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Environment & Energy
Related: About this forumBPA exposure effects may last for generations
http://www.eurekalert.org/pub_releases/2012-06/tes-bee061412.php[font face=Serif]Public release date: 15-Jun-2012
Contact: Aaron Lohr
[email protected]
240-482-1380
The Endocrine Society
[font size=5]BPA exposure effects may last for generations[/font]
[font size=4]New study shows gestational exposure to BPA leads to behavioral changes for 4 generations[/font]
[font size=3]Chevy Chase, MDExposure to low doses of Bisphenol A (BPA) during gestation had immediate and long-lasting, trans-generational effects on the brain and social behaviors in mice, according to a recent study accepted for publication in the journal Endocrinology, a publication of The Endocrine Society.
BPA is a man-made chemical present in a variety of products including food containers, receipt paper and dental sealants and is now widely detected in human urine and blood. Public health concerns have been fueled by findings that BPA exposure can influence brain development. In mice, prenatal exposure to BPA is associated with increased anxiety, aggression and cognitive impairments.
"We have demonstrated for the first time to our knowledge that BPA has trans-generational actions on social behavior and neural expression," said Emilie Rissman, PhD, of the University of Virginia School of Medicine and lead author of the study. "Since exposure to BPA changes social interactions in mice at a dose within the reported human levels, it is possible that this compound has trans-generational actions on human behavior. If we banned BPA tomorrow, pulled all products with BPA in them, and cleaned up all landfills tomorrow it is possible, if the mice data generalize to humans, that we will still have effects of this compound for many generations."
In this study, female mice received chow with or without BPA before mating and throughout gestation. Plasma levels of BPA in supplemented female mice were in a range similar to those measured in humans. Juveniles in the first generation exposed to BPA in utero displayed fewer social interactions as compared with control mice. The changes in genes were most dramatic in the first generation (the offspring of the mice that were exposed to BPA in utero), but some of these gene changes persisted into the fourth generation.
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Contact: Aaron Lohr
[email protected]
240-482-1380
The Endocrine Society
[font size=5]BPA exposure effects may last for generations[/font]
[font size=4]New study shows gestational exposure to BPA leads to behavioral changes for 4 generations[/font]
[font size=3]Chevy Chase, MDExposure to low doses of Bisphenol A (BPA) during gestation had immediate and long-lasting, trans-generational effects on the brain and social behaviors in mice, according to a recent study accepted for publication in the journal Endocrinology, a publication of The Endocrine Society.
BPA is a man-made chemical present in a variety of products including food containers, receipt paper and dental sealants and is now widely detected in human urine and blood. Public health concerns have been fueled by findings that BPA exposure can influence brain development. In mice, prenatal exposure to BPA is associated with increased anxiety, aggression and cognitive impairments.
"We have demonstrated for the first time to our knowledge that BPA has trans-generational actions on social behavior and neural expression," said Emilie Rissman, PhD, of the University of Virginia School of Medicine and lead author of the study. "Since exposure to BPA changes social interactions in mice at a dose within the reported human levels, it is possible that this compound has trans-generational actions on human behavior. If we banned BPA tomorrow, pulled all products with BPA in them, and cleaned up all landfills tomorrow it is possible, if the mice data generalize to humans, that we will still have effects of this compound for many generations."
In this study, female mice received chow with or without BPA before mating and throughout gestation. Plasma levels of BPA in supplemented female mice were in a range similar to those measured in humans. Juveniles in the first generation exposed to BPA in utero displayed fewer social interactions as compared with control mice. The changes in genes were most dramatic in the first generation (the offspring of the mice that were exposed to BPA in utero), but some of these gene changes persisted into the fourth generation.
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BPA exposure effects may last for generations (Original Post)
OKIsItJustMe
Jun 2012
OP
twitter1
(18 posts)1. We are destroying our planet
Gore was right
flamingdem
(39,304 posts)2. He was as were many who have warned along the way
At this point it would take all of us working 24/7 and putting our lives on the line to slow it down.
People I know are so passive, they figure that humans will mutate and all will be well..
OKIsItJustMe
(19,933 posts)3. “…they figure that humans will mutate and all will be well…”
Ah! Just like the Clovis culture did!
https://en.wikipedia.org/wiki/Younger_Dryas_impact_hypothesis