alexandria Sage in San Francisco; editing by Bill Berkrot
https://www.reuters.com/article/us-bayer-glyphosate-lawsuit/u-s-jury-hits-bayer-with-81-million-in-roundup-cancer-trial-idUSKCN1R
https://www.democraticunderground.com/1172133670
https://upload.democraticunderground.com/1172160038#post5
5. the difference is,
she is the whole group. Bloomberg hired her firm, Popvox Public Relations LLC, to create an astro turf group to be the "MADD" of guns. A month before their creation, Bloomberg and his staff were using NYC government email to discuss how to create it. Someone filed a city equivalent to a FOIA, and got the whole dump.
The few protesters who show up might be "likes" on Facebook, or paid employees. The armed body guards at these events are certainly paid.
Since Watts is speaking as a Bloomberg employee, she is speaking for Bloomberg. Since she is MDA, she is also speaking for it.
Oh yes, she really was the PR chief for Monsanto, you know the "Round up is harmless" people...
she is the whole group. Bloomberg hired her firm, Popvox Public Relations LLC, to create an astro turf group to be the "MADD" of guns. A month before their creation, Bloomberg and his staff were using NYC government email to discuss how to create it. Someone filed a city equivalent to a FOIA, and got the whole dump.
The few protesters who show up might be "likes" on Facebook, or paid employees. The armed body guards at these events are certainly paid.
Since Watts is speaking as a Bloomberg employee, she is speaking for Bloomberg. Since she is MDA, she is also speaking for it.
Oh yes, she really was the PR chief for Monsanto, you know the "Round up is harmless" people...
Response to gejohnston (Reply #5)
Thu Jan 29, 2015, 10:57 AM
DonP (6,185 posts)
8. FWIW, she also worked on the "GMO foods are good for your children" campaign
So obviously we can all trust her, since I'm sure she feeds her children GMO Veggies every day and probably resents having armed guards following her to events.
But to control "fans" I guess armed guards are not really hypocrisy, that's just more proof of how "dangerous" those gun owners are.
8. FWIW, she also worked on the "GMO foods are good for your children" campaign
So obviously we can all trust her, since I'm sure she feeds her children GMO Veggies every day and probably resents having armed guards following her to events.
But to control "fans" I guess armed guards are not really hypocrisy, that's just more proof of how "dangerous" those gun owners are.
One supposes Purdue Pharma and Takata weren't hiring at the time...
March 14, 2019
US official reveals Atlantic drilling plan while hailing Trump's ability to distract public
Repost from LBN:
https://upload.democraticunderground.com/10142285806
https://www.theguardian.com/environment/2019/mar/14/offshore-drilling-trump-official-reveals-plan-and-distractions-delight
Revealed: Interior department official says he is ‘thrilled’ by Trump’s ‘knack for keeping the attention of the media and public focused somewhere else’
A top US official told a group of fossil fuel industry leaders that the Trump administration will soon issue a proposal making large portions of the Atlantic available for oil and gas development, and said that it is easier to work on such priorities because Donald Trump is skilled at sowing “absolutely thrilling” distractions, according to records of a meeting obtained by the Guardian.
Joe Balash, the assistant secretary for land and minerals management, was speaking to companies in the oil exploration business at a meeting of the International Association of Geophysical Contractors, or IAGC, last month.
“One of the things that I have found absolutely thrilling in working for this administration,” said Balash,“is the president has a knack for keeping the attention of the media and the public focused somewhere else while we do all the work that needs to be done on behalf of the American people.”...
A top US official told a group of fossil fuel industry leaders that the Trump administration will soon issue a proposal making large portions of the Atlantic available for oil and gas development, and said that it is easier to work on such priorities because Donald Trump is skilled at sowing “absolutely thrilling” distractions, according to records of a meeting obtained by the Guardian.
Joe Balash, the assistant secretary for land and minerals management, was speaking to companies in the oil exploration business at a meeting of the International Association of Geophysical Contractors, or IAGC, last month.
“One of the things that I have found absolutely thrilling in working for this administration,” said Balash,“is the president has a knack for keeping the attention of the media and the public focused somewhere else while we do all the work that needs to be done on behalf of the American people.”...
March 14, 2019
SOSO from the LePetomaine/Burns Administration...
US official reveals Atlantic drilling plan while hailing Trump's ability to distract public
Source: Guardian (UK)
Revealed: Interior department official says he is ‘thrilled’ by Trump’s ‘knack for keeping the attention of the media and public focused somewhere else’
A top US official told a group of fossil fuel industry leaders that the Trump administration will soon issue a proposal making large portions of the Atlantic available for oil and gas development, and said that it is easier to work on such priorities because Donald Trump is skilled at sowing “absolutely thrilling” distractions, according to records of a meeting obtained by the Guardian.
Joe Balash, the assistant secretary for land and minerals management, was speaking to companies in the oil exploration business at a meeting of the International Association of Geophysical Contractors, or IAGC, last month.
“One of the things that I have found absolutely thrilling in working for this administration,” said Balash,“is the president has a knack for keeping the attention of the media and the public focused somewhere else while we do all the work that needs to be done on behalf of the American people.”...
Read more: https://www.theguardian.com/environment/2019/mar/14/offshore-drilling-trump-official-reveals-plan-and-distractions-delight
SOSO from the LePetomaine/Burns Administration...
March 12, 2019
ACLU: N. Carolinians Voted to End Cooperation With Trump's Deportation Force. ICE Retaliated
Repost from GD:
https://www.democraticunderground.com/100211913353
https://www.aclu.org/blog/immigrants-rights/ice-and-border-patrol-abuses/north-carolinians-voted-end-cooperation-trumps
Recent raids by U.S. Immigration and Customs Enforcement (ICE) in North Carolina were a failed attempt to achieve by force what was soundly rejected at the ballot box last November: Trump’s anti-immigrant agenda. ICE targeted places and people based on democratic decisions North Carolina counties made about their policing resources and values, including upholding the Constitution
Sweeping Change Across North Carolina
In the 2018 sheriffs’ elections in North Carolina, several long-term incumbents in Wake, Durham, Mecklenburg, Forsyth, and Henderson counties were defeated. Their successors ran — and won — on the promise of accountability to the diverse communities that they serve and against being part of Trump’s deportation force. This included the termination of 287(g) cooperation agreements with ICE that notify federal agents of the immigration status of detained individuals. Immediately, sheriffs began enacting the will of the people...
...ICE engaged in a five-day statewide operation in North Carolina starting Feb. 5. ICE targeted the three counties — Wake, Durham, and Mecklenburg — where sheriffs have publicly ended their collaboration with ICE...
...In defending the raids, ICE officials directed their ire at local law enforcement for ending collaboration with ICE. ICE Field Office Director Sean Gallagher named “the dangerous policies of not cooperating with ICE,” as the impetus for the operation.
Sweeping Change Across North Carolina
In the 2018 sheriffs’ elections in North Carolina, several long-term incumbents in Wake, Durham, Mecklenburg, Forsyth, and Henderson counties were defeated. Their successors ran — and won — on the promise of accountability to the diverse communities that they serve and against being part of Trump’s deportation force. This included the termination of 287(g) cooperation agreements with ICE that notify federal agents of the immigration status of detained individuals. Immediately, sheriffs began enacting the will of the people...
...ICE engaged in a five-day statewide operation in North Carolina starting Feb. 5. ICE targeted the three counties — Wake, Durham, and Mecklenburg — where sheriffs have publicly ended their collaboration with ICE...
...In defending the raids, ICE officials directed their ire at local law enforcement for ending collaboration with ICE. ICE Field Office Director Sean Gallagher named “the dangerous policies of not cooperating with ICE,” as the impetus for the operation.
March 12, 2019
ACLU: N. Carolinians Voted to End Cooperation With Trump's Deportation Force. ICE Retaliated.
https://www.aclu.org/blog/immigrants-rights/ice-and-border-patrol-abuses/north-carolinians-voted-end-cooperation-trumpsRecent raids by U.S. Immigration and Customs Enforcement (ICE) in North Carolina were a failed attempt to achieve by force what was soundly rejected at the ballot box last November: Trump’s anti-immigrant agenda. ICE targeted places and people based on democratic decisions North Carolina counties made about their policing resources and values, including upholding the Constitution
Sweeping Change Across North Carolina
In the 2018 sheriffs’ elections in North Carolina, several long-term incumbents in Wake, Durham, Mecklenburg, Forsyth, and Henderson counties were defeated. Their successors ran — and won — on the promise of accountability to the diverse communities that they serve and against being part of Trump’s deportation force. This included the termination of 287(g) cooperation agreements with ICE that notify federal agents of the immigration status of detained individuals. Immediately, sheriffs began enacting the will of the people...
...ICE engaged in a five-day statewide operation in North Carolina starting Feb. 5. ICE targeted the three counties — Wake, Durham, and Mecklenburg — where sheriffs have publicly ended their collaboration with ICE...
...In defending the raids, ICE officials directed their ire at local law enforcement for ending collaboration with ICE. ICE Field Office Director Sean Gallagher named “the dangerous policies of not cooperating with ICE,” as the impetus for the operation.
Sweeping Change Across North Carolina
In the 2018 sheriffs’ elections in North Carolina, several long-term incumbents in Wake, Durham, Mecklenburg, Forsyth, and Henderson counties were defeated. Their successors ran — and won — on the promise of accountability to the diverse communities that they serve and against being part of Trump’s deportation force. This included the termination of 287(g) cooperation agreements with ICE that notify federal agents of the immigration status of detained individuals. Immediately, sheriffs began enacting the will of the people...
...ICE engaged in a five-day statewide operation in North Carolina starting Feb. 5. ICE targeted the three counties — Wake, Durham, and Mecklenburg — where sheriffs have publicly ended their collaboration with ICE...
...In defending the raids, ICE officials directed their ire at local law enforcement for ending collaboration with ICE. ICE Field Office Director Sean Gallagher named “the dangerous policies of not cooperating with ICE,” as the impetus for the operation.
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