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Wed Mar 25, 2020, 09:47 AM

Malaria Drug Chloroquine No Better Than Regular Coronavirus Care, Study Finds

Hydroxychloroquine, a medicine for malaria that President Donald Trump has touted as a treatment for coronavirus, was no more effective than conventional care, a small study found.

The report published by the Journal of Zhejiang University in China showed that patients who got the medicine didn’t fight off the new coronavirus more often than those who did not get the medicine.

The study involved just 30 patients. Of the 15 patients given the malaria drug, 13 tested negative for the coronavirus after a week of treatment. Of the 15 patients who didn’t get hydroxychloroquine, 14 tested negative for the virus.

The results of the study weren’t statistically significant.

https://www.bloomberg.com/news/articles/2020-03-25/hydroxychloroquine-no-better-than-regular-covid-19-care-in-study?sref=6SIErc4i



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Response to demmiblue (Original post)

Wed Mar 25, 2020, 09:50 AM

1. So much for Dr. Trump's advice

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Response to Yo_Mama_Been_Loggin (Reply #1)

Wed Mar 25, 2020, 09:58 AM

2. He'll still take it anyway to prove them wrong.

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Response to demmiblue (Original post)

Wed Mar 25, 2020, 10:02 AM

3. Not surprised because the French study was so sketchy

and the authors of the study were so unhelpful when asked about specifics. Six people dropped out, some because they went to ICU, others due to intolerable side effects.

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Response to Mike 03 (Reply #3)

Wed Mar 25, 2020, 10:50 AM

6. The search goes on for prophylactic medications to protect against COVID -19....

... to protect first responders, medical personnel as doctors, nurses, CNAs, respiratory therapists etc. so that they do not succumb to the virus or die while being treated in the hospital ICU ward.

Until the vaccine comes out about a year or year and one half from now it would be nice to have prophylactic medications tested and ready for the elderly, asthma sufferers, those with COPD, those currently using hand held inhalers, those pron to bronchitis etc. - many of these COVID -19 patients get pneumonia, are placed on ventilators, yet die because this virus is too strong for them to fight off or for their other morbidity factors to be overcome.

The search for any medications or off label use of medications is currently being done world wide to prevent needless death from this virus.

What is a prophylactic medication ?


Prophylactic: A preventive measure. The word comes from the Greek for "an advance guard," an apt term for a measure taken to fend off a disease or another unwanted consequence.

A prophylactic is a medication or a treatment designed and used to prevent a disease from occurring.

Such as COVID - 19.

*******

The CDC is working on this issue and the race to find helpful drugs

There are no US Food and Drug Administration (FDA)-approved drugs specifically for the treatment of patients with COVID-19.  At present clinical management includes infection prevention and control measures and supportive care, including supplementary oxygen and mechanical ventilatory support when indicated.  An array of drugs approved for other indications as well as several investigational drugs are being studied in several hundred clinical trials that are underway across the globe. The purpose of this document is to provide information on two of the approved drugs (chloroquine and hydroxychloroquine) and one of the investigational agents (remdesivir) currently in use in the United States.

Remdesivir
Remdesivir is an investigational intravenous drug with broad antiviral activity that inhibits viral replication through premature termination of RNA transcription and has in-vitro activity against SARS-CoV-2 and in-vitro and in-vivo activity against related betacoronaviruses [1-3].

There are currently four options for obtaining remdesivir for treatment of hospitalized patients with COVID-19 and pneumonia in the United States:

A National Institutes of Health (NIH)-sponsored adaptive double-blinded, placebo-controlled trial of remdesivir versus placebo in COVID-19 patients with pneumonia and hypoxia is enrolling non-pregnant persons aged 18 years and older with oxygen saturation of ≤94% on room air or requiring supplemental oxygen or mechanical ventilation (https://clinicaltrials.gov/ct2/show/NCT04280705external icon). Exclusion criteria include alanine aminotransaminase or aspartate aminotransaminase levels >5 times the upper limit of normal, stage 4 severe chronic kidney disease or a requirement for dialysis (i.e., estimated glomerular filtration rate (eGFR) <30);

Much more at link below,

https://www.cdc.gov/coronavirus/2019-ncov/hcp/therapeutic-options.html

***********

The World Health Organization (WHO) announced a large global trial, called SOLIDARITY, to find out whether any can treat infections with the new coronavirus for the dangerous respiratory disease. It’s an unprecedented effort—an all-out, coordinated push to collect robust scientific data rapidly during a pandemic. The study, which could include many thousands of patients in dozens of countries, has been designed to be as simple as possible so that even hospitals overwhelmed by an onslaught of COVID-19 patients can participate.

With about 15% of COVID-19 patients suffering from severe disease and hospitals being overwhelmed, treatments are desperately needed. So rather than coming up with compounds from scratch that may take years to develop and test, researchers and public health agencies are looking to repurpose drugs already approved for other diseases and known to be largely safe. They’re also looking at unapproved drugs that have performed well in animal studies with the other two deadly coronaviruses, which cause severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS).

https://www.sciencemag.org/news/2020/03/who-launches-global-megatrial-four-most-promising-coronavirus-treatments

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Response to demmiblue (Original post)

Wed Mar 25, 2020, 10:06 AM

4. Too bad the medicine was not effective, I hope something is found to be and soon.

I was just thinking about that couple in AZ that found old fish parasite cleaning solution containing a similar ingredient, and self medicated to horrible results. He died and she got seriously sick. Sad and crazy at the same time. This is like someone drinking contact lens solution instead of gatorade for dehydration because they both contain sodium choloride.

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Response to demmiblue (Original post)

Wed Mar 25, 2020, 10:47 AM

5. not true - the results are statistically significant

The results, when added to other formal test data, prove that Trump is an idiot. There is also strong corollary data that the trump family is somehow profiting from sales of these drugs.

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Response to demmiblue (Original post)

Wed Mar 25, 2020, 11:07 AM

7. A prevaricating liar and habitual fabricator of reality like Donald J.Trump...

... is so dangerous to have in place as our leader because he constantly lies and embellishes the truth nobody knows what to believe any more.

We need off label pharmaceuticals to fight this Coronavirus 19 until a vaccine comes out, which will take more than a year.

We can not just stand by and watch people die. We need drug studies done for off label application of current medications to fight COVID - 19. Japan, South Korea, France, and China are looking for existing drugs to help these virus infected patients.

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Response to demmiblue (Original post)

Wed Mar 25, 2020, 11:12 AM

8. I hold out more hope for the anti-viral drug Remsidivir.

It blocks one of the enzymes the virus needs to replicate. They're testing about 50 drugs hopefully something works.

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Response to demmiblue (Original post)

Wed Mar 25, 2020, 11:21 AM

9. Inconclusive study because the negative control standard of care was quite effective

14 out of 15 patients got better, so no drug could have seen to have worked in comparison. Chloroquine/hydroxychloroquine needs to be tested against a greater number of more serious cases that did not respond,

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