Although Donald Trump never pooh-poohed the coronavirus vaccine, he also didn't get a shot on television, as did Mike Pence. To some of his most faithful supporters, that was a sign that it might be dangerous. It's true that he had COVID-19, but Anthony Fauci has recommended getting the vaccine anyway, even if you had the disease.
The good news is that now that Trump has largely gone radio silent and de facto stopped being president (except for furiously exercising the pardon power), people who were against getting the vaccine are having a change of heart. In some cases, that is due to high-profile people getting the vaccine in public (Fauci, Mike Pence, Joe Biden, etc.), and in some cases the "opposition" to the vaccine ("I don't trust big government/big pharma"

was abstract and didn't matter since it wasn't available anyway. But now that it is starting to be delivered, people have a very specific choice to make. And with 200,000 people a day getting COVID-19 and well over 3,000 dying from it every day, people who opposed the vaccine "in principle" are now starting to put their own health above abstract principles. Also a factor is that science is "in" again, with Biden repeatedly saying that he will follow the advice of doctors and scientists in areas of their competence. This undoubtedly will influence some people.
Pollsters have noted the change in public opinion. Polls from Gallup, the Kaiser Family Foundation, and the Pew Research Center have all shown that the portion of the population planning to get vaccinated has grown from 50% in the summer to 60%, 65%, or even 73% in one recent poll. Once Biden takes over and starts urging people to protect their health and get the vaccine, many more will probably drop their objections. Also, Biden will undoubtedly unmuzzle Anthony Fauci, who is widely respected on matters of health, and have him talk to the media constantly. In addition, Biden's choice for surgeon general, Vivek Murthy, who was surgeon general in the Obama administration, will also play a role. Earlier this month, Murthy said: "I am grateful for this opportunity to help end the pandemic." With virtually everyone in the federal government urging people to get vaccinated as soon as that is possible, it is entirely possible that 70% or more of the population will have been vaccinated by the summer. That may be close to enough to achieve a reasonable herd immunity.
There is also some sizable contingent of Americans who might not get the vaccine, if left to their own devices, but who will be compelled to do so by their employers. Many universities, for example, already mandate that faculty and staff get flu shots each year, and COVID-19 shots will surely be added to the list, if they haven't been already. Undoubtedly, many secondary and primary schools will adopt similar measures. Similarly, it is probable that businesses that are public-facing will also require employees to get vaccinated. Can the management at, say, Antonio's Pizzeria and Italian Restaurant really run the risk that one of their wait staff becomes infected and passes the disease on to a bunch of staffers and employees? It is plausible that someone required to get a COVID-19 vaccination in order to keep their jobs could sue, but anti-vaxxers are not a protected class, and besides, they'd be out of a job for two years while the suit was resolved. Probably easier to just bow to reality. Court decisions make it clear that private companies can make reasonable demands on their employees to safeguard other employees and customers. So no, you don't have some "constitutional right" to tell Antonio that you aren't going to get vaccinated and that is his problem. It is your problem trying to explain to your next potential employer why you and Antonio parted ways.
more
https://www.electoral-vote.com/evp2020/Pres/Maps/Dec28.html#item-8