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Thu Dec 27, 2012, 08:07 PM


Probiotics, Obesity, Diabetes Mellitus

The purpose of this post is to discuss health and health related issues. There is no advertising or selling of specific health products herein. No services or treatments are recommended or advised.

For information on medical advice for specific health concerns please see your healthcare provider.... he or she may or may not be familiar with the following information but that is just the way it is.


Gastroenterol Clin North Am. 2012 Dec;41(4):843-54. doi: 10.1016/j.gtc.2012.08.009.
Probiotics, prebiotics, energy balance, and obesity: mechanistic insights and therapeutic implications.
Molinaro F, Paschetta E, Cassader M, Gambino R, Musso G.

Department of Medical Sciences, Corso AM Dogliotti 14 10124, University of Turin, Italy.

Obesity-related disorders derive from a combination of genetic susceptibility and environmental factors. Recent evidence supports the role of gut microbiota in the pathogenesis of obesity, type 2 diabetes mellitus, and insulin resistance by increasing energy harvest from diet and by inducing chronic, low-grade inflammation. Several studies describe characteristic differences between composition and activity of gut microbiota of lean individuals and those with obesity. Despite this evidence, some pathophysiological mechanisms remain to be clarified. This article discusses mechanisms connecting gut microbiota to obesity and fat storage and the potential therapeutic role of probiotics and prebiotics.

Copyright 2012 Elsevier Inc. All rights reserved.

Gut Pathog. 2012 Nov 26;4(1):15. [Epub ahead of print]
Probiotics for human health -new innovations and emerging trends.
Grover S, Rashmi HM, Srivastava AK, Batish VK.

ABSTRACT: The role of the gut microbiome in human health and disease with a particular emphasis on therapeutic use of probiotics under specific medical conditions was mainly highlighted in 1st Annual conference of Probiotic Association of India (PAi) and International Symposium on "Probiotics for Human Health - New Innovations and Emerging Trends" held on 27th-28th August, 2012 at New Delhi, India.

There is increasing recognition of the fact that dysbiosis or alteration of this gut microbiome may be implicated in gastro-intestinal disorders including diarrheal diseases, ulcerative colitis, inflammatory bowel diseases, life style diseases viz. Diabetes Mellitus-2 and obesity etc. This report summarizes the proceedings of the conference and the symposium comprehensively. Although, research on probiotics has been continuing for the past few decades, the subject has been currently the major focus of attention across the world due to recent advances and new developments in genomics, transcriptomics, proteomics, metabolomics and emergence of new generation of high through put sequencing technologies that have immensely helped in understanding the probiotic functionality and mode of action from nutritional and health perspectives.

There is now sufficient evidence backed up with good quality scientific clinical data to suggest that probiotic interventions could indeed be effective in various types of diarrheal diseases, other chronic gastrointestinal inflammatory disorders like pouchitis, necrotizing entero-colitis, allergic responses and lactose intolerance etc. This report makes a modest attempt to give all the stake holders involved in development of probiotic based functional/health foods an overview of the current status of probiotics research at the Global and National level.

The most crucial issues that emerged from the lead talks delivered by the eminent speakers from India and abroad were the major focus of discussions in different plenary and technical sessions. By discussing some of these issues from scientific perspectives, the conference could achieve its prime objective of disseminating the current knowledge on the prospects of probiotics as potential biotherapeutics in the management of human health and diseases.

[PubMed - as supplied by publisher]

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Pharmacol Res. 2012 Sep 24. pii: S1043-6618(12)00183-1. doi: 10.1016/j.phrs.2012.09.008. [Epub ahead of print]
Therapeutic modulation of intestinal dysbiosis.
Walker AW, Lawley TD.

Pathogen Genomics Group, Wellcome Trust Sanger Institute, Hinxton, UK. Electronic address: aw6@sanger.ac.uk.

The human gastrointestinal tract is home to an extremely numerous and diverse collection of microbes, collectively termed the "intestinal microbiota". This microbiota is considered to play a number of key roles in the maintenance of host health, including aiding digestion of otherwise indigestible dietary compounds, synthesis of vitamins and other beneficial metabolites, immune system regulation and enhanced resistance against colonisation by pathogenic microorganisms. Conversely, the intestinal microbiota is also a potent source of antigens and potentially harmful compounds.

In health, humans can therefore be considered to exist in a state of natural balance with their microbial inhabitants. A shift in the balance of microbiota composition such that it may become deleterious to host health is termed "dysbiosis". Dysbiosis of the gut microbiota has been implicated in numerous disorders, ranging from intestinal maladies such as inflammatory bowel diseases and colorectal cancer to disorders with more systemic effects such as diabetes, metabolic syndrome and atopy.

Given the far reaching influence of the intestinal microbiota on human health a clear future goal must be to develop reliable means to alter the composition of the microbiota and restore a healthy balance of microbial species. While it is clear that much fundamental research remains to be done, potentially important therapeutic options include narrow spectrum antibiotics, novel probiotics, dietary interventions and more radical techniques such as faecal transplantation, all of which aim to suppress clinical dysbiosis, restore intestinal microbiota diversity and improve host health.

Copyright 2012. Published by Elsevier Ltd.

[PubMed - as supplied by publisher]

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Reply Probiotics, Obesity, Diabetes Mellitus (Original post)
2on2u Dec 2012 OP
Fridays Child Dec 2012 #1
2on2u Dec 2012 #2
MFM008 Dec 2012 #3
postulater Dec 2012 #4
Celebration Dec 2012 #5
2on2u Dec 2012 #6

Response to 2on2u (Original post)

Thu Dec 27, 2012, 08:18 PM

1. Can you help out with a lay person-style summary?

Does this information indicate that people with obesity and/or diabetes should take a probiotic supplement?

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Response to Fridays Child (Reply #1)

Thu Dec 27, 2012, 08:22 PM

2. I cannot speak to that point. That is not the purpose of this board.... you may print out this


material and present it to your healthcare provider. More evidence for the potential benefits can be found by searching for "probiotics and " " at http://www.ncbi.nlm.nih.gov/pubmed

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Response to 2on2u (Original post)

Thu Dec 27, 2012, 09:13 PM

3. I heartily enorse Probiotics.

Before I would get sick twice a year every year, bronchitis, antibiotics without fail.
Since I have been taking them, Ive not had the flu or bronchitis when i get a cold, its mild and gone after a day or 2. My obesity is due to medication i have to take not probiotics , im not a diabetic, no high blood pressure. no sore throats, IBS better. I FEEL better.
You should try it and see if/how it works for you.
Look for the ones with 10 billion bacteria and mixed types like acidophilus, rhamnosus,bulgaricus,casei,Bifidobacteria bifidum, if this is to confusing yogurt or frozen yogurt works good to, but use it everyday.

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Response to 2on2u (Original post)

Fri Dec 28, 2012, 02:21 PM

4. Here's some more.


Pharmacol Res. 2012 Sep 16. pii: S1043-6618(12)00166-1. doi: 10.1016/j.phrs.2012.09.002. [Epub ahead of print]
Gut microbiota, immune development and function.
Bengmark S.
Division of Surgery & Interventional Science, University College London, 4th floor, 74 Huntley Street, London WC1E 6AU, United Kingdom. Electronic address: stig@bengmark.se.
The microbiota of Westerners is significantly reduced in comparison to rural individuals living a similar lifestyle to our Paleolithic forefathers but also to that of other free-living primates such as the chimpanzee. The great majority of ingredients in the industrially produced foods consumed in the West are absorbed in the upper part of small intestine and thus of limited benefit to the microbiota. Lack of proper nutrition for microbiota is a major factor under-pinning dysfunctional microbiota, dysbiosis, chronically elevated inflammation, and the production and leakage of endotoxins through the various tissue barriers. Furthermore, the over-comsumption of insulinogenic foods and proteotoxins, such as advanced glycation and lipoxidation molecules, gluten and zein, and a reduced intake of fruit and vegetables, are key factors behind the commonly observed elevated inflammation and the endemic of obesity and chronic diseases, factors which are also likely to be detrimental to microbiota. As a consequence of this lifestyle and the associated eating habits, most barriers, including the gut, the airways, the skin, the oral cavity, the vagina, the placenta, the blood-brain barrier, etc., are increasingly permeable. Attempts to recondition these barriers through the use of so called 'probiotics', normally applied to the gut, are rarely successful, and sometimes fail, as they are usually applied as adjunctive treatments, e.g. in parallel with heavy pharmaceutical treatment, not rarely consisting in antibiotics and chemotherapy. It is increasingly observed that the majority of pharmaceutical drugs, even those believed to have minimal adverse effects, such as proton pump inhibitors and anti-hypertensives, in fact adversely affect immune development and functions and are most likely also deleterious to microbiota. Equally, it appears that probiotic treatment is not compatible with pharmacological treatments. Eco-biological treatments, with plant-derived substances, or phytochemicals, e.g. curcumin and resveratrol, and pre-, pro- and syn-biotics offers similar effects as use of biologicals, although milder but also free from adverse effects. Such treatments should be tried as alternative therapies; mainly, to begin with, for disease prevention but also in early cases of chronic diseases. Pharmaceutical treatment has, thus far, failed to inhibit the tsunami of endemic diseases spreading around the world, and no new tools are in sight. Dramatic alterations, in direction of a paleolithic-like lifestyle and food habits, seem to be the only alternatives with the potential to control the present escalating crisis. The present review focuses on human studies, especially those of clinical relevance.

Copyright 2012 Elsevier Ltd. All rights reserved.

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Response to 2on2u (Original post)

Sat Dec 29, 2012, 08:42 AM

5. have a friend who had gestational diabetes

And high blood sugars were also being recorded way after pregnancy. She had a history of recurrent sinus infections (fungal, undoubtedly) and had had a few yeast infections. She had had digestive issues since childhood. Once she addressed her diet, eliminating sugar, etc., and adding many fermented products such as kefir, etc. she felt great, and all blood sugars returned to normal.

Since then I read a study showing that the incidence of gestational diabetes is greatly reduced in those that take probiotics.

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Response to Celebration (Reply #5)

Sat Dec 29, 2012, 09:21 AM

6. If they were a new drug you would see big pharma putting them on the telly 24/7. n/t


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