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WilliamPitt Donating Member (1000+ posts) Send PM | Profile | Ignore Tue Feb-17-09 02:45 PM
Original message
Getting Well (on Pres. Obama lifting the embryonic stem cell ban)
Edited on Tue Feb-17-09 02:47 PM by WilliamPitt
Personal note: my fiancee has MS, so this is a big fat huge deal in my house. There were three or four main pillar issues that motivated me to vote for this guy twice last year. Embryonic stem cell research is one of them.

===



Researchers use stem cells to encourage growth of a new organ. (Photo: Max Aguilera-Hellweg, M.D. / National Geographic)

Getting Well
By William Rivers Pitt
t r u t h o u t | Columnist

Tuesday 17 February 2009

In the beginning there is the stem cell; it is the origin of an organism's life. It is a single cell that can give rise to progeny that differentiate into any of the specialized cells of embryonic or adult tissues.

- Stewart Sell, M.D., Senior Scientist, Ordway Research Institute


The Obama administration won its way through to passage of the economic stimulus package, and President Obama will sign the thing on Tuesday. On Wednesday, he's going to Phoenix to kick off a big national push for fixing the foreclosure crisis. There is still a war going on in Afghanistan, and there is still a war going on in Iraq. The White House has wisely decided to stay away from the question of Karl Rove's subpoena and the limits of Bush-era executive privilege claims; the issue is one of separation of powers, and therefore must be handled by the legislative and judicial branches, so the executive branch doesn't wind up getting to determine the limits of its own power.

So there's a lot of galactically heavy stuff going on right now, with more sure to come.

But there's also this, from The Associated Press on Sunday afternoon:

President Barack Obama will soon issue an executive order lifting an eight-year ban on embryonic stem cell research imposed by his predecessor, President George W. Bush, a senior adviser said on Sunday. "We're going to be doing something on that soon, I think. The president is considering that right now," Obama adviser David Axelrod said on "Fox News Sunday."

In 2001, Bush limited federal funding for stem cell research only to human embryonic stem cell lines that already existed. It was a gesture to his conservative Christian supporters who regard embryonic stem cell research as destroying potential life, because the cells must be extracted from human embryos. Embryonic stem cells are the most basic human cells which can develop into any type of cell in the body.

Scientists believe the research could eventually produce cures for a variety of diseases, including Parkinson's disease, diabetes, heart disease and spinal cord injuries. Obama vowed to reverse Bush's ban during his presidential campaign, and in his inaugural address last month promised to return science to its proper place in the United States.


The National Institutes of Health (NIH) describes cells this way: "Stem cells have two important characteristics that distinguish them from other types of cells. First, they are unspecialized cells that renew themselves for long periods through cell division. The second is that under certain physiologic or experimental conditions, they can be induced to become cells with special functions such as the beating cells of the heart muscle or the insulin-producing cells of the pancreas. Stem cells are important for living organisms for many reasons. In the 3- to 5-day-old embryo, called a blastocyst, stem cells in developing tissues give rise to the multiple specialized cell types that make up the heart, lung, skin and other tissues. In some adult tissues, such as bone marrow, muscle and brain, discrete populations of adult stem cells generate replacements for cells that are lost through normal wear and tear, injury or disease."

The CDC estimated in 2008 that 24 million Americans suffered from diabetes, 5.7 million of them currently undiagnosed. Fifty-seven million more Americans are estimated to have pre-diabetes. The National Center for Chronic Disease Prevention and Health Promotion estimates one in three Americans born after 2000 will develop diabetes sometime within their lifetime. Complications from diabetes include a doubled risk of cardiovascular disease, renal failure, retinal damage and blindness, various kinds of nerve damage and poor wound healing that can lead to gangrene and potentially to amputation. Diabetes is the leading cause of adult blindness in non-elderly persons and the leading cause of non-traumatic amputation in adults. Diabetes is also the main illness requiring renal dialysis in the United States.

Parkinson's disease affects half a million Americans, with 50,000 new cases reported every year. The four primary symptoms are tremor or trembling in hands, arms, legs, jaw and face; rigidity or stiffness of the limbs and trunk, slowness of movement and/or impaired balance and coordination. Patients can have difficulty walking, talking or doing other simple tasks. This chronic disease persists over a long period and is progressive, meaning symptoms grow worse over time. Other symptoms accompanying Parkinson's disease include depression or other emotional changes, difficulty swallowing and chewing, blurred or slurring speech, urinary problems or constipation, and sleep problems.

Multiple sclerosis affects approximately 400,000 Americans, with roughly 10,000 new cases diagnosed every year. MS patients suffer from a wide variety of neurological symptoms, including changed sensations, weakness of muscles, spasms, difficulty with moving, coordination and balance, problems in speech, swallowing, vision, fatigue, acute and/or chronic pain, and bladder and bowel control difficulties. Mental and emotional impairment and depression are also common. Multiple sclerosis relapses or attacks are unpredictable, and can occur without warning or obvious inciting factors.

ALS, or Lou Gehrig's Disease, affects as many as 30,000 Americans. Patients with ALS will eventually not be able to stand, walk or use their hands and arms. Difficulty swallowing and chewing impair the patient's ability to eat normally and increase the risk of choking. ALS usually does not affect the mental faculties, so patients are vividly aware of their loss of function and can become anxious and depressed. As the diaphragm and intercostal muscles weaken, breathing difficulties increase. ALS patients must eventually decide whether to have a tracheostomy and long-term mechanical ventilation. Most people with ALS die of respiratory failure or pneumonia, not the disease itself.

Approximately 5.3 million Americans suffer from some form of brain injury. Cancer is responsible for 25 percent of all deaths in America. Half of all men and one-third of all women in America will develop cancer during their lifetimes. More than half a million Americans suffer from blindness. Hundreds of millions of people in every nation on Earth suffer from all these conditions.

Stem cell research has great potential to treat, or even cure, many of these maladies, and many more besides. The story behind why America has not pursued stem cell research with the level of vigor the possibilities would seem to demand is long and politically convoluted, but basically boils down to this: a small but vocal minority in the country believe stem cell research is baby butchery akin to legalized abortion, and for the last eight years a president who agreed, or simply didn't want to tick that small minority off, was in office. A lot of other politicians who should have known better heard words like "snowflake babies" and "abortion" and ran like rabbits, and thus America's pursuit of this astonishing medical breakthrough has been stuck in the mud.

Not for much longer.

Millions of Americans and hundreds of millions more worldwide who have been afflicted by these terrible maladies can actually begin to imagine what once seemed impossible: getting well. They can dream of the incurable becoming cured. They can hope.

Welcome, at last, to the 21st century.

http://www.truthout.org/021709A
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IDemo Donating Member (1000+ posts) Send PM | Profile | Ignore Tue Feb-17-09 02:50 PM
Response to Original message
1. After 50,000 insulin injections, I'm ready
"Welcome, at last, to the 21st century." Too bad we had to endure the 15th Century for so long to get here.
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SCantiGOP Donating Member (1000+ posts) Send PM | Profile | Ignore Wed Feb-18-09 04:31 PM
Response to Reply #1
24. Amen to that
My beautiful, talented daughter is 11 and has been diabetic for almost 6 years. She's on a pump, but whenever she checks in with a blood sugar over 200 I know some type of damage is being done to her. When she was diagnosed and heard the doctor say the word die-uh-bee-tees she asked, "Am I going to die?" I promised her a cure in ten years (knowing that Bush would lose in 2004) and I've only got till 2013 to keep my promise.
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Dulcinea Donating Member (1000+ posts) Send PM | Profile | Ignore Wed Feb-18-09 05:05 PM
Response to Reply #1
25. My sister is a type 1 diabetic.
Welcome to the 21st century, indeed!
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Joe Fields Donating Member (1000+ posts) Send PM | Profile | Ignore Tue Feb-17-09 03:14 PM
Response to Original message
2. I know about your fiance, Will. I am happy for your fiance, you, her family and yours.
I'm also hopeful for millions of others who had lost a lot of hope over the last eight years.

This Obama guy ain't half bad.
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JeffR Donating Member (1000+ posts) Send PM | Profile | Ignore Tue Feb-17-09 03:27 PM
Response to Original message
3. K & R.
This is great news.

Added bonus, it's going to piss off the religious right something fierce.

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Cha Donating Member (1000+ posts) Send PM | Profile | Ignore Tue Feb-17-09 07:34 PM
Response to Reply #3
18. The religious hypocrites...
who never did anything for their country.
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Shakespeare Donating Member (1000+ posts) Send PM | Profile | Ignore Tue Feb-17-09 03:30 PM
Response to Original message
4. K&R. My sister has rheumatoid arthritis, so I share your feelings on this.
Time to get to work.
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Kurovski Donating Member (1000+ posts) Send PM | Profile | Ignore Tue Feb-17-09 03:49 PM
Response to Original message
5. K&R.
Here's hoping to the TRULY new American Century.

May the regressive Republican Party remain in the minority for this century's entirety.
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ejpoeta Donating Member (1000+ posts) Send PM | Profile | Ignore Tue Feb-17-09 03:54 PM
Response to Original message
6. my 2 cents
Anyone who is against stem cell research should not ever have a blood transfusion, vaccine, any medications or treatments for any illness.... why, you ask? because there was a time when people had to dig up corpses to study the human body to learn about how it worked to create medical treatments and advances in illnesses and such. This was seen as very bad. it had to be done in secret because people would get in trouble. We would not have the ability to understand or treat diseases and illnesses without such things. and those who are not willing to support advances should not benefit from science and medicine. period.
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WilliamPitt Donating Member (1000+ posts) Send PM | Profile | Ignore Tue Feb-17-09 04:47 PM
Response to Original message
7. .
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newtothegame Donating Member (1000+ posts) Send PM | Profile | Ignore Tue Feb-17-09 04:52 PM
Response to Original message
8. Does anybody know why they focus on embryonic stem cells instead of cord blood cells?
Seems to me you could avoid the controversy.
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FedUpWithIt All Donating Member (1000+ posts) Send PM | Profile | Ignore Tue Feb-17-09 07:16 PM
Response to Reply #8
17. I donated cord blood when my son was born and it was accepted.
It makes me happy to think that this might be helping someone.

I have no personal issue with embryonic stem cells as they are usually frozen leftovers from fertility treatments. I think the issue here is that embryonic stem cells may provide more windows for advancement in medicine than has been possible with either cord or adult stem cells. Amniotic stem cells were showing great potential (more viable than embryonic stem cells) but only got press for a short time...

http://www.washingtonpost.com/wp-dyn/content/article/2007/01/07/AR2007010700674.html

:shrug:

I feel Obama made the right decision with lifting the ban. These embryos are excess cells that would be discarded after a round of fertility treatment (where is the ethical debate about this?). People's suffering could possibly be relieved. It is a do the least harm issue here.
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Horse with no Name Donating Member (1000+ posts) Send PM | Profile | Ignore Tue Feb-17-09 08:24 PM
Response to Reply #8
22. Here you go (best explanation I can find)
http://www.pregnancy-info.net/StemCell/embryonic_adult.html
>>>snip
The first cord blood transplant was performed in 1988, and has spurred a flurry of activity in the area. Umbilical cord blood has many benefits that bone marrow transplants and peripheral blood stem cells lack. It's painless to extract, and once it's banked, it's readily available for transplant needs. There are a host of diseases that cord blood can treat, making it a leader in cell-based regenerative therapy. Because it's a source of more primitive stem cells, there is a lower risk of GVHD. Because of this lower risk, it is possible to treat patients with less perfect HLA (Human Leukocyte Antigens) matches.
>>>>snip
While cord blood is technically an 'adult' or 'somatic' stem cell source, it is often distinguished from the adult stem cell category. Because cord blood is a source of younger stem cells, it looms somewhere between adult stem cells and embryonic stem cells, offering the benefits of each category.

>>>snip
Embryonic stem cells have the capacity to replicate themselves, a process called proliferation. At about six months, cultured embryonic stem cells have created millions of new stem cells. Embryonic stem cells can proliferate for a year or more in the laboratory.

With those countless stem cells, scientists have the potential ability to create various specialized cells. This is because embryonic stem cells are pluripotent, or they have the ability to transform into virtually any cell. Ideally, these specialized cells will be able to treat a number of diseases and disorders in the future including diabetes, Parkinson's disease, heart disease, spinal cord injuries and vision and hearing loss.
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Norrin Radd Donating Member (1000+ posts) Send PM | Profile | Ignore Tue Feb-17-09 04:56 PM
Response to Original message
9. kr
We could've had a decade of advancement in this area.
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Baikonour Donating Member (979 posts) Send PM | Profile | Ignore Tue Feb-17-09 05:04 PM
Response to Original message
10. Hmm..
"Half of all men and one-third of all women in America will develop cancer during their lifetimes."

I'd really like to see some stats and figures that confirm this, please.
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WilliamPitt Donating Member (1000+ posts) Send PM | Profile | Ignore Tue Feb-17-09 05:05 PM
Response to Reply #10
11. Here
Edited on Tue Feb-17-09 05:09 PM by WilliamPitt
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Baikonour Donating Member (979 posts) Send PM | Profile | Ignore Tue Feb-17-09 08:13 PM
Response to Reply #11
19. If it is indeed true
Those are some horribly frightening statistics.
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mntleo2 Donating Member (1000+ posts) Send PM | Profile | Ignore Tue Feb-17-09 05:10 PM
Response to Original message
12. Diabetic Here!
...it seems to run in especially Irish, Native American and African American people and I guess I got the "Irish" part. My grandmother had diabetes, her son, my dad, his sister and my aunt, my sister and myself. My aunt, sister, and I are still alive, but the rest are gone due to diabetes complications. It is not fun. Lord I would love it if they found something to help us with stem cell therapy!

Cat In Seattle
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annabanana Donating Member (1000+ posts) Send PM | Profile | Ignore Tue Feb-17-09 05:30 PM
Response to Original message
13. May all the promise in this research reach fruition. . .k&r . . .n/t
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Career Prole Donating Member (1000+ posts) Send PM | Profile | Ignore Tue Feb-17-09 06:24 PM
Response to Original message
14. My big sister suffers from MS too, Will.
Here's to finding answers!
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Demoiselle Donating Member (1000+ posts) Send PM | Profile | Ignore Tue Feb-17-09 07:00 PM
Response to Original message
15. I'm entirely with you, Will
Perhaps the thing I most love and respect about mankind is our ( its?) curiosity about the world and what makes it work. To think that we have had eight years of religious taboo preventing scientists in this country from exploring the possibilities of embrionic stem cells makes me furious. We ALL have a personal stake in this.
My very best wishes to you, your family, your fiancee. Thank you for all the good, intelligent work you give us.
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firedupdem Donating Member (1000+ posts) Send PM | Profile | Ignore Tue Feb-17-09 07:14 PM
Response to Original message
16. K & R! Thank you for this information and
hugs to your fiancee.
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wellstone dem Donating Member (1000+ posts) Send PM | Profile | Ignore Tue Feb-17-09 08:18 PM
Response to Original message
20. k and r for my nephew
diagnosed with diabetes at age 10, 4 years ago.
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Baikonour Donating Member (979 posts) Send PM | Profile | Ignore Tue Feb-17-09 08:20 PM
Response to Original message
21. My mother has M.S.
News like this bring her and I a lot of hope, and we are grateful to Obama and those whom helped him pass this legislation.
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WilliamPitt Donating Member (1000+ posts) Send PM | Profile | Ignore Wed Feb-18-09 07:48 AM
Response to Original message
23. One more kick
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WePurrsevere Donating Member (1000+ posts) Send PM | Profile | Ignore Thu Feb-19-09 09:51 AM
Response to Original message
26. Well said.. thank you, Will. Hope is a wonderful word isn't it? This Spring it will be 21 yrs....
Edited on Thu Feb-19-09 09:52 AM by WePurrsevere
since I was DXd with MS. I remember it very well, it was on my birthday.

Even knowing Obama had said he would lift the ban I sat here and cried when I read that he was really going to do it... the feeling of relief and hope was simply overwhelming.

Growing up with a mother who was a diabetic and had heart disease I've lived most of my life with the hope that there would be a cure for most diseases in my lifetime and stem cell research is the area I feel has the most potential. I've lost friends and loved ones to; MS, cancer, heart disease, diabetes and Alz. I have living friends and family that have diseases this research might help someday and grandchildren that could live longer and more productive lives because of this research.

It goes beyond my comprehension how the statistically very vague potential for a human life is more important to this relatively small group of people then one that already exists and is a very much alive, breathing, caring human being who is suffering from diseases that could be cured so they could live longer and more productive lives.

From their stance on stem cells, research, climate change, wars & benefits (for veterans, disabled, seniors, sick, unemployed, poor, etc), it's become increasingly obvious that many Republicans care more about sucking up to their "Fundie" base and money then actually doing things that HELP the MILLIONS of LIVING breathing human beings with both with quality and quantity of life.
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