HomeLatest ThreadsGreatest ThreadsForums & GroupsMy SubscriptionsMy Posts
DU Home » Latest Threads » Forums & Groups » Topics » Science » Science (Group) » Magic mushroom compound m...

Sat Jan 6, 2018, 09:18 AM

Magic mushroom compound might treat depression by reviving emotional responsiveness in the brain

From http://www.psypost.org/2018/01/magic-mushroom

Magic mushroom compound might treat depression by reviving emotional responsiveness in the brain
ERIC W. DOLAN January 5, 2018

New research suggests that psilocybin-assisted therapy helps alleviate treatment-resistant depression by reviving emotional responsiveness in the brain.

Psilocybin is the primary mind-altering substance in psychedelic “magic” mushrooms. The drug can profoundly alter the way a person experiences the world by producing changes in mood, sensory perception, time perception, and sense of self.

...



From https://www.sciencedirect.com/science/article/pii/S0028390817306391

Highlights
• Psilocybin with psychological support was used successfully to treat depression.
• Amygdala responses to fearful faces were increased one day after psilocybin session.
• Increased amygdala responses predicted positive clinical outcomes.
• Psilocybin assisted therapy treats depression by reviving emotional responsiveness.

Abstract
Recent evidence indicates that psilocybin with psychological support may be effective for treating depression. Some studies have found that patients with depression show heightened amygdala responses to fearful faces and there is reliable evidence that treatment with SSRIs attenuates amygdala responses (Ma, 2015). We hypothesised that amygdala responses to emotional faces would be altered post-treatment with psilocybin. In this open-label study, 20 individuals diagnosed with moderate to severe, treatment-resistant depression, underwent two separate dosing sessions with psilocybin. Psychological support was provided before, during and after these sessions and 19 completed fMRI scans one week prior to the first session and one day after the second and last. Neutral, fearful and happy faces were presented in the scanner and analyses focused on the amygdala. Group results revealed rapid and enduring improvements in depressive symptoms post psilocybin. Increased responses to fearful and happy faces were observed in the right amygdala post-treatment, and right amygdala increases to fearful versus neutral faces were predictive of clinical improvements at 1-week. Psilocybin with psychological support was associated with increased amygdala responses to emotional stimuli, an opposite effect to previous findings with SSRIs. This suggests fundamental differences in these treatments’ therapeutic actions, with SSRIs mitigating negative emotions and psilocybin allowing patients to confront and work through them. Based on the present results, we propose that psilocybin with psychological support is a treatment approach that potentially revives emotional responsiveness in depression, enabling patients to reconnect with their emotions.

...



More at links.

5 replies, 647 views

Reply to this thread

Back to top Alert abuse

Always highlight: 10 newest replies | Replies posted after I mark a forum
Replies to this discussion thread
Arrow 5 replies Author Time Post
Reply Magic mushroom compound might treat depression by reviving emotional responsiveness in the brain (Original post)
sl8 Jan 2018 OP
lastlib Jan 2018 #1
sl8 Jan 2018 #3
gvstn Jan 2018 #2
sl8 Jan 2018 #4
gvstn Jan 2018 #5

Response to sl8 (Original post)

Sun Jan 7, 2018, 03:35 PM

1. I think this post is begging for this:



When the men on the chessboard
Get up and tell you where to go
And you've just had some kind of mushroom
And your mind is moving low.
Go ask Alice, I think she'll know.


. . . .

Reply to this post

Back to top Alert abuse Link here Permalink


Response to lastlib (Reply #1)

Mon Jan 8, 2018, 04:42 PM

3. They could account for that generation's legendary emotional well-being. :). n/t

Reply to this post

Back to top Alert abuse Link here Permalink


Response to sl8 (Original post)

Mon Jan 8, 2018, 04:06 PM

2. This has been documented for a couple of years.

I've read so many articles. Why don't they get this on the market already?

I also want to know if the treatment they are using (isolating the effective chemical) eliminates the "trip" part of taking mushrooms or if that would be an effect of the pharmaceutical version. This never seems to be mentioned.

Reply to this post

Back to top Alert abuse Link here Permalink


Response to gvstn (Reply #2)

Mon Jan 8, 2018, 04:45 PM

4. The magazine article says that the patients undergo a psychedelic experience

...
It is important to emphasize that psilocybin-assisted therapy is a model in which the patient is undergoing a deep psychological process in one or few psychedelic sessions, in which he might have an intense cathartic experience, or peak experience,” Roseman explained.

Patients receive a dose of psilocybin in a controlled setting while professionals are on hand to provide them with psychological support. The patients also typically receive counseling before and after each session, to help them prepare for and integrate their psychedelic experience.
...


Also, the study references the "high" that the patients experience.

Reply to this post

Back to top Alert abuse Link here Permalink


Response to sl8 (Reply #4)

Mon Jan 8, 2018, 05:03 PM

5. Thanks, I do remember reading that now.

I must say that I did mushrooms when I was much younger and I noticed a good effect on my depressed personality. Just felt more in tune with the world and people around me. I can't say how long the effect lasted but I would definitely say the 6 mos. range stated in the article is pushing it.

I really would like to try them again and could probably find someone to get them. I just would rather not experience the "trip" at my age. Oh well. I wait to see if they offer any trial sessions in my area.

Reply to this post

Back to top Alert abuse Link here Permalink

Reply to this thread