There was an episode wherein young Sheldon was challenged by a philosophy teacher. I see that as the take off point for a new show, The "Alternative Sheldon"
Sheldon pursues philosophy, becomes a professor, an ethicist; for elder Sheldon, that is perfect because no one wants to talk ethics and philosophers are never invited to parties. However, because the answers to life's questions, as in physics, continue to elude, Sheldon becomes jaded.
The same big questions can be pursued, like "what the hell is consciousness anyway"? and "do we need Gods to be good?"
Some of the first show's tropes, characters, places could be used, like Sheldon renting a flat from Penny and Leonard.
Eastern and western philosophies might clash with a new, more alpha maharaj, the swami-acharya of the yoga center on the ground floor.
And of course the answers to the ancient questions of mind and matter will certainly be found, in next week's episode.
Old Sheldon, The Petulant Philosopher"
If any of you know those, who know how to run with idea, go for it.
But take care running because ideas, like scissors, can stab one.