Reply #8: I see two existential issues...

[CantGetFooledAgain]

Climate change, and the threat of nuclear war or nuclear terrorism. Both threaten the earth, and as such are the highest priorities.

That being said, everything on this list is of critical importance in its own way.

I think that "Tax Reform", done correctly, is the most effective way to cure "The Economy".

And if we don't fix the election system, we're basically left without any hope of changing any of the other stuff.

Tough call.