Reply #1: my BIL is fighting this

[mopinko]

i can't be a lot of help, as i don't talk to my sister all that often. however, he has been battling it for several years.
he took these drugs as part of a drug trial. the biggest problem he had was a personality change. (or perhaps it is more accurate to say- an inflammation of his worse tendencies. i think the guy is an a-hole.) just my uneducated suspicion, seeing him when he was on that, the dark circles under his eyes, and the exhausted look on his face, i would guess it was disrupting his sleep. to a lot of docs, when you say sleep, they hear something like- voodoo. he did take welbutrin for this, but it only helped a little.
iirc, on the first go round, he did get down to a zero viral load, but that did not last. he has had at least 4 rounds. last i heard, he was looking at another round, but my sister was a little sick of it all.
so far, tho, it has kept his liver from deteriorating. he has managed to work, and function. (although he works from home/on his own schedule.)

to help him, i will say- sleep. why on earth docs look at you like you are just rationalizing your pathetic life when you start talking about sleep, i do not know. but make sure that this issue is taken seriously. (i could write a book...) if he needs some ambien or something, make sure he gets it.

some people seem to carry this virus for a long time without a lot of ill effects. some don't. modern medicine offers a lot of promise. but at this point i think there is still a lot of trial and error.
add chicken soup and sleep to whatever the docs say is my not very educated opinion.

best of luck to the both of you. keep us posted.