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SIV Gets More Complicated (Herd Health) Sunday, July 25, 2004

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seemslikeadream Donating Member (1000+ posts) Send PM | Profile | Ignore Sat May-02-09 10:10 PM
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SIV Gets More Complicated (Herd Health) Sunday, July 25, 2004
http://www.porkmag.com/directories.asp?pgID=677&ed_id=2...


".....According to Marie Gramer, Veterinary Diagnostic Medicine, University of Minnesota, the new reassortant H1N1 strains are adding to the confusion about SIV and contributing to problems surrounding its control.

Multiple strains active in a herd on a nearly continual basis make SIV testing more complicated, says Gramer. Its difficult to identify strains definitively using only the basic testing procedures.

Its possible for one herd to carry multiple SIV strains including H1N1, rH1N1, H1N2 and H3N2, stresses Gramer. To identify multiple strains in a herd the diagnostic lab must do genetic sequencing of the virus in addition to performing serotyping.

Today, SIV is a moving target, says Gene Erickson, Rollins Laboratory, Raleigh, N.C., with the emergence of H3N2, it has become clear that the virus has a broad ability to reassort with other strains of virus co-circulating in the herd, at the same time allowing it to create a new virus.

Were seeing documented cases in well-vaccinated pigs where the SIV vaccine hasnt offered adequate protection, acknowledges Gramer. The vaccine didnt necessarily fail, it just didnt cover new strains circulating within the herd....'


"....Since 1998, SIV has moved from a single, stable virus to a virus with the ability to reconfigure itself to the point where it may avoid control by existing vaccines.


The new H1N1 strain emerged from a process called genetic reassortment, which occurs when a single cell is infected by two different influenza viruses, explains Robyn Fleck, a technical service veterinarian at Schering-Plough Animal Health. The result is a progeny virus containing genetic material from both parents.

In other words, she adds, the outside of reassortment H1N1 looks like a classical H1N1, but its internal genes are derived from H3N2. Reassortant H1N1 also acts differently from the old classical H1N1. It picks up mutations at an increased rate, thereby evading the pigs immune system.

According to Bruce Janke, Veterinary Diagnostic Laboratory, Iowa State University, the positive identification of H3N2 in 1998 made SIV a two-strain disease in many Midwest herds within 6 months, thus setting the stage for further variations.'
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