You might have figured this out (Reply #33)

In the discussion thread: Smokers 'four times less likely' to contract Covid-19, prompting nicotine patch trials on patients [View all]

Response to Bernardo de La Paz (Reply #2)

Thu Apr 23, 2020, 04:33 PM

Mike 03 (15,933 posts)

33. You might have figured this out

Nicotine is a nonselective agonist of the α7Ach receptor and is able to suppress the production of proinflammatory cytokines by mimicking the binding of acetylcholine. It has been demonstrated that nicotine can selectively reduce the inflammatory response in a number of infection scenarios, including Legionella pneumophila (54) and Chlamydia pneumoniae (55) infection; however, it is highly unlikely that nicotine will ever be used clinically due to its toxicity, addictive nature, and lack of specificity.

From Clin Vaccine Immunol. 2013 Mar; 20(3): 319–327.
doi: 10.1128/CVI.00636-12
PMCID: PMC3592351
PMID: 23283640
Targeting the “Cytokine Storm” for Therapeutic Benefit
Riccardo V. D'Elia,corresponding author Kate Harrison, Petra C. Oyston, Roman A. Lukaszewski, and Graeme C. Clark

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3592351/

There's also a paper about the use of nicotine to suppress cytokine production in Crohn's Disease:

In-vivo effect of nicotine on cytokine production by human non-adherent mononuclear cells. (result: Nicotine inhibits Interleukin 10)

https://www.ncbi.nlm.nih.gov/pubmed/8930570

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Replies to this discussion thread

86 replies	Author	Time	Post
Smokers 'four times less likely' to contract Covid-19, prompting nicotine patch trials on patients [View all]	Tactical Peek	Apr 2020	OP
Maybe there's less blood flow to the lungs.	LisaM	Apr 2020	#1
I was wondering that too, sort of.	Mike 03	Apr 2020	#7
And there's less blood going to the lungs to clot.	LisaM	Apr 2020	#11
Thinking outside the box is appreciated, at least by me.	Mike 03	Apr 2020	#16
Ha!	LisaM	Apr 2020	#19
In most cases already dealing with impared lungs with smokers.	mpcamb	Apr 2020	#60
my first thought was the tar, not the nicotine	yellowdogintexas	Apr 2020	#83
More likely that.....	capechacon	Apr 2020	#54
Yep I think lung tissue changes in smokers--mayby	live love laugh	Apr 2020	#82
Nicotine might have something to do with blood clotting or cytokine storm . . . nt	Bernardo de La Paz	Apr 2020	#2
You might have figured this out	Mike 03	Apr 2020	#33
An additional α7nAChR agonist, anti-inflammatory	Aimee in OKC	Apr 2020	#73
Cannabis ought to be able to do the same... wonder if it's being studied as well.	JudyM	Apr 2020	#51
Not necessarily. Nicotine is an alkaloid. Cannabis is not & has own specialized neurochemicals. .nt	Bernardo de La Paz	Apr 2020	#53
It's anti-inflammatory though, and has anticoagulant properties.	JudyM	Apr 2020	#56
Smoke	Faux pas	Apr 2020	#3
Sounds like Bayesian statistics biting scientists in the rear again	Loki Liesmith	Apr 2020	#4
Probably because....	SergeStorms	Apr 2020	#72
As An Ex-Smoker	RobinA	Apr 2020	#74
You don't think smokers....	SergeStorms	Apr 2020	#84
Did they also test baguette eaters and pate' lovers? Wine aficionados? Jerry Lewis fans?	BamaRefugee	Apr 2020	#5
I'm very skeptical of studies like this	IronLionZion	Apr 2020	#6
Maybe the smokers, knowing they were more at risk...	moriah	Apr 2020	#64
We knew there was some	Sgent	Apr 2020	#79
Ahead of his time	The Mouth	Apr 2020	#8
You beat me to it. n/t	customerserviceguy	Apr 2020	#30
All of this self-isolating	sdfernando	Apr 2020	#42
!	JudyM	Apr 2020	#50
Maybe lung cancer, but who's counting?	brush	Apr 2020	#9
I'll take it. For me, the report adds a positive to smoking as a "coping mechanism."	ancianita	Apr 2020	#10
+1 In grade school I had a crush on Alain Delon but didn't	appalachiablue	Apr 2020	#29
Hahaha... yes, anything helps!	ancianita	Apr 2020	#39
This is what I posted on another thread about this topic.	Mike 03	Apr 2020	#12
Thank you for this! Interesting stuff!	ancianita	Apr 2020	#40
Check out nicotine properties, anti viral, poss Alz treatment	appalachiablue	Apr 2020	#81
If this is true...	Marrah_Goodman	Apr 2020	#13
I have another good reason to vape right now	Leith	Apr 2020	#21
She freaked after all the BS erroneous media reports that failed to mention the real problem	Marrah_Goodman	Apr 2020	#26
They should also compare their findings with people who use nicotine but NOT by	Mike 03	Apr 2020	#14
Interesting text from the article...	Buckeye_Democrat	Apr 2020	#15
Thank you for catching this.	Mike 03	Apr 2020	#17
So, finally a problem we can solve with alcohol and cigarettes?	htuttle	Apr 2020	#18
But not at the same time, lest one combusts.	eggplant	Apr 2020	#41
add a little sugar and some caffeine..	stillcool	Apr 2020	#46
Kick	burrowowl	Apr 2020	#20
The prisoners are really going to be fighting over the cigarettes now I guess. :) nt	Sloumeau	Apr 2020	#22
Pinched lungs or a substance that inhibits the virus	bucolic_frolic	Apr 2020	#23
FWIW, I'm completely striking out finding ANY papers or articles	Mike 03	Apr 2020	#24
OK, we'll start to see TP again	Warpy	Apr 2020	#25
My husband used to smoke and now vapes.	EllieBC	Apr 2020	#27
This message was self-deleted by its author	customerserviceguy	Apr 2020	#28
Four people I know would have loved to hear this!	StarryNite	Apr 2020	#31
Is it the smoke or the nicotine...	imavoter	Apr 2020	#32
Smokers of...what?	B Stieg	Apr 2020	#34
This sounds like really good news	Chainfire	Apr 2020	#35
Everything about this is wrong. Now I am FB my people, texting my sons.	LizBeth	Apr 2020	#36
My Father	RobinA	Apr 2020	#75
Maybe it's because smokers are obnoxious and repel others, thus achieving social distancing.	Towlie	Apr 2020	#37
Hey! LOTS of Democrats like me smoke!	ancianita	Apr 2020	#45
I find just the opposite.	former9thward	Apr 2020	#59
I'm An Ex-Smoker	RobinA	Apr 2020	#76
I quit smoking 10 years ago	Skittles	Apr 2020	#85
Yup, Smokers are a lot more personable I've found.	tavernier	Apr 2020	#78
Long long ago when I was a waitress I preferred the smoking section	EllieBC	Apr 2020	#80
That's my hypothesis...	Hugin	Apr 2020	#67
Are smokers younger? Lower BMI? Less likely to have other health issues?	Tiger8	Apr 2020	#38
This was the plot of an old short story	Shrek	Apr 2020	#43
Hey MAGAts! This just in!	HuskyOffset	Apr 2020	#44
In the words of their false Messiah-- "What have you got to lose?" /nt	spudspud	Apr 2020	#48
Oh, I get it now. A little reverse psychology, eh?	Tiger8	Apr 2020	#49
This study brought to you by your friendly, neighborhood Big Tobacco firm. /nt	spudspud	Apr 2020	#47
If smoking prevented Coronavirus,	Mr.Bill	Apr 2020	#52
and...............................	trixie2	Apr 2020	#55
it doesn't make me want to go outside,	barbtries	Apr 2020	#57
Looks like I picked the wrong week to quit smoking!	klook	Apr 2020	#58
Try googling "nicotine kills viruses and bacteria"	Maeve	Apr 2020	#61
This study brought to you by Altria	JDC	Apr 2020	#62
Study sponsored by Joe Camel	amuse bouche	Apr 2020	#63
It's because nobody will come within 10ft of a smoker...	Hugin	Apr 2020	#65
Hmmm. When this first broke out in China,	PoindexterOglethorpe	Apr 2020	#66
Let's say it turns out to be true...	Hugin	Apr 2020	#69
I don't believe	Rebl2	Apr 2020	#71
No one gets within 6 ft of them	Soxfan58	Apr 2020	#68
Call your broker in the morning and	safeinOhio	Apr 2020	#70
I thought this was a respiratory illness.	Initech	Apr 2020	#77
One of the reasons given for why Italy was hit so hard was because smoking was common	JI7	Apr 2020	#86

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