In one poll, Scottish independence had more support in England than Scotland:
Britain wants UK break up, poll shows
By Patrick Hennessy and Melissa Kite, Sunday Telegraph
Last Updated: 1:29am GMT 27/11/2006
A clear majority of people in both England and Scotland are in favour of full independence for Scotland, an ICM opinion poll for The Sunday Telegraph has found. Independence is backed by 52 per cent of Scots while an astonishing 59 per cent of English voters want Scotland to go it alone.
There is also further evidence of rising English nationalism with support for the establishment of an English parliament hitting an historic high of 68 per cent amongst English voters. Almost half – 48 per cent – also want complete independence for England, divorcing itself from Wales and Northern Ireland as well. Scottish voters also back an English breakaway with 58 per cent supporting an English parliament with similar powers to the Scottish one.
...
The ICM poll told a very different story, however, with 60 per cent of English voters complaining that higher levels of public spending per head of the population in Scotland were "unjustified", compared to 28 per cent claiming they were justified. Even among Scots, 36 per cent said the system was unfair, with only 51 per cent supporting it.
Voters also had serious concerns about the so-called West Lothian Question, the ability of Scottish MPs at Westminster to vote on solely English matters while many purely Scottish issues are decided in Edinburgh. Sixty-two per cent of English voters want Scottish MPs stripped of this right and even 46 per cent of Scots agreed. The poll showed that the English are more likely to think of themselves as British than the Scots are. Only 16 per cent of English people said they were "English, not British", compared to 26 per cent of Scots who said they were "Scottish, not British."
http://www.telegraph.co.uk/news/main.jhtml?xml=/news/2006/11/26/nunion26.xmlWhether the British government would be happy is a different matter. The nuclear submarines that New Labour and the Conservatives are both so keen to hang on to would need a new base in England (I'd have thought that would be fairly easy, but I don't know for sure); there could be other defence considerations (that might be solved with an agreement about military access to air space and territorial waters). North Sea oil would once have been a big problem - Westminster wouldn't want to see control of that go - but with the production winding down, it might not be too controversial. The excess government spending in Scotland is roughly paid for by the taxes from the oil, anyway.