Reply #25: There are people who take between 10 and 20 grams per day,

[HysteryDiagnosis]

"just to be safe". If a rabbit, (that still retains the enzymatic ability to make ascorbic acid) feels the need to make 14 grams of ascorbic acid per day, and he only weighs between 6 to 10 pounds.... then going by human body weight.... what "REALLY" is an optimal amount for us????


This will give you an idea as to why I queried about your immune system status.... your blood counts may be good... but this is referring to your intestinal environment....

1: J Clin Pathol. 2004 Sep;57(9):973-9. Related Articles, Links


Colonic IgA producing cells and macrophages are reduced in recurrent and non-recurrent Clostridium difficile associated diarrhoea.

Johal SS, Lambert CP, Hammond J, James PD, Borriello SP, Mahida YR.

Division of Gastroenterology, University Hospital, Nottingham NG7 2UH, UK.

BACKGROUND: In Clostridium difficile associated diarrhoea (CDAD), histological changes in the colonic mucosa range from minimal inflammation to pseudomembranous colitis (PMC). The disease also recurs in a considerable proportion of patients. AIM: To investigate mucosal immune system cells in colonic biopsies of patients with CDAD. METHODS: Colonic biopsies were obtained from 12 control patients with diarrhoea, six patients with CDAD and minimal inflammation, and 10 patients with CDAD with pseudomembranous colitis (samples obtained from areas with and without inflammatory exudate). Immunohistochemical studies were performed using antibodies to T cells (CD3), macrophages (CD68), B/plasma cells (CD79alpha), and to IgA, IgM, and IgG. Labelled cells in lamina propria were quantified.

RESULTS: In contrast to T cells, there were significant reductions in B/plasma cell and macrophage counts in all biopsies from patients with CDAD compared with controls (p<0.001). Studies using anti-immunoglobulin antibodies showed significant reductions in IgA producing cells in CDAD biopsies (p<0.05), with the greatest reduction in samples from patients with PMC. In contrast, there was a significant increase (p<0.05) in IgG producing cells in CDAD biopsies. Only patients with PMC relapsed. In these patients, B/plasma cell and IgA producing cell counts (in biopsies with and without inflammatory exudates) were significantly lower (p<0.01) in mucosal samples from those who subsequently relapsed (five) than those who did not.

CONCLUSIONS: A selective reduction in mucosal IgA producing cells and macrophages is associated with colonic disease in C difficile infected patients. Severe reduction in colonic IgA producing cells may predispose to recurrence of CDAD.

PMID: 15333661