How Corn Syrup Might Be Making Us Hungry-and Fat [View all]

[QED]

I thought this was interesting - it offers some evidence about the adverse effects of HFCS that we've suspected was a significant factor in obesity. The bottom line is that fructose doesn't send a message that we're full but glucose does. Both sugars are present in equal amounts in the sucrose molecule but there's more fructose in HFCS so its effect is enhanced.

How Corn Syrup Might Be Making Us Hungry-and Fat

Grocery store aisles are awash in foods and beverages that contain high-fructose corn syrup. It is common in sodas and crops up in everything from ketchup to snack bars. This cheap sweetener has been an increasingly popular additive in recent decades and has often been fingered as a driver of the obesity epidemic.

These fears may be well founded. Fructose, a new study finds, has a marked affect on the brain region that regulates appetite, suggesting that corn syrup and other forms of fructose might encourage over-eating to a greater degree than glucose. Table sugar has both fructose and glucose, but high-fructose corn syrup, as the name suggests, contains a higher proportion of fructose.

To test how fructose affects the brain, researchers studied 20 healthy adult volunteers. While the test subjects consumed sweetened beverages, the researchers used fMRIs (functional magnetic resonance imaging) to measure the response of the hypothalamus, which helps regulate many hunger-related signals, as well as reward and motivation processing.

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Subjects showed substantial differences in their hypothalamic activity after consuming the fructose-sweetened beverage versus the one sweetened by glucose within 15 minutes. Glucose lowered the activity of the hypothalamus but fructose actually prompted a small spike to this area. As might be expected from these results, the glucose drink alone increased the feelings of fullness reported by volunteers, which indicates that they would be less likely to consume more calories after having something sweetened with glucose than something sweetened with more fructose.

More:

http://news.yahoo.com/corn-syrup-might-making-us-hungry-fat-210000069.html

JAMA article abstract:

http://jama.jamanetwork.com/article.aspx?articleid=1555133