General Discussion
Related: Editorials & Other Articles, Issue Forums, Alliance Forums, Region ForumsHuman ageing process biologically reversed in world first
Current BS aside, this is really cool news...
Updated Link:
https://news.yahoo.com/human-ageing-process-biologically-reversed-153921028.html
qazplm135
(7,447 posts)so can't open.
underpants
(182,734 posts)shelshaw
(533 posts)KewlKat
(5,624 posts)MizLibby
(289 posts)Human ageing process biologically reversed in world first
Pioneering research has found way to turn back clock on frailty and ill-health by putting humans in chambers with pure oxygen
By
Sarah Knapton,
SCIENCE EDITOR
18 November 2020 6:47pm
Test subjects were placed in hyperbaric chambers for 90 minutes for five days a week over three months
The ageing process has been biologically reversed for the first time by giving humans oxygen therapy in a pressurised chamber.
Scientists in Israel showed they could turn back the clock in two key areas of the body believed to be responsible for the frailty and ill-health that comes with growing older.
As people age, the protective caps at the ends of chromosomes called telomeres shorten, causing DNA to become damaged and cells to stop replicating. At the same time, "zombie" senescent cells build up in the body, preventing regeneration.
Increasing telemere length and getting rid of senescent cells is the focus of many anti-ageing studies, and drugs are being developed to target those areas.
Now scientists at Tel Aviv University have shown that giving pure oxygen to older people while in a hyperbaric chamber increased the length of their telomeres by 20 per cent, a feat that has never been achieved before.
Scientists said the growth may mean that the telomeres of trial participants were now as long as they had been 25 years earlier.
The therapy also reduced senescent cells by up to 37 per cent, making way for new healthy cells to regrow. Animal studies have shown that removing senescent cells extends remaining life by more than one third.
"Since telomere shortening is considered the 'Holy Grail' of the biology of ageing, many pharmacological and environmental interventions are being extensively explored in the hopes of enabling telomere elongation," said Professor Shai Efrati of the Faculty of Medicine and Sagol School of Neuroscience at Tel Aviv University.
"The significant improvement of telomere length shown during and after these unique protocols provides the scientific community with a new foundation of understanding that ageing can indeed be targeted and reversed at the basic cellular-biological level."
Many scientists now believe ageing itself is responsible for major conditions such as Alzheimer's, Parkinson's, arthritis, cancer, heart disease, and diabetes.
It is also known that obesity, smoking, lack of physical activity, vitamin deficiency and inflammation can speed up the shortening of telomeres, demonstrating that they have a major impact on longevity.
Micrograph of human chromosomes with yellow dye marking location of telomeres
Micrograph of human chromosomes with yellow dye marking location of telomeres CREDIT: Los Alamos National Laboratory
The trial included 35 healthy independent adults aged 64 and older who did not undergo any lifestyle, diet or medication adjustments. Each patient was placed in a hyperbaric chamber for 90 minutes for five days a week over three months while breathing 100 per cent oxygen through a mask.
The pressurised chamber allows more oxygen to be dissolved into the tissues and mimics a state of "hypoxia", or oxygen shortage, which is known to have regenerating effects.
Previous trials have shown that eating a healthy diet can preserve telomere length, while high-intensity training for six months has been proven to lengthen telomeres by up to five per cent.
The Israeli team has also previously demonstrated that the pressurised oxygen therapy can improve cognitive decline.
"Until now, interventions such as lifestyle modifications and intense exercise were shown to have some inhibition effect on the expected telomere length shortening," said Dr Amir Hadanny, chief medical research officer of the Sagol Center for Hyperbaric Medicine and Research.
"However, what is remarkable to note in our study is that, in just three months of therapy, we were able to achieve such significant telomere elongation at rates far beyond any of the current available interventions or lifestyle modifications.
"With this pioneering study, we have opened a door for further research on the prolonged cellular impact of the therapy to reverse the ageing process. After dedicating our research to exploring its impact on the areas of brain functionality and age-related cognitive decline, we have now uncovered, for the first time in humans, biological effects at the cellular level in healthy ageing adults."
The research was published in the journal Ageing.
qazplm135
(7,447 posts)will result in "de-aging."
There's certainly a link, but we will need to follow these subjects over time to see if there's actual "de-aging"
robbob
(3,524 posts)I dont think its a new treatment. Maybe proving it works is a new discovery...
Bettie
(16,083 posts)that means evil billionaires will now never die.
ooky
(8,921 posts)A billion per wrinkle should just about wipe Sheldon Adelson out.
PirateRo
(933 posts)And while it might be expensive at the start, it will get cheaper and better over time.
lpbk2713
(42,751 posts)PirateRo
(933 posts)roamer65
(36,745 posts)It may slow the process, but it wont stop it.
PirateRo
(933 posts)Not a big fan of death, it screws up my schedule and is generally a big inconvenience. Who has the time?
Volaris
(10,269 posts)PirateRo
(933 posts)...and unbreakable?
DrToast
(6,414 posts)There's a decent chance we'll be able to reverse aging in the next 10-20 years. It's pretty amazing.
Lifespan: Why We Age - and Why We Don't Have To
PirateRo
(933 posts)Thanks for the book, Ill look into it.
triron
(21,994 posts)2naSalit
(86,508 posts)I don't get that. Everyone has to go sometime, it's inevitable.
ARPad95
(1,671 posts)after my expiration date is good for me or the rest of the world. I want (healthy) longevity, not immortality.
Iwasthere
(3,158 posts)I want to slide into my grave like it's home base. A healthy whole food diet extends life as well, but Oxygen therapy is Huge for telemeres! I had mine tested a year ago. Mine came out very short. My cell age tested at 49 years old, I am 63
spinbaby
(15,088 posts)Theres a theory called compression of morbidity, in which you extend, not your lifespan, but your active lifespan through exercise.
ARPad95
(1,671 posts)do the type of activities I do now a year ago without a lot of aches and pains. I feel 20 years younger than I am.
Silent3
(15,183 posts)If we manage to get off fossil fuels and take care of the environment (big ifs, I know), there's a lot of interesting things coming up for humanity. I don't want to live forever, but I'd certain enjoy hanging around to see travel to other planets, or even other star systems. I'd especially love it if I could live long enough to not just take advantage of live-extension technology, but rejuvenation technology.
If I'm healthy and the world continues to be an interesting place, why check out so soon?
panader0
(25,816 posts)Shit like this and cryogenics will be available for the very rich and self obsessed people.
abqtommy
(14,118 posts)put up with it forever.