Reply #49: There is at least one major difference.

[The Doctor.]

The printed picture, although ludicrous, cannot deliberately communicate it's own paradoxical intent the way that a live person can add inflection and expression to cue the audience to his intentions.

A picture that gives a negative impression, especially one based on many deep, however unfounded, fears, is lent to open, and potentially serious interpretation.

As an animated personality, Colbert can give cues to his audience. On top of that, he's already established the context of his message.

So yes, the difference is rather significant.