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octoberlib

(14,971 posts)
Fri Mar 27, 2020, 06:57 AM Mar 2020

Good news on the 206 antibodies scientists isolated from 8 COVID patients [View all]


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Study of 206 monoclonal antibodies against #SARSCoV2 isolated from 8 #COVID19 patients. Some antibody clones are highly effective at neutralizing live SARS-CoV-2 virus in cells, suggesting that we now know human antibody sequences that would be effective COVID-19 drugs.

In addition, the authors observed interesting cross-reactivity of antibodies against SARS-CoV & MERS-CoV trimeric spike protein, but not against SARS-CoV & MERS-CoV spike receptor-binding domain, suggesting unusual antibody response viral specificity (2/2) biorxiv.org/content/10.110…

Yes, very good news. There are now multiple reports of monoclonal (we know exactly which protein sequence needs to be manufactured) human (should be quite safe as drugs) antibodies that block the #SARSCoV2 virus that causes #COVID19. Same strategy as was used to treat Ebola.




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Annotated table of current #COVID19 #COVID2019 therapeutics and vaccines in development, listing developer, clinical phase, timing, & sources, assembled by the @MilkenInstitute. Current tally: 71 therapeutics in development, and 47 vaccines in development. milkeninstitute.org/sites/default/…


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So the paper is here. The abstract reads: Ghost Dog Mar 2020 #1
Yaaaaay! SheltieLover Mar 2020 #5
great news!! subana Mar 2020 #2
Since none of that makes sense to me, i'm happy to see you say "great news"! oldsoftie Mar 2020 #4
This is the path toward making a "biological" greymattermom Mar 2020 #9
LOL Lulu KC Mar 2020 #15
just to be clear subana Mar 2020 #40
Good! Thank you oldsoftie Mar 2020 #41
you're welcome... subana Mar 2020 #42
+1 Demovictory9 Mar 2020 #44
trump Dios Mio Mar 2020 #11
& total BS! subana Mar 2020 #39
He will try to take credit for it. Doodley Mar 2020 #54
From the sounds of it this is superb. a la izquierda Mar 2020 #3
I see a tiny teeny MFM008 Mar 2020 #6
Hurry, hospital workers are entering a phase of high danger and risk. magicarpet Mar 2020 #7
Not to rain on the parade, but it is a long distance between sequencing and a drug. NNadir Mar 2020 #8
One aspect that I've been trying to get up on - is the harumph Mar 2020 #13
Sure. In conversations with the general public, however we need to distinguish between... NNadir Mar 2020 #17
Thank you for sharing your experience here. KY_EnviroGuy Mar 2020 #34
Thank you. It's my pleasure. n/t. NNadir Mar 2020 #38
Does that mean that recovered patients who have wnylib Mar 2020 #19
What about protein synthesis? Been doing it at least since 2003 lagomorph777 Mar 2020 #18
I'm sorry, but it is naive to consider this lab scale result as having any practical... NNadir Mar 2020 #22
Thanks for the practical experience. As you say, I am naive. lagomorph777 Mar 2020 #23
It is perfectly fine to be naive. The problem, as we are seeing with the orange asshole, is... NNadir Mar 2020 #25
I hope I didn't seem to be claiming expertise. Just a moment of Googling. lagomorph777 Mar 2020 #28
You're fine. Even in a crisis, it's a good day any day you learn something new. NNadir Mar 2020 #29
This is good news Botany Mar 2020 #10
Great news! Just keep drumpfs' mitts off of it or none of us would be able to afford it. lark Mar 2020 #12
Crossed my mind that thus is the reason wnylib Mar 2020 #20
The malaria drug is cheap and generic Nonhlanhla Mar 2020 #24
There is no evidence whatsoever that it even really works. NNadir Mar 2020 #26
I know Nonhlanhla Mar 2020 #32
You did not suggest otherwise. The sad point is that because Trump googled, or had... NNadir Mar 2020 #35
Yes, and people in Nigeria also died from it Nonhlanhla Mar 2020 #36
You're being overly generous in stating that he halfway understands it. He's a completely... NNadir Mar 2020 #37
I'm aware of how his eagerness wnylib Mar 2020 #43
I suspect Remdesivir might turn out to be better Nonhlanhla Mar 2020 #45
Ah, another veteran of numerous bouts of wnylib Mar 2020 #46
Stay safe out there Nonhlanhla Mar 2020 #47
Well, I haven't left yet to pick up wnylib Mar 2020 #48
Sounds like you have the best plan Nonhlanhla Mar 2020 #49
I needed the long term Prednisone wnylib Mar 2020 #50
I took Prednisone for spine inflammation I_UndergroundPanther Mar 2020 #52
You nailed it. lark Mar 2020 #31
SCIENCE!!! :) Great news! nt Javaman Mar 2020 #14
No thanks to Trump. marble falls Mar 2020 #16
Sounds hopeful. I just hope no Cuban doctors are involved in the research Norbert Mar 2020 #21
"71 therapeutics in development, and 47 vaccines in development" Hortensis Mar 2020 #27
Science, for the WIN! Trailrider1951 Mar 2020 #30
Excellent news! HarlanPepper Mar 2020 #33
Whahoo! I_UndergroundPanther Mar 2020 #51
Fantastic- I hope it can be used as preventative as well until we get a vaccine nt Meowmee Mar 2020 #53
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