Study Provides More Evidence of Autism Immune Component
Evidence increasingly supports the notion of an autoimmune version of autism, and a new study involving specific autoantibodies that are directed at fetal brain tissue and that are found in a modest proportion of mothers with an autistic child, bolsters this theory.
In an earlier study, researchers at the Medical Investigation of Neurodevelopmental Disorders (MIND) Institute at the University of California, Davis, demonstrated that 12% of women with an autistic child had "unusual" antibodies not present in mothers of typically developing children or in mothers of children with other intellectual developmental disorders. Since this raised the hypothesis that the antibodies, which were immunoglobulin G and thus cross the placenta, might be interacting with the fetal brain, leading to disregulation of development (and ultimately to autism), the researchers expanded their study by testing the effects of the antibodies in pregnant Rhesus monkeys.
They found that the offspring of monkeys injected with the IgG showed distinctive autistic characteristics, David G. Amaral, Ph.D., research director at the MIND Institute, reported at the annual meeting of the American College of Neuropsychopharmacology.
Specifically, pregnant monkeys were injected over a 6-week period with either purified autoantibodies to fetal brain proteins from the blood of the mothers of children with autism, or with autoantibodies from mothers with typically developing children. The offspring of the monkeys injected with autoantibodies from mothers with an autistic child – but not those injected with samples from mothers of typically developing children, demonstrated social impairment and stereotypic behaviors across several behavioral testing paradigms, Dr. Amaral said during a press briefing held in conjunction with the meeting.
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