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The Straight Story Donating Member (1000+ posts) Send PM | Profile | Ignore Wed Dec-07-11 06:08 AM
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Valproate Exposure Associated With Autism, Lower IQ
Valproate Exposure Associated With Autism, Lower IQ

BALTIMORE In utero exposure to valproate appears to increase the risk of significant adverse effects on fetal brain development that persist into childhood.

In two separate studies, children whose mothers took valproate during pregnancy had a higher risk for lower IQ and other cognitive deficiencies, as well as autism and other disorders along the autistic spectrum. "All women with epilepsy of childbearing potential should be informed of the risks. I feel that valproate should not be a first choice antiepileptic drug in women of childbearing potential," Dr. Kimford J. Meador, director of the Emory Epilepsy Center and professor of neurology at Emory University, Atlanta, said in an interview.

The cognition data come from the NEAD (Neurodevelopmental Effects of Antiepileptic Drugs) study, a prospective observational study that enrolled pregnant women who were using any of several antiepileptic-drug monotherapies from October 1999 through February 2004 in 25 epilepsy centers in the United States and the United Kingdom. Dr. Meador and his colleagues previously published interim NEAD data showing impaired cognitive function in 309 offspring at 3 years of age (N. Engl. J. Med. 2009;360:1597-1605).

In June 2011, the Food and Drug Administration issued a safety alert about the increased risk of impaired cognitive development in children exposed to valproate products in utero.

But, how can this be? It was made by scientists and approved by peer review, etc? If I don't trust this med it means I am anti-science (Am I doing this right? :rofl: )
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