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Response to malaise (Original post)

Mon May 17, 2021, 10:07 PM

8. The majority of the planned shipments will be of the AstraZeneca vaccine, which is a massive fail

against the B.1.351 South African variant running riot in many places. It only has a 10.4% efficacy rate v B.1.351.

https://www.npr.org/2021/05/17/997575473/u-s-to-ship-20-million-additional-covid-vaccine-doses-overseas




Efficacy of the ChAdOx1 nCoV-19 Covid-19 Vaccine against the B.1.351 Variant



https://www.nejm.org/doi/full/10.1056/nejmoa2102214

RESULTS

Between June 24 and November 9, 2020, we enrolled 2026 HIV-negative adults (median age, 30 years); 1010 and 1011 participants received at least one dose of placebo or vaccine, respectively. Both the pseudovirus and the live-virus neutralization assays showed greater resistance to the B.1.351 variant in serum samples obtained from vaccine recipients than in samples from placebo recipients. In the primary end-point analysis, mild-to-moderate Covid-19 developed in 23 of 717 placebo recipients (3.2%) and in 19 of 750 vaccine recipients (2.5%), for an efficacy of 21.9% (95% confidence interval [CI], −49.9 to 59.8). Among the 42 participants with Covid-19, 39 cases (95.1% of 41 with sequencing data) were caused by the B.1.351 variant; vaccine efficacy against this variant, analyzed as a secondary end point, was 10.4% (95% CI, −76.8 to 54.8). The incidence of serious adverse events was balanced between the vaccine and placebo groups.

CONCLUSIONS

A two-dose regimen of the ChAdOx1 nCoV-19 vaccine did not show protection against mild-to-moderate Covid-19 due to the B.1.351 variant. (Funded by the Bill and Melinda Gates Foundation and others; ClinicalTrials.gov number, NCT04444674.


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malaise May 17 OP
alfredo May 17 #1
malaise May 17 #2
alfredo May 17 #3
BootinUp May 17 #4
alfredo May 17 #10
NH Ethylene May 17 #5
mgardener May 17 #7
orleans May 17 #9
spanone May 17 #6
LineNew Reply The majority of the planned shipments will be of the AstraZeneca vaccine, which is a massive fail
Celerity May 17 #8
NJCher May 17 #11
Joe Nation May 17 #12
malaise May 18 #14
Joe Nation May 18 #15
malaise May 18 #16
BobTheSubgenius May 17 #13
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