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Wed Oct 5, 2022, 05:03 AM

Three scientists win Nobel Prize for chemistry for 'ingenious' molecule-building tool

Source: CNN

CNN — Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless have won the Nobel Prize for chemistry, for work that has produced “an ingenious tool for building molecules.” The trio won the award for founding and advancing the fields of click chemistry and bioorthogonal chemistry, which has “led to a revolution in how chemists think about linking molecules together,” the Royal Swedish Academy of Sciences said.

Click chemistry enables fast and straightforward reactions, where “molecular building blocks snap together quickly,” the committee said. The principle can bring real-world benefits in the development of pharmaceuticals and medicine, including more targeted cancer treatments.Sharpless and Meldal pioneered the concept before Bertozzi “took click chemistry to a new level,” the organizers said, by developing click reactions that work inside living organisms (or bioorthogonal reactions).

She told reporters at the winners’ press conference over the phone that her advancements are being used “to discover new kinds of molecules we didn’t know existed,” and means scientists are “doing chemistry inside human patients to make the drugs go to the right place.”

Bertozzi, who teaches at Stanford University in California, said she was told of her win in the middle of the night on the American west coast. “I can hardly breathe,” she said of her reaction. Sharpless, meanwhile, became the fifth person ever to win two Nobels, joining a short list that includes pioneering chemists Marie Curie and Frederick Sanger. He previously won the chemistry prize in 2001.

Read more: https://www.cnn.com/2022/10/05/europe/nobel-prize-chemistry-winner-2022-scn-intl/index.html






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BREAKING NEWS:
The Royal Swedish Academy of Sciences has decided to award the 2022 #NobelPrize in Chemistry to Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless "for the development of click chemistry and bioorthogonal chemistry."
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5:47 AM · Oct 5, 2022


Article being updated.

Original article -

CNN -- Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless have won the Nobel Prize for chemistry, for work that has produced "an ingenious tool for building molecules."

The trio won the award for founding and advancing the fields of click chemistry and bioorthogonal chemistry, which has "led to a revolution in how chemists think about linking molecules together," the Royal Swedish Academy of Sciences said.

Click chemistry enables fast and straightforward reactions, where "molecular building blocks snap together quickly," the committee said. The principle can bring real-world benefits in the development of pharmaceuticals.

The Nobels are being awarded throughout the week; the prizes for medicine and physics were announced on Monday and Tuesday.

This is a breaking story. More details soon...

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Reply Three scientists win Nobel Prize for chemistry for 'ingenious' molecule-building tool (Original post)
BumRushDaShow Oct 5 OP
dalton99a Oct 5 #1
BumRushDaShow Oct 5 #2
jmowreader Oct 5 #4
BumRushDaShow Oct 6 #5
Duppers Oct 5 #3

Response to BumRushDaShow (Original post)

Wed Oct 5, 2022, 06:29 AM

1. Very interesting biographies

https://en.wikipedia.org/wiki/Carolyn_R._Bertozzi

Carolyn Bertozzi received her A.B. summa cum laude in chemistry from Harvard University, where she worked with Professor Joe Grabowski on the design and construction of a photoacoustic calorimeter.[12] While an undergraduate, she played in various bands. Her most notable one was Bored of Education, which included future Rage Against the Machine guitarist Tom Morello.[13][14] After graduating, she worked at Bell Labs with Chris Chidsey.[15]

Bertozzi completed her Ph.D. in chemistry at University of California, Berkeley in 1993 with Mark Bednarski, working on the chemical synthesis of oligosaccharide analogs.[16] While at Berkeley, she discovered that viruses can bind to sugars in the body.[17] The discovery led her to her current field of research, glycobiology. During Bertozzi's third year of graduate school, Bednarski was diagnosed with colon cancer, which resulted in him taking a leave of absence and changing his career path by enrolling in medical school. This left Bertozzi and the rest of the lab to complete their Ph.D. work with no direct supervision.[18]


https://en.wikipedia.org/wiki/Karl_Barry_Sharpless

Sharpless married Jan Dueser in 1965 and they have three children.[8] He was blinded in one eye during a lab accident in 1970 where an NMR tube exploded, shortly after he arrived at MIT as an assistant professor. After this accident, Sharpless stresses "There's simply never an adequate excuse for not wearing safety glasses in the laboratory at all times.”[16]

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Response to dalton99a (Reply #1)

Wed Oct 5, 2022, 06:50 AM

2. "He was blinded in one eye during a lab accident in 1970 where an NMR tube exploded"

Yikes. Don't know how well the "safety glasses" would work in that situation but maybe full goggles would have been best. But then I don't think chemists expect the emission/detector tubes to explode either although I suppose since they are vacuum tubes, the possibility is there.

We had a NMR in our lab although it wasn't used that much (we mostly used UV/VIS and/or Fluorescence).

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Response to BumRushDaShow (Reply #2)

Wed Oct 5, 2022, 10:38 PM

4. I was thinking more on the order of a face shield

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Response to jmowreader (Reply #4)

Thu Oct 6, 2022, 03:00 AM

5. Well there are also times when things are done in the hood

and the doors on that are designed to contain a certain level of explosion, so that helps mitigate as well.

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Response to dalton99a (Reply #1)

Wed Oct 5, 2022, 07:16 AM

3. WOW!!!

Very impressive, well-rounded lady.

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