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Tue Oct 15, 2013, 04:51 AM

Scientists Found a Compound That Keeps Marijuana From Getting You High

Tetrahydrocannabinol, or THC, is the dopamine-boosting compound in marijuana that, technically speaking, "induces euphoria" — science jargon for "gets you high." It also happens to work on the brain region involved in psychological addiction. Now, a team of researchers has identified a substance that blocks THC's dopamine effect. Why is that important? Let's have a grown-up discussion about weed.



We've already written about the mechanics behind how marijuana makes you feel. But you may be surprised to find out that in the United States, over a million people sought treatment for marijuana dependence in 2009 (Figure 7.8), nearly as many as did for cocaine and heroin combined. While the Marijuana Policy Project points out that 57% of those receiving treatment in the U.S. did so in lieu of serving a prison sentence, people still seek anti-dependence treatment in countries like the Netherlands where marijuana use has been decriminalized.

Like most drugs with addictive potential, THC works by increasing dopamine levels in the "reward centers" of the brain (the ventral tegmental area and the nucleus accumbens). A team led by researchers at the University of Maryland School of Medicine and the National Institute on Drug abuse found that the drug Ro 61-8048 blocks THC's ability to stimulate dopamine production in the brain's reward centers. Without dopamine, there's no neurological reward to the drug, and no drive to continue using it.

The researchers taught squirrel monkeys to self-administer THC by pushing a lever. Once the monkeys exhibited signs of addiction (in this case, frequent lever pushing), Ro 61-8048 reduced the reward effect of continual THC doses, leading the monkeys to stop seeking additional doses. The same behavior was seen in rats that were taught to dose themselves with WIN 55,212-2, a synthetic THC substitute.

Oops forgot the link: http://gizmodo.com/scientists-found-a-compound-that-keeps-marijuana-from-g-1445168058

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Arrow 20 replies Author Time Post
Reply Scientists Found a Compound That Keeps Marijuana From Getting You High (Original post)
madokie Oct 2013 OP
Warren DeMontague Oct 2013 #1
madokie Oct 2013 #2
PeteSelman Oct 2013 #3
TreasonousBastard Oct 2013 #4
arcane1 Apr 2015 #20
Laelth Oct 2013 #5
GreenPartyVoter Oct 2013 #7
madokie Oct 2013 #8
ProdigalJunkMail Oct 2013 #11
KurtNYC Oct 2013 #12
ProdigalJunkMail Oct 2013 #13
Laelth Oct 2013 #15
GreenPartyVoter Oct 2013 #6
hobbit709 Oct 2013 #9
LaydeeBug Oct 2013 #10
bemildred Oct 2013 #14
bemildred Oct 2013 #18
KurtNYC Oct 2013 #16
Fumesucker Oct 2013 #17
Uththara Apr 2015 #19

Response to madokie (Original post)

Tue Oct 15, 2013, 05:03 AM

1. Caffeine also works on the reward centers, but no one is trying to pretend it is some evil scourge

on mankind.

Sorry, this article has some glaringly obvious problems.

Unlike some other drugs, there is currently no medical treatment for psychological dependence on marijuana.


Okay, I'll bite: What "other drugs" have medical treatment for "psychological dependence", one wonders? I call bullshit. And if the dependence is "psychological", why would marijunana need a specific pharmacalogical agent to address it, as opposed to these alleged wonder cures for other "psychological" addictions?


A 'grown up' discussion? Yes, let's. Let's talk about the toxicity of THC. None. Let's talk about the evidence that marijunana is in any way, shape, or form, physically addictive the way- say- alcohol can be. Or Heroin. Or nicotine.

I've seen alcoholics in the potentially life-threatening throes of the DTs. People who try to pass off the drug war lie that "addiction" to marijuana is anywhere close to the same sort of animal, are pushing an agenda.

Look, if someone want to stop- hell, anything they're doing compulsively, be it gambling, or sniffing drainpipes, or smoking pot... awesome. If this is something they want, and they ask for, to help them improve their lives; great.


However if the powers that be are looking to "solve" the "problem" of literally hundreds of millions of humans recreationally smoking pot the way they have for thousands of years, trying desperately to come up with some high-priced big pharma "answer" that can be pushed instead of legalization, taxation, and regulation of consenting adult use, sorry, fuck that.

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Response to Warren DeMontague (Reply #1)

Tue Oct 15, 2013, 05:12 AM

2. To me I only see the absurdity of it

Hell I smoked the evil weed for 40 plus years, many of them day in and day out and about 6 months ago I quit. Decided I didn't want to smoke it anymore, gave what I had to a friend and threw the pipe in the trash. Oh I thought about it a few times afterwards but not to the point I just had to go find some to smoke.
People who discover shit like this article have nothing better to do with their time is my guess.

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Response to madokie (Original post)

Tue Oct 15, 2013, 05:43 AM

3. Great. Invent something utterly useless.

What's next? Aspirin that doesn't take away your headache? Shouldn't these guys be doing something helpful?

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Response to madokie (Original post)

Tue Oct 15, 2013, 06:04 AM

4. What on earth would be the point of that?

Lessee-- monkeys discover they can get high pushing a lever so they start pushing the pot lever a lot. Big surprise there. Even bigger surprise is they stopped pushing the lever when they stopped getting high. Isn't science wonderful?

What would be the addiction if they were rapidly pushing a blueberry lever? Or any of us and a chocolate lever?

My first thought is that this is blatant grant chasing and the appropriate "results" of this project will get the geniuses behind it more funds to fight drug abuse. Lots more funds.

Marijuana dependence? Is that like tobacco dependence where millions more pay good money to stop smoking? How about the many millions more who pay good money for everything from diet plans to stomach banding because of their "food dependence".

There are addictions and there are habits, and there are areas where they cross and may be indistinguishable-- shouldn't some of this research be for more insights how this works and how to make our lives more worthwhile in general, rather than look at the specific "addiction" of the moment"?






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Response to TreasonousBastard (Reply #4)

Tue Apr 21, 2015, 04:33 PM

20. If I lived in a lab cage, I'd press the lever too. ANY lever! n/t

 

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Response to madokie (Original post)

Tue Oct 15, 2013, 06:40 AM

5. OT, but the graphic in the OP is absolutely brilliant. Excellent artwork. n/t

-Laelth

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Response to Laelth (Reply #5)

Tue Oct 15, 2013, 07:25 AM

7. It's beautiful.

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Response to Laelth (Reply #5)

Tue Oct 15, 2013, 08:09 AM

8. Yes it is

For shits and grins I just put it on my desktop

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Response to Laelth (Reply #5)

Tue Oct 15, 2013, 08:20 AM

11. My first reaction to the thread was going to be

why the hell would anyone spend time searching for a compound to set aside the BENEFITS of smoking weed... but then I saw the graphic and that overwhelmed my first thought. VERY nice work...

sP

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Response to Laelth (Reply #5)

Tue Oct 15, 2013, 08:24 AM

12. They use death imagery in alcohol ads but pot has no lethal dose

The alcohol sellers are appealing to the death wish of their best customers but MJ is non-addictive and won't kill you so I don't see the point of putting death next to MJ. However, it fits well with the bullshit article's retro Reefer Madness angle.

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Response to KurtNYC (Reply #12)

Tue Oct 15, 2013, 08:25 AM

13. the image is very suggestive

but from a purely artistic it is well done...

sP

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Response to KurtNYC (Reply #12)

Tue Oct 15, 2013, 08:28 AM

15. In that respect, I do have a bit of a negative reaction to the image.

I do not think THC leads to death in any way, nor do I think it's honest to equate the two. Alcohol is far more deadly. As far as I know, THC isn't deadly at all.

That said, the art is still gorgeous, and, mercifully, the Grateful Dead neutralized the death imagery with some of their art. I don't equate skulls and death as a result.



-Laelth

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Response to madokie (Original post)

Tue Oct 15, 2013, 07:25 AM

6. Would this be useful for medical users, or do you need the dopamine effect to treat them?

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Response to madokie (Original post)

Tue Oct 15, 2013, 08:12 AM

9. That's right up there with the heatless jalapeno pepper.

I know quite a few people that smoke pot daily. If they run out, they go "Oh well" and continue with their business. They don't go frantic trying to find a fix.

About 10 years ago a friend got busted for pot and they made him go to AA meetings. When he stood up at the meeting and said "My name is John and I'm here because I got busted for smoked pot" everyone had that WTF look on their faces.

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Response to madokie (Original post)

Tue Oct 15, 2013, 08:17 AM

10. NOOOoooooooooooooooooooo!!!!!!

 

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Response to madokie (Original post)

Tue Oct 15, 2013, 08:28 AM

14. I share the "Why would you want to do that?" sentiment.

However, cannabis has many effects, and I could see not wanting the euphoria effect, sometimes you have to function at a high level, but it's always good to be calm.

As far as addiction, anything that makes you feel good is "addictive" by their definition. There is nothing about withdrawal, which is the classic indicator of addiction, i.e. physical dependency. I'll bet they can do the same thing with sugar, for example.

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Response to bemildred (Reply #14)

Tue Oct 15, 2013, 07:35 PM

18. College study finds Oreo cookies are as addictive as drugs

If you’ve ever been unable to stop yourself from eating too many Oreo cookies it may not be your fault--a new college study says one of America’s favorite desserts is just as addictive as drugs in lab rats.

The study by students at Connecticut College found that when the rats ate Oreos they formed an equally strong association with the cookies as when other rats were injected with cocaine or morphine.

Additionally, researchers found eating the cookies activated even more neurons in the rats’ brain “pleasure centers” than the addictive drugs.

“Our research supports the theory that high-fat/ high-sugar foods stimulate the brain in the same way that drugs do,” Neuroscience Professor Joseph Schroeder said in a school press release. “It may explain why some people can’t resist these foods despite the fact that they know they are bad for them.”

http://www.foxnews.com/health/2013/10/15/college-study-finds-oreo-cookies-are-as-addictive-as-drugs/

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Response to madokie (Original post)

Tue Oct 15, 2013, 08:29 AM

16. In my experience, only people with addictive personalities consider themselves "addicted" to MJ

While this compound, if it is ever marketed by big pharma, may stop these people from using MJ it will NOT address their addictive mode of behavior. They will likely substitute activity in their other addictions which may well be worse health wise and much riskier -- sex, gambling, cocaine, meth, adrenaline, rage, alcohol and (shudder)... FaceBook.

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Response to madokie (Original post)

Tue Oct 15, 2013, 08:33 AM

17. In other news: Congress finds scientific research subject that is totally acceptable to both parties

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Response to madokie (Original post)

Tue Apr 21, 2015, 03:02 PM

19. Very interesting

This is very interesting. People may think it makes no sense, but could be useful in medical practices in treating certain conditions without having the patients get high!

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