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Thu Jan 24, 2013, 04:11 PM

Interesting info regarding DIM and I3C

Good article! As always, before taking nutritional supplements, discuss with your doctor first for possible drug interactions.


"Anyone advocating the benefits of I3C over DIM is ignoring the published scientific facts. A careful review of the research reveals serious questions concerning the safety of I3C. For example, the National Institute of Health (NIH) in its Chemoprevention Branch Report on I3C safety issues says: "Subchronic, preclinical toxicology studies in dogs have identified significant toxicities associated with oral administration of I3C... The possible enhancing effects of I3C on chemical carcinogenesis and toxicity should be investigated, especially in light of the wide variety of enzymes induced... The fact that the I3C condensation product ICZ has both antiestrogenic and estrogenic activities also may have safety implications... Additional genetic toxicity testing may be required." (1)"

First, there are many published studies on DIM. There are over 40 studies in the National Library of Medicine Database which involve DIM. In 2001 alone, seven studies were published. In addition, well-controlled, independently-performed human studies have been completed and are awaiting publication. These include use of DIM showing statistically significant benefits for recurrent breast pain and improvement of cervical dysplasia.

Second, ICZ (indolocarbazole) is not a safe derivative of I3C. ICZ activates the dioxin receptor just like dioxin. ICZ does not block it. It is DIM that blocks this receptor (2). This is one of the key benefits of using a stable DIM supplement.

Third, more is not necessarily better. Having a family of reactive products being generated does not provide broader cancer protection if many of these products also have unwanted side effects. Side effects are tolerable in certain cancer treatment drugs for established cancer but not in nutritional substances meant to prevent cancer in healthy individuals."

More at link:


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Reply Interesting info regarding DIM and I3C (Original post)
BuddhaGirl Jan 2013 OP
2on2u Jan 2013 #1
Celebration Jan 2013 #2
BuddhaGirl Jan 2013 #3

Response to BuddhaGirl (Original post)

Thu Jan 24, 2013, 04:37 PM

1. Kick, the cons outweight the pros in each and every case imho, on edit to add some very


important stuff.

Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates) interacts with DIINDOLYLMETHANE

Some medications are changed and broken down by the liver.
Diindolylmethane might increase how quickly the liver breaks down some medications. Taking diindolylmethane along with some medications that are changed by the liver can decrease the effectiveness of some medications. Before taking diindolylmethane talk to your healthcare provider if you take any medications that are changed by the liver.
Some of these medications that are changed by the liver include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), theophylline, zileuton (Zyflo), zolmitriptan (Zomig), and others.

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Response to BuddhaGirl (Original post)

Fri Jan 25, 2013, 12:41 AM

2. Broccoli!!

Democrats should really love broccoli because wasn't it Bush I who hated it? He tried to make a joke about it and made a complete ass out of himself. Furthermore, he didn't even use being on drugs as an excuse.

I do not like broccoli. And I haven't liked it since I was a little kid and my mother made me eat it. And I'm President of the United States and I'm not going to eat any more broccoli.
George H. W. Bush

Read more at http://www.brainyquote.com/quotes/quotes/g/georgehw110377.html#H4SWP4u0EGTbAi1q.99

Before eating broccoli (or any vegetable or fruit or grain or meat for that matter) be sure to clear it with your doctor. If you don't have health insurance just suck it up and pay. YOU DO NOT NEED TO GET PERMISSION FROM BUSH, and be THANKFUL for that because you likely will not get it.

If your doctor won't let you eat broccoli because of drug interactions, or because he is in sympathy with Bush I, then just take a cool photo of it, get it printed as a poster and hang it in your kitchen! And DROOL over it. And, be glad that a Republican is not in the White House.

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Response to Celebration (Reply #2)

Fri Jan 25, 2013, 03:35 PM

3. those damned narrow-minded broccoli-hating republicans!

I mean, what they really want is that we only get broccoli from a big corporation who patents it and sell it for an exorbitant price!!

Can't eat anything natural...oh noes, can't have that!

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