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Response to dalton99a (Reply #53)

Sun Apr 25, 2021, 01:14 PM

70. Thanks for this. ❤ What the Immune System Does Between the First and Second Dose

From the article. . .
WHY MRNA VACCINES NEED TWO DOSES TO BEST WORK AND WHAT DELAYS MIGHT MEAN
Sub Header:
What the Immune System Does Between the First and Second Dose:


The biology through which the mRNA vaccines induce their protection from COVID-19 is fundamentally different from that with other vaccines.

Pfizer and Moderna vaccines use messenger RNA that encodes the spike glycoprotein. Upon injection of the vaccine, the mRNA enters into immune cells called dendritic cells. The dendritic cells use the instructions written in the mRNA to synthesize the hallmark spike glycoprotein, which characterizes the SARS-CoV-2 virus that causes COVID-19. These immune cells then show the spike glycoprotein to B-cells, which then make anti-spike antibodies.

Dendritic cells recognize viruses and present information about the spike protein to T-cells. T-cells provide information about the viral spike protein to B-cells, which are transformed to memory B-cells that store information about the virus. When this memory B-cell is activated with an infection or the second dose of the vaccine, this causes some of the B-cells to change into plasma B-cells that secrete protective antibodies that fight the virus.

The mRNA vaccines are uniquely capable of inducing a special kind of immune cell called a T-follicular helper cell to help B-cells produce antibodies. The T-cells do this through direct contact with the B-cells and by sending chemical signals that tell the B-cells to produce antibodies. It is this help in antibody production that makes these vaccines so effective.

More...

https://news.virginia.edu/content/why-mrna-vaccines-need-two-doses-best-work-and-what-delays-might-mean

I had my first Moderna. I was sick for four days with fatigue, nausea, muscle and join pain with a sore arm, shoulder. I'd do it again a hundred times if I could help my family, friends and neighbors fight getting Covid.


(I was also brought up in a family that believes it is rude to talk about one's medical issues in so called "polite company" but here we are...)

Thanks for sharing the article, dalton99a.


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