Brain drug target discovery in MS (BBC)

[eppur_se_muova]

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Comparison of 2,538 proteins from MS patients with those from healthy brains showed damage in two proteins not before linked to the disease.
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Study leader Professor Lawrence Steinman said this was the first large-scale study to search for defective proteins in MS lesions in the brain.

They found a few proteins peculiar to MS brain lesions.

But two in particular - tissue factor and protein C inhibitor - showed signs of damage during the chronic active stage of the disease.

These normally participate in the control of blood clotting and in anti-inflammatory pathways. The researchers guessed that the damaged proteins might be helping the progression of MS and, by using inhibitors of the proteins found they could successfully ameliorate the disease in mice.
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more: http://news.bbc.co.uk/2/hi/health/7247420.stm

As always -- these are early results. Further studies needed.