US Gov National Cancer Center admits Pot kills Cancer Cells

[green for victory]

This ought to put an end to any further nonsense about how Pot is Not Medicine

Next time Holder or another Prohibitionist says: "There is no medical use for Marijuana" you will know beyond a shadow of a doubt that they are not only lying, they are deceiving.



http://www.cancer.gov/cancertopics/pdq/cam/cannabis/patient/page2

Have any preclinical (laboratory or animal) studies been conducted using Cannabis or cannabinoids?

Preclinical studies of cannabinoids have investigated the following activities:

Antitumor activity

Studies in mice and rats have shown that cannabinoids may inhibit tumor growth by causing cell death, blocking cell growth, and blocking the development of blood vessels needed by tumors to grow. Laboratory and animal studies have shown that cannabinoids may be able to kill cancer cells while protecting normal cells.

A study in mice showed that cannabinoids may protect against inflammation of the colon and may have potential in reducing the risk of colon cancer, and possibly in its treatment.

A laboratory study of delta-9-THC in hepatocellular carcinoma (liver cancer) cells showed that it damaged or killed the cancer cells. The same study of delta-9-THC in mouse models of liver cancer showed that it had antitumor effects. Delta-9-THC has been shown to cause these effects by acting on molecules that may also be found in non-small cell lung cancer cells and breast cancer cells.

A laboratory study of cannabidiol in estrogen receptor positive and estrogen receptor negative breast cancer cells showed that it caused cancer cell death while having little effect on normal breast cells.

Stimulating appetite

Many animal studies have shown that delta-9-THC and other cannabinoids stimulate appetite and can increase food intake.

Pain relief

Cannabinoid receptors (molecules that bind cannabinoids) have been studied in the brain, spinal cord, and nerve endings throughout the body to understand their roles in pain relief.

Cannabinoids have been studied for anti-inflammatory effects that may play a role in pain relief.

Have any clinical trials (research studies with people) of Cannabis or cannabinoid use by cancer patients been conducted?

No clinical trials of Cannabis as a treatment for cancer in humans have been found in the CAM on PubMed database maintained by the National Institutes of Health.

Cannabis and cannabinoids have been studied in clinical trials for ways to manage side effects of cancer and cancer therapies, including the following:

Nausea and vomiting

Delta-9-THC taken by mouth: Two cannabinoid drugs approved in the United States are available under the names dronabinol and nabilone. Both dronabinol and nabilone are approved by the Food and Drug Administration (FDA) for the treatment of chemotherapy -related nausea and vomiting in patients who have not responded to standard therapy. Many clinical trials have shown that both dronabinol and nabilone worked as well as or better than some of the weaker FDA-approved drugs to relieve nausea and vomiting. Newer drugs given for chemotherapy-related nausea have not been directly compared with Cannabis or cannabinoids in cancer patients.

Inhaled Cannabis: Three small trials have studied inhaled Cannabis for the treatment of chemotherapy-related nausea and vomiting. Various study methods and chemotherapy agents were used with mixed results. There is not enough information to interpret these findings.

Stimulating appetite

Delta-9-THC taken by mouth: A clinical trial compared delta-9-THC (dronabinol) and a standard drug (megestrol) in patients with advanced cancer and loss of appetite. Results showed that delta-9-THC was not as effective in increasing appetite or weight gain in advanced cancer patients compared with standard therapy. However, a clinical trial of patients with HIV/AIDS and weight loss found that those who took delta-9-THC had increased appetite and stopped losing weight compared with patients who took a placebo.

Inhaled Cannabis: There are no published studies of the effect of inhaled Cannabis on cancer patients with loss of appetite. Studies of healthy people who inhaled Cannabis showed that they consumed more calories, especially high-fat and sweet snacks.

Pain relief

Combining cannabinoids with opioids: In a small study of 21 patients with chronic pain, vaporized Cannabis was added to slow-release oxycodone or morphine and given for five days. Results showed that combining vaporized Cannabis with morphine relieved pain better than morphine alone, while combining vaporized Cannabis with oxycodone did not produce significantly greater pain relief. These findings should be tested in further studies.

Delta-9-THC taken by mouth: Two small clinical trials of oral delta-9-THC showed that it relieved cancer pain. In the first study, patients had good pain relief as well as relief of nausea and vomiting and better appetite. A second study showed that delta-9-THC could be given in doses that gave pain relief comparable to codeine. Higher doses of delta-9-THC were found to be more sedating than codeine. An observational study of nabilone also showed that it relieved cancer pain along with nausea, anxiety, and distress when compared with no treatment. Neither dronabinol nor nabilone is approved by the FDA for pain management.

Whole Cannabis plant extract medicine: A study of a whole-plant extract of Cannabis that contained specific amounts of cannabinoids, which was sprayed under the tongue, found it was effective in patients with advanced cancer whose pain was not relieved by strong opioids alone. This treatment was studied using different doses in a randomized, placebo-controlled clinical trial of cancer patients with chronic pain not controlled by opioids. Patients who received the lower doses of cannabinoid spray showed markedly better pain control and less sleep loss compared with patients who received a placebo. Adverse side effects depended on the dose received. Only patients in the high-dose group had adverse side effects that made the treatment less beneficial than the placebo.

Inhaled Cannabis: A study of inhaled Cannabis in patients with HIV -related peripheral neuropathy found better pain control in the Cannabis group than in the placebo group. To date, no clinical trials have studied cannabinoids in the treatment of chemotherapy-related neuropathy in patients with cancer.

Anxiety and sleep

Inhaled Cannabis: A small case series found that patients who inhaled marijuana had improved mood, improved sense of well-being, and less anxiety.

Whole Cannabis plant extract spray: A trial of a whole-plant extract of Cannabis that contained specific amounts of cannabinoids, which was sprayed under the tongue, found that patients had improved sleep quality.

See all the references to Cannabinoids?

That's why the Feds took out a patent on the use of cannabinoids in 2003. That's right, while raiding legal dispensaries in CA, the feds have held a patent on the use of the main ingredient in Cannabis.

Federal Medical Marijuana Prisoners and Cases
http://www.canorml.org/costs/federal_medical_marijuana_prisoners_and_cases
click to see Pending Cases in California and Elsewhere

This paper at the National Cancer Center should end the debate. But it won't, because too few people will see it and understand the depth of the deception on this herb.

This guy, the King of Hemp
managed to change the world...

And get the last laugh. If only
he could see it now
RIP KoH

[Recursion]

1. No

I wish people would learn to read studies

[green for victory]

13. From the National Cancer Institute:

A laboratory study of delta-9-THC in hepatocellular carcinoma (liver cancer) cells showed that it damaged or killed the cancer cells.

So,


Yes

[Recursion]

21. Step 1: learn the difference between "cannabinoids" and "pot"

We can address the rest of your misunderstandings then.

[Downtown Hound]

31. Nitpicky bullshit.

Do you get cannabinoids in your body if you smoke pot? Yes.

Do cannabinoids kill cancer cells? Yes.

Does this mean that pot kills cancer cells? Yes.

Are you going to spend the next thirty posts trying to convince us otherwise? Probably.

Is it a bullshit and ridiculous waste of time on your part? Yes.

[Recursion]

33. Sigh

Do you get all cannabinoids in your body if you smoke pot? No.

Have all cannabinoids been shown to kill cancer cells? No.

Has the delivery mechanism of the cannabinoid been shown not to matter? No.

Does that mean we can't say pot kills cancer cells? Yes.

Are you going to spend the next thirty posts trying to justify getting high as healthy and virtuous? Yes.

Cannabinoids are a broad class of chemicals. Some are found in marijuana, many are not.

[Downtown Hound]

46. Since you're not very informed, allow me to educate you

There has been a movement within the last few years among medical marijuana growers to increase CBD and other medical cannibinoids in their product. As the research into marijuana has increased, thanks in no small part to it being more tolerated, our understanding of it has increased and so has the desire to produce better, more medicinal weed.

And so fucking what if getting high makes people, especially sick people, feel better? Is that such a bad thing? Keep your bullshit, moralistic, craptacular judgements to yourself. No one really gives a fuck if you have a problem with it.

[Gato Moteado]

53. +10000000000000000000

party on!

[wildbilln864]

49. Montana Dad Gives Cancer-Stricken Boy Marijuana Behind Doctor's Back

"Cash, now 3, made a miraculous recovery at Primary Children's Hospital in Salt Lake City, but his father's bold action -- taken behind doctors' backs -- has raised serious questions about a parent's role in medical treatment. "
more here...

[DisgustipatedinCA]

35. Caustic, wrong, and unnecessary

I hate to sound so stereotypical, but you could use a mellow buzz.

[Mason Kennedy]

2. Misleading

Because in the same page, we are told the following about studies on humans instead of animals:

Q: "Have any clinical trials (research studies with people) of Cannabis or cannabinoid use by cancer patients been conducted?

A: No clinical trials of Cannabis as a treatment for cancer in humans have been found in the CAM on PubMed database maintained by the National Institutes of Health."

Not including this key portion was a mistake in your part.

[green for victory]

44. "Not including this key portion was a mistake in your part."

But I did include that.

If you look at the OP under Pain Relief, right after Stimulating Appetite you should see it.

Unless your screen is showing something different.

This leads me to believe that you didn't read the post. But thanks for the kick.

[Mason Kennedy]

45. Why did you unbold the information about it not being tested in humans?

I sure hope the intention was not to take attention away from this key question, whose importance was highlighted by the bold letters.

Interesting, you did not turn any of the other bold subtopics into regular font.

To guide readers' eyes away from important information is misleading. The headline, by the way, should read, "US Gov National Cancer Center admits Pot kills certain animals' Cancer Cells".

[onehandle]

3. Missed a bit...

'At this time, there is not enough evidence to recommend that patients inhale or ingest Cannabis as a treatment for cancer-related symptoms or side effects of cancer therapy'

http://www.cancer.gov/cancertopics/pdq/cam/cannabis/patient

And...

Have any side effects or risks been reported from Cannabis and cannabinoids?
Adverse side effects of cannabinoids may include:

Rapid beating of the heart.
Low blood pressure.
Muscle relaxation.
Bloodshot eyes.
Slowed digestion and movement of food by the stomach and intestines.
Dizziness.
Depression.
Hallucinations.
Paranoia.
Because Cannabis smoke contains many of the same substances as tobacco smoke, there are concerns about how smoked cannabis affects the lungs. A study of over 5,000 men and women without cancer over a period of 20 years found that smoking tobacco was linked with some loss of lung function but that occasional and low use of cannabis was not linked with loss of lung function.

Because use of Cannabis over a long time may have harmful effects on the endocrine and reproductive systems, rates of testicular germ cell tumors (TGCTs) in Cannabis users have been studied. Larger studies that follow patients over time and laboratory studies of cannabinoid receptors in TGCTs are needed to find if there is a link between Cannabis use and a higher risk of TGCTs.

Both Cannabis and cannabinoids may be addictive.

Symptoms of withdrawal from cannabinoids may include:

Irritability.
Trouble sleeping.
Restlessness.
Hot flashes.
Nausea and cramping (rarely occur).
These symptoms are mild compared to withdrawal from opiates and usually lessen after a few days.

[green for victory]

4. 'At this time, there is not enough evidence to recommend that patients inhale or ingest Cannabis as

They haven't even begun to award the pieces of the patent. Once the patent has been sliced and diced out to all the good Pharma companies, they will change their lies

Feds To Grant Exclusive Cannabinoid License To Pharma Firm

The U.S. federal government's Department of Health and Human Services seems about ready to award exclusive rights to apply marijuana as a medical therapeutic. You read that correctly: "exclusive rights."

Now, I don't think of myself as a conspiracy theorist. But when the federal government keeps taking actions that, even when considered separately but especially when viewed together, all seem to be part of a bigger plan to pave the way for the pharmaceutical industry to bulldoze the cottage medical marijuana industry, I start getting antsy....MORE

http://www.tokeofthetown.com/2011/12/feds_to_grant_exclusive_cannabinoid_license_to_pha.php

[onehandle]

5. 'seems about ready to award' That 'news' is from over a year ago.

Which Big Pharma is offering that product? I'm seeing my doctor this week and might want to inquire.

[green for victory]

11. they have awarded a piece of the patent to

Kannalife

I didn't have time to search for the post that explains it when I posted the OP.

Cannabinoid Patent Exclusivity Only Applies To One Condition
http://www.tokeofthetown.com/2011/12/cannabinoid_patent_exclusivity_only_applies_to_one.php

It may be "old news" but few here know about it. Thanks for kicking my post.


Dean Petkanas, CEO, KannaLife: "Our exclusivity is narrowly focused"

[Comrade Grumpy]

8. Marijuana has side effects? Oh, lordy, get me to my fainting couch!

Compare marijuana's side effects to those of those Big Pharma blockbusters they advertise on TV.

[onehandle]

9. Who luckily are compelled to disclose in their advertising and in delivery.

The original OP, not so much, even though that government glossary did it for them.

[DisgustipatedinCA]

36. Right...because of Sudden Weed Death Syndrome and Weed Fetal Disease

The danger will be lurking everywhere it's convenient for you to find it.

[Comrade Grumpy]

48. You can't regulate what you prohibit, so no pot warning labels for you.

[bvar22]

15. Compare those side effect to the use of alcohol,

especially the "withdrawal symptoms".

[Downtown Hound]

32. My sister is an alcoholic

who has this rather bad habit of relapsing. When she goes through withdrawls while drying out, it's not pretty. She shakes, she cries, she hallucinates, she hears things that aren't there, she sweats, she throws up, she looks like a zombie from Dawn of the Dead. You name it, she does it.

When I or anybody else I know stops smoking pot, even if use of it has been excessive, the worst that happens is minor crankiness and maybe some trouble sleeping at first. And now they're saying that even moderate alcohol use can increase your cancer risk significantly.

Now compare the two: one drug helps fight cancer, the other causes it. One drug has mild withdrawl symptoms, the other extreme. One drug regularly causes incidents of violence and car accidents, the other, not so much. One drug has numerous environmental and industrial benefits, the other doesn't.

Leave it to America to choose the harmful drug to be legal and the other one to be a jailable offense.

[ThomThom]

22. glad it doesn't cause annal leakage

cures my depression does not cause depression

[Scuba]

6. This is not news, just not reported. I captured this screenshot a year or so ago ...

[green for victory]

41. NIce work capturing that screen shot!

"This is not news, just not reported."

Maybe it's just me, but I was thinking that the US Gov recognizing the fact publicly that Cannabinoids kill cancer cells is pretty big news.

Yes some people knew in 1974, but there wasn't any public paper about it.

In 1974 researchers learned that THC, the active chemical in marijuana, shrank or destroyed brain tumors in test mice. But the DEA quickly shut down the study and destroyed its results, which were never replicated -- until now. May 30, 2000 |

The term medical marijuana took on dramatic new meaning in February, 2000 when researchers in Madrid announced they had destroyed incurable brain tumors in rats by injecting them with THC, the active ingredient in cannabis.

and some people confirmed it in 2000

Active Ingredient in Marijuana Kills Brain Cancer Cells Experts say finding worth further study, but patients shouldn't light up just yet

WEDNESDAY, April 1 (HealthDay News) -- New research out of Spain suggests that THC -- the active ingredient in marijuana -- appears to prompt the death of brain cancer cells.
http://health.usnews.com/health-news/family-health/cancer/articles/2009/04/01/active-ingredient-in-marijuana-kills-brain-cancer

The finding is based on work with mice designed to carry human cancer tumors, as well as from an analysis of THC's impact on tumor cells extracted from two patients coping with a highly aggressive form of brain cancer.

Explaining that the introduction of THC into the brain triggers a cellular self-digestion process known as "autophagy," study co-author Guillermo Velasco said his team has isolated the specific pathway by which this process unfolds, and noted that it appears "to kill cancer cells, while it does not affect normal cells."

Now it's right in front of everyone's eyes. So Holder and the usual suspects should not be able to use the "Marijuana has no medical use" BS ever again.

But they will, and those who call themselves "Reporters" will all look foolish. Won't they? Because surely "Reporters" can do a little basic research and find this info. They're so good at what they do. (/s)

[Webster Green]

7. RIP Jack.

Thanks for including him in your post.

He was my friend and my hero.

[Buddyblazon]

40. Herer was the man...

he changed my life.

[green for victory]

42. I got to hang with him very briefly

and smoke with him in his apartment in north Van Nuys or whatever that region is calling itself now. He had graduated from the Ice Cream Truck to a '78 (or something) Blue Chevy Van. It was almost kind of surreal, here's the guy that is changing the world but don't walk on his carpet without socks!

It was an experience I will never forget. He was a True Patriot and someone with Real Guts that never backed down and never publicly showed a hint of negativity. A True Leader.

He deserved so so much more. While bankers and the like have almost ruined our economy, he was there to show a way forward.

Jack Herer: A Patriots Patriot. Thank You Jack!

Jack's Rallying cry:

Hemp for
Food
Fiber
Fuel and
Medicine!

The Emperor Wears No Clothes

[Webster Green]

47. Last time I saw him was a few years before he died.

I went to visit him in the hospital in Santa Rosa, CA. Smuggled in a couple of goodies for him.

I met him through mutual friends in the cannabis/hemp activist community. My involvement actually preceded Jack's by many years, if not decades, but Jack was the man!!

[green for victory]

12. The Feds publicly deny any medical use for cannabis

while kids are being pumped full of dangerous drugs, drugs that are the common link in every school shooting save perhaps one in KY

If we're going to talk about abuse, let's start with something that, in the warnings that come with the pills, may cause violent behavior.

[Revanchist]

20. Yet they prescribe it.

Got to love government hypocrisy.

http://www.oregonlive.com/pacific-northwest-news/index.ssf/2011/09/us_government_provides_marijua.html

Anyone looking for more information on the subject there's an excellent book on the subject titled "Prescription Pot" that was written with the aid of one of the people who was in the program.

Edit: Tried to insert the website as a link but it wouldn't work for me, I'm still trying to learn the nuances of this site.

[Webster Green]

52. It's so absurd.

It's an easy argument to make that cannabis is the most useful plant known to man, yet it's use is widely prohibited.

Makes no sense at all.

[pscot]

14. Take that, all you Harry J. Anslinger wannabees

[riverbendviewgal]

16. It is so true

I can vouch for it. Smoking pot helped my dying husband and son with their pain from cancer and also helped with their appetite.
It helped them cope with dying, giving them a sense of calm and peacefulness without being doped up.

It only takes a couple tokes to take away most of the pain. That little.

[green for victory]

43. sorry for your loss, riverbendviewgal

but glad that they were able to be helped by the Miracle Plant.

[riverbendviewgal]

50. Thank you Green for victory

so many others I know were helped too.

I think the problem is that cannabis is cheap...one can grow it without any help. It grows anywhere. That is why it is called a weed.

Greed wins out . So much money in the crime fighting,, law enforcement, lawyers, judges, prisons, parole officers .

Now being in debt is starting to reap the same "profits" for those same people who reap them from pot smokers.


Funny that my friend in the early 1970s was arrested for smoking pot in another person home. Her lawyer told her everyoe smokes it, lawyers, judges, police.....
It is hypocrisy The rich can do anything they want.
.

[bvar22]

17. Well THAT explains why I'm still alive...

...given my family background and genetic predisposition.
Those who frowned on my "lifestyle" are all dead.

[Viva_La_Revolution]

38. I beat cervical cancer in 2004

you betcha I'm gonna keep tokin! (which I didn't very often before the diagnosis)

[GoneOffShore]

18. I see that the nay sayers have already shown up.

Quelle surprise.

[SCVDem]

19. These people want studies???

Just ask any of the millions of us who have been partaking for over 40 years!

Any questions?

[Go Vols]

23. Cannabis Oil Pills Helped Child Go Into Cancer Remission, Mom Says

When 7-year-old Mykayla Comstock was diagnosed with leukemia in July, it was less than three days before her mother filed Oregon medical marijuana paperwork so the child could take lime-flavored capsules filled with cannabis oil.

http://abcnews.go.com/Health/medical-marijuana-year-sparks-controversy/story?id=17814636

Medical marijuana helps stem 6-year-old's seizures

Oakland, California (CNN) -- Six-year-old Jayden David violently shakes on the ground, his blue eyes vacant and then filled with searing pain. The video shows an unvarnished look at a seizure, something Jayden once experienced routinely.

Not anymore, says his father, thanks to medical marijuana.

Before he started taking a liquid, nonpsychoactive form of marijuana, Jayden couldn't walk, eat solid food or take a bath

http://www.cnn.com/2012/12/10/health/medical-marijuana-child



There are lots of similar stories out there.

[Recursion]

34. Vaccine Caused Child to Develop Autism, Mom Says

"Mom Says" is a very bad source, generally.

[Downtown Hound]

54. So is somebody named Recursion. n/t

[Fire Walk With Me]

24. Isn't this supposed to be a free market economy? They have a monopoly. n/t

[dixiegrrrrl]

25. Which is why pot will not be legal.

Fortunately, millions of people the world around know pot has a beneficial use,
and many know you can't just isolate a few chemicals from an herb and call it good..
most herbs, including pot, have dozens of chemicals in them which work in a synergistic manner.

[Fire Walk With Me]

26. But monopolies are illegal in the US. There should be a mass lawsuit. n/t

[EastKYLiberal]

27. Good find, OP. Pay no attention to the moronic opponents of the safest drug on the planet. nt

[SCVDem]

28. Take a beneficial plant...

add processing and you've created yet another expensive poison.

Sometimes you just have to let things be!

[NightWatcher]

29. Pass it over here. I'm nauseous from my chemo pill and have inflammation

in my hands from the fucking lupus and dermatomyositis. Every night I go to sleep hoping that I don't start to throw up while I sleep. Only happened 3 of the last 7 nights.

Oh well, guess I'll try to eat some saltine crackers and have a sprite.

[spartan61]

30. Big pharma is and will continue to fight against

the healing and comforting aspects of cannabis, especially THC oil made from the plant. Why you ask??? It's because the large pharmaceutical companies cannot patent a plant, so they can't make billions on this like they can with viagra. We have known for years that marijuana has healing properties, so it's time we put this knowledge to good use and do something beneficial for cancer patients instead of poisoning them with chemo and burning them with radiation. My husband has brain cancer and I would do anything to have him treated with THC. Check out the utube video called Run from the Cure. Watch and listen to Rick Simpson who has extracted the oil and just a small amount on the inside of your cheek can melt cancer away. It's time we get serious about the fight against cancer. We are losing too many people to his horrific disease.

[green for victory]

39. "the large pharmaceutical companies cannot patent a plant"-- but the FEDS have patented

the use of cannabinoids.

It's right here. I know it's kind of hard to believe, but the facts are there.

Now they are awarding pieces of that patent. "Exclusivity" being the key word.
http://www.tokeofthetown.com/2011/12/cannabinoid_patent_exclusivity_only_applies_to_one.php

This has gone on right in front of everyone's eyes.

Here's the company that has been awarded the first cut of the patent.
Kannalife

The exclusive rights to apply the cannabinoids found in marijuana as therapeutic agents awarded by the U.S. federal government to the firm KannaLife only apply to one specific medical condition, KannaLife's CEO told Toke of the Town Monday night.

Dean Petkanas, chief executive officer at KannaLife Sciences, told us that the exclusivity applies only for the development and sale of cannabinoid based therapeutics as antioxidants and neuroprotectants for use in the treatment of hepatic encephalopathy.

If "The Feds" hold a patent on the use of cannabinoids, doesn't it really belong to the people of the US?

Rick Simpson's Run From the Cure

[Warren DeMontague]

37. See???? It's DEADLY! IT KILLS! IT KILLS! KILLS!!!!....

...um, cancer cells.

SEE? IT KILLS!

[wildbilln864]

51. and a kick! nt