Reply #22: if you want to be senator from Mass., yes

[Retrograde]

Article I Section 3:
"No person shall be a Senator who shall not have attained to the Age of thirty Years, and been nine Years a Citizen of the United States, and who shall not, when elected, be an Inhabitant of that State for which he shall be chosen."

Now, resident is an ill-defined term, and there have been cases of people moving to a state mainly to run for senator - Robert Kennedy, for example, who when elected didn't meet New York's residency requirements to vote for himself.

By my feeble understanding of the law, Caroline Kennedy could decide to change her principal residence to her Massachusetts property and try for senate from there.