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Response to Laelth (Reply #1)

Mon Jun 29, 2020, 02:26 PM

26. The mutation appears to affect infectivity

or better put, the ability to bind to ACE-2 (the receptor protein) and allow entry into the host cell. As I recall from reading the original paper on this, the occurrence of severe illness and death seems to be unaffected. However, the density of virions (viral particles) was increased in those infected with the mutant strain. This would certainly allow for viruses containing this mutation to become dominant - faster to infect will allow those viruses to spread a bit faster. Evolution by selection for strains that reproduce faster. This will work really well when populations are growing exponentially and, therefore, when the population of those people who are infected are increasing rapidly - like at the beginning of the pandemic and now in some areas of the US.

Questions: what other mutations are becoming more prevalent in the populations in Florida, Texas, California, etc.? How will those mutations affect virulence?

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usaf-vet Jun 29 OP
Laelth Jun 29 #1
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