Reply #10: Silverlight will be a problem.

[Occulus]

Although Moonlight (IIRC the name) "works", you will no be able to use Netflix. Netflix will only work with the genuine Silverlight Windows installer (for encryption/security reasons) and Silverlight will not run via WINE.

Photoshop may run in WINE depending on the version.

I would try Ubuntu (I installed 11.04 just last night), but be aware that if you are forced into using a nonstandard desktop resolution, you may have trouble with X giving you a proper modeline to support your resolution. Since you're using an ATI card, this may not be an issue; my experience is solely with NVidia (largely due to ATI's historically abysmal linux support; this may have changed in the four or five years since I've had an ATI card).