One of the side affects of LSD is such tendencies, you b
There is some indication that LSD may trigger a dissociative fugue state in individuals who are taking certain classes of antidepressants such as lithium salts and tricyclics. In such a state, the user has an impulse to wander, and may not be aware of his or her actions, which can lead to physical injury. Anonymous anecdotal reports have attributed seizures and one death to the combination of LSD with lithium.
http://en.wikipedia.org/wiki/Lysergic_acid_diethylamide#Adverse_drug_interactions
http://www.erowid.org/chemicals/lsd/lsd_health3.shtml
2. Lithium or tricyclics (like Amitriptyline, Anafranil, Asendin, Aventyl, Elavil, Endep, Norfranil, Norpramin, Pamelor, Sinequan, Surmontil, Tipramine, Tofranil, Vivactil) are fairly consistently reported as being very bad in combination with LSD. People attempting this combination are unable to communicate with others, they go into "fugue states" where they end up in other places and don't know how they got there, and they are generally in a terrible place psychologically. Life-threatening seizures and at least one DEATH have been reported to be triggered by the combination of LSD and lithium.
http://www.erowid.org/chemicals/lsd/lsd_health3.shtml
May be some other drug, but such flights have occurred with just light amount of drugs.