Anti Inflammatory Phytochemicals and Cox-2, Cancer Prevention

[HysteryDiagnosis]

Note I said PREVENTION, not treatment. All you self proclaimed Quackwatchers... PLEASE SEE THE LAST WORD. This **** is old btw.

http://www.sciencedirect.com/science/article/pii/S002751070100183X
The Inflammatory Factor Underlying Most Cancers

Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-κB activation

Young-Joon Surha, Corresponding Author Contact Information, E-mail The Corresponding Author, Kyung-Soo Chuna, Hyun-Ho Chaa, Seong Su Hana, Young-Sam Keuma, Kwang-Kyun Parkb, Sang Sup Leea
Purchase
a College of Pharmacy, Seoul National University, Shinlim-dong, Kwanak-ku, Seoul 151-742, South Korea
b Yonsei University College of Dentistry, Seoul 120-752, South Korea

Received 31 October 2000; revised 2 February 2001; Accepted 17 February 2001. Available online 9 August 2001.
Abstract

A wide array of phenolic substances, particularly those present in edible and medicinal plants, have been reported to possess substantial anticarcinogenic and antimutagenic activities. The majority of naturally occurring phenolics retain antioxidative and anti-inflammatory properties which appear to contribute to their chemopreventive or chemoprotective activity. Cyclooxygenase-2 (COX-2) inducible and nitric oxide synthase (iNOS) are important enzymes that mediate inflammatory processes. Improper up-regulation of COX-2 and/or iNOS has been associated with pathophysiology of certain types of human cancers as well as inflammatory disorders.

Since inflammation is closely linked to tumor promotion, substances with potent anti-inflammatory activities are anticipated to exert chemopreventive effects on carcinogenesis, particularly in the promotion stage. Examples are curcumin, a yellow pigment of turmeric (Curcuma longa L., Zingiberaceae), the green tea polyphenol epigallocatechin gallate (EGCG), and resveratrol from grapes (Vitis vinifera, Vitaceae) that strongly suppress tumor promotion.

Recent studies have demonstrated that eukaryotic transcription factor nuclear factor-kappa B (NF-κB) is involved in regulation of COX-2 and iNOS expression. Several chemopreventive phytochemicals have been shown to inhibit COX-2 and iNOS expression by blocking improper NF-κB activation. Multiple lines of compelling evidence indicate that extracellular-regulated protein kinase and p38 mitogen-activated protein kinase are key elements of the intracellular signaling cascades responsible for NF-κB activation in response to a wide array of external stimuli.

Curcumin, EGCG and resveratrol have been shown to suppress activation of NF-κB. One of the plausible mechanisms underlying inhibition of NF-κB activation by aforementioned phytochemicals involves repression of degradation of the inhibitory unit IκBα, which hampers subsequent nuclear translocation of the functionally active subunit of NF-κB.

Keywords: Chemopreventive phytochemicals; Cyclooxygenase; Inducible nitric oxide synthase; NF-κB; Curcumin; Epigallocatechin gallate; Resveratrol

[MineralMan]

1. Where's the link?

If we can't go look at it, it's useless. Where did you find this?

OK. Never mind. I Googled the title. It's from www.lef.org. Now I see why you left out the link. A guy can buy all the cool stuff in that article there, huh? Conflict of interest?

[HysteryDiagnosis]

3. Mmmm forgot the link... so that makes all the information

questionable or better yet false. You are a card.

http://www.sciencedirect.com/science/article/pii/S002751070100183X

[MineralMan]

5. That's a valid link, but not to the article you quoted.

There's the problem.

When I searched the quoted title in your post, the first six links were to LEF.org. Not particularly encouraging, I think.

You can find information anywhere. Why use stuff from that site which has a constant conflict of interest?

[HysteryDiagnosis]

6. You can email sciencedirect and tell them to have LEF stop quoting

their questionable research.

[MineralMan]

8. Never mind.

[HysteryDiagnosis]

9. I don't see the difference between the links or the research. I must be

tired.

[a simple pattern]

4. I found it here too:

http://www.ncbi.nlm.nih.gov/pubmed/11506818

[HysteryDiagnosis]

7. You can't trust them, they work for the government. They'll tell you

anything to sell you something. Kidding of course, thanks for the find.

[SidDithers]

12. "The Inflammatory Factor Underlying Most Cancers" doesn't appear there either...nt

Sid

[Duer 157099]

2. I believe that inflammation will ultimately be shown to be the biggest risk factor

for a huge number of diseases. It seems to be the underlying common factor in almost every (non-genetic) disease I know about.

[MineralMan]

10. Has any further research been done on this since 2001?

This is sort of an old article, as science articles go...

[SidDithers]

11. "The Inflammatory Factor Underlying Most Cancers" isn't at the link provided..

it only shows up at lef.org

Why did you attach an LEF headline to the abstract of a research paper published in Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis?

You've made it appear that the headline "The Inflammatory Factor Underlying Most Cancers" is somehow part of the research paper, especially by putting the headline between the sciencedirect link and the paper's abstract.

Very misleading.

Sid

[Celebration]

13. not sure why that makes any difference??

a headline?

[SidDithers]

14. Should we just stick anything we want into the text of a research paper?...

Why is that lef.org headline in there at all?

Sid