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Scientists Say They've Found Cure For Alzheimers

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Contrary1 Donating Member (1000+ posts) Send PM | Profile | Ignore Sat Aug-25-07 08:20 PM
Original message
Scientists Say They've Found Cure For Alzheimers
Fingers crossed...this sounds promising.

"Scientists believe they have discovered a “cure” for Alzheimer’s, the devastating illness that affects nearly 600,000 people in the UK.

For years experts have been looking for a way of preventing the debilitating brain condition. Now British and American ­scientists have found a way of halting its spread.

<snip>

One of the researchers described the breakthrough as “blindingly simple”.

Alzheimer’s is caused when amyloid – a chemical that naturally occurs in the bloodstream – passes into the brain. Once there it forms plaques that harden. These damage communication between brain cells and eventually cause brain cell death.

Scientists have discovered a synthetic human protein that is capable of soaking up amyloid –preventing it leaking into the brain..."

http://www.dailyexpress.co.uk/posts/view/16839
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Swede Donating Member (1000+ posts) Send PM | Profile | Ignore Sat Aug-25-07 08:23 PM
Response to Original message
1. I have an uncle with it.
He is forgetting everything that happened in his life.
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Cabcere Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 05:54 PM
Response to Reply #1
82. I'm sorry to hear that, Swede.
:hug: My grandmother is in the last stages of Alzheimer's, and it is a cruel disease. :pals:
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Joe Bacon Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 06:42 PM
Response to Reply #1
87. Please let this be true!
All of my mother's sisters developed Alzheimer's and Mom was so scared she would get it. I saw how it tore her apart before she passed away and I just pray that this ends so much suffering!
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LiberalFighter Donating Member (1000+ posts) Send PM | Profile | Ignore Sat Aug-25-07 08:34 PM
Response to Original message
2. Just don't let any of the Bush family get the cure
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melody Donating Member (1000+ posts) Send PM | Profile | Ignore Sat Aug-25-07 08:59 PM
Response to Reply #2
9. It only works on humans n/t
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devilgrrl Donating Member (1000+ posts) Send PM | Profile | Ignore Sat Aug-25-07 10:04 PM
Response to Reply #9
24. That's a DUzy if there ever was one!
Edited on Sat Aug-25-07 10:05 PM by devilgrrl
:rofl:
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LiberalFighter Donating Member (1000+ posts) Send PM | Profile | Ignore Sat Aug-25-07 10:22 PM
Response to Reply #9
28. Good to know... what happens when they are not human?
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melody Donating Member (1000+ posts) Send PM | Profile | Ignore Sat Aug-25-07 11:48 PM
Response to Reply #28
34. You don't want to know. It's unspeakably awful. n/t
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LiberalFighter Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 10:37 AM
Response to Reply #34
42. Have they already tested on some non-human subjects such as the Bush family
or the wacko Republicans?
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pitohui Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 01:20 PM
Response to Reply #9
54. it only works on mice actually
i see nothing to suggest it has worked on a human subject ?
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SmokingJacket Donating Member (1000+ posts) Send PM | Profile | Ignore Mon Aug-27-07 11:53 AM
Response to Reply #54
125. If the proteins are chemically the same...
I don't see why it wouldn't work on humans.
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skul_Donteecha Donating Member (70 posts) Send PM | Profile | Ignore Sun Aug-26-07 12:39 PM
Response to Reply #2
51. To hell with the Bush family.
Dont let the religious fundies get hold of it. They will claim God wants our brains to rot and thats why he created alzheimers and we must not go against God's wishes. Before you know it, Wingnuts will be blowing up Alzheimer research labs and shooting scientists. And they they will try to outlaw use and sale of the drug thru groups they will call "Right To Die" Orgs. And we will all have to go to Canada to buy the stuff for our ailing relative.

How long, Oh Lord......How long?????
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Raster Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 07:00 PM
Response to Reply #2
92. I don't think it works on rats.

Wake up America!:kick:

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saltpoint Donating Member (1000+ posts) Send PM | Profile | Ignore Sat Aug-25-07 08:41 PM
Response to Original message
3. Contrary1, I'll follow your lead and cross my fingers on this one...
Edited on Sat Aug-25-07 08:45 PM by Old Crusoe
... it sounds as if it offers some hope where up to this point there's been precious little hope to be had.

Thanks for posting this.
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HughMoran Donating Member (1000+ posts) Send PM | Profile | Ignore Sat Aug-25-07 08:43 PM
Response to Original message
4. I sure hope this is for real
This is one dreadful disease.
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annabanana Donating Member (1000+ posts) Send PM | Profile | Ignore Sat Aug-25-07 08:43 PM
Response to Original message
5. Damn I hope this is as good as it sounds.
There is some history in our family, and I'm watching my Dad with some trepidation.. .
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BlooInBloo Donating Member (1000+ posts) Send PM | Profile | Ignore Sat Aug-25-07 08:44 PM
Response to Original message
6. (shrug) Scientists also say the earth is billions of years old....
... You gonna believe them, or you gonna believe GOD???
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BlooInBloo Donating Member (1000+ posts) Send PM | Profile | Ignore Sat Aug-25-07 08:48 PM
Response to Reply #6
7. Article looks like pure magic bullet bullshit to me.
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melody Donating Member (1000+ posts) Send PM | Profile | Ignore Sat Aug-25-07 09:00 PM
Response to Reply #7
10. Actually, the science on this is pretty sound
Mainly because it's very simple.

I want to see more on it, but it looks promising.
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Contrary1 Donating Member (1000+ posts) Send PM | Profile | Ignore Sat Aug-25-07 09:17 PM
Response to Reply #10
15. Here's a bit more detail:
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Divine Discontent Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 04:10 PM
Response to Reply #6
71. it's actually...
'or you gonna believe those who claim to know the history of the universe!'

I like to say, God knows full well just how old the universe is and he enjoys our attempts at guessing... the greatest of scientists is God, I never understood fundies who refute scientific evidence as being hogwash!
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clydefrand Donating Member (1000+ posts) Send PM | Profile | Ignore Sat Aug-25-07 08:53 PM
Response to Original message
8. Thank you for this article
It's too late for my sister who has AD, but it might help many of us.
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emilyg Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 12:17 PM
Response to Reply #8
49. Too late for my Dad, too.
Let's hope.
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petersjo02 Donating Member (1000+ posts) Send PM | Profile | Ignore Sat Aug-25-07 09:12 PM
Response to Original message
11. Thanks for posting
I've just sent your OP with link to a friend whose mom is currently undergoing testing for Alzheimer's. Very timely.
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purduejake Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 01:28 PM
Response to Reply #11
56. Tragically it often takes many years to test treatments...
FDA approval seems to be tediously slow and they don't like to give treatments to people outside of the study group, even for people who are "terminal."
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backscatter712 Donating Member (1000+ posts) Send PM | Profile | Ignore Sat Aug-25-07 09:12 PM
Response to Original message
12. Pharmco's are going to put big bucks in this
They're going to rework and rework this synthetic protein until it only slows the progression of the disease down a little, and they can charge $10,000 per bottle, for ten years straight.

After all, there's no money in cures...
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bbinacan Donating Member (1000+ posts) Send PM | Profile | Ignore Sat Aug-25-07 09:20 PM
Response to Reply #12
16. Oh good grief. n/t
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BreweryYardRat Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 08:28 PM
Response to Reply #16
102. Sadly, I think he's got a point.
He's exaggerating the pricing, but he's got a point. My pharmacology class last year, had an instructor who'd worked/dealt with dozens of different companies, and he said that it does yield higher profits to come up with something that won't cure, just stave off the effects.
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backscatter712 Donating Member (1000+ posts) Send PM | Profile | Ignore Mon Aug-27-07 11:53 AM
Response to Reply #102
126. You think I'm exaggerating the pricing?
Edited on Mon Aug-27-07 11:55 AM by backscatter712
Have you seen how much chemotherapy and AIDS treatments cost these days? Yes, they literally charge thousands of dollars a dose. It's insane!
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AllyCat Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 12:10 PM
Response to Reply #12
48. That sounds like healthcare and business in Murka!
Welcome to DU!
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orleans Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 01:21 PM
Response to Reply #12
55. true. big pharma says NO to cure. n/t
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EFerrari Donating Member (1000+ posts) Send PM | Profile | Ignore Sat Aug-25-07 09:15 PM
Response to Original message
13. One of my aunts was recently diagnosed. Thank you for posting.
I'm sending it to my cousins.

:hi:
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AZBlue Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 09:58 PM
Response to Reply #13
112. Sorry to hear that!
:hug:
Hope they make this available to all very soon!!
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sarcasmo Donating Member (1000+ posts) Send PM | Profile | Ignore Sat Aug-25-07 09:15 PM
Response to Original message
14. This is great news, but with our terrible health care system. I ask 2 Questions.
What will be the cost? How long will it take to get to the public?
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MatrixEscape Donating Member (1000+ posts) Send PM | Profile | Ignore Sat Aug-25-07 09:50 PM
Response to Reply #14
21. Getting to the public is a moot point when
you have to ask, who, amongst the public will get it?

We have heard that they can now charge what they want for medications because, well, they can!

So, since science, (in this odd dimension) is not altruistic, and we know that many people and families who can afford to, (or are insured adequately enough) will pay the going price, we can assume that we can only be hopeful about this potential cure if it can be accessed by everyone who needs it.

Sadly, we see that many wonderful, new technologies are out of reach for growing numbers of people. If you are poor and without insurance, do you get the latest tests, the triple-bypass, or the transplant? Without any form of social consideration for health-care, (as dubious as some health care may be) then the people who can be optimistic and excited about ground-breaking technology are the ones who have the wealth to partake in it, one way or another.
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irislake Donating Member (967 posts) Send PM | Profile | Ignore Sun Aug-26-07 12:54 PM
Response to Reply #21
52. Hey if this is true
Edited on Sun Aug-26-07 12:57 PM by irislake
(and however awful the vices depicted in SICKO I doubt that your health establishment would be so evil that they would withhold the cure from the poor) why wouldn't you be marching in the streets? You could have MM lead you in a demonstration outside insurance offices or whatever. I don't think Americans should take so many of these things lying down. We get furious at our politicians when they get out of line and so should you. However, you can't dump them out of office before their term is up. What a pity. They are more responsive to the will of the people if they have a minority government and could be dumped any time they get too far out of line.

You sound pretty hopeless. Buck up!
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MatrixEscape Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 11:40 PM
Response to Reply #52
114. You are correct!
Thanks for the uplifting words and support there!

There should be more action and reaction to the disproportionate access to health care we have here.

Our problem, IMHO, is not just our current, somewhat elected officials, though. Our problem seems to by wide-sweeping, systematic, and deeply entrenched.

To sum it up, our government supports corporations and big business first and foremost. They benefit from doing so. The well-vested corporate interests can throw the best lobbyists at them that money can buy. There are many financial and career incentives for politicians with wanton pockets.

Our corporations have personhood. Therefore, they have the same rights as people do and can react and behave as such, (even as exercising our rights becomes more difficult and questionable). With those kinds of rights and the kind of power and control that corporations have due to their strong ties with government, (one could say that the US government, as a corporation itself, is more like a subsidy of the corporate sphere) and large financial clout, they trump the people's voice and needs.

As you can see, the insurance industry decides what we get and if we get it. The profit motivations of both the Big-Pharmaceutical companies dominates both the prices of medicines and what diseases will be researched and treated. The for-profit aspects of Hospitals and medical services take precedence over the patients.

We really need to uproot this mess because it is turning out to be more and more obvious that it is a situation where our illness serves to fulfill the needs of the industries involved and NOT the other way around.

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Frisbee Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 04:27 PM
Response to Reply #14
75. I would imagine
How much it will cost will depend on what country you live in. Here in the US, probably more than anyone on a fixed income can afford, and surely it will be considered "experimental" for quite some time by the insurance industry, meaning they don't have to pay for it. And whatever you do, don't try to import any of those UNSAFE MEDS FROM CANADA, only trust those coming in LEGALLY FROM CHINA, which have been approved by the FDA!
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bicentennial_baby Donating Member (1000+ posts) Send PM | Profile | Ignore Sat Aug-25-07 09:25 PM
Response to Original message
17. That's nice...I wish they could cure ALS too...
x(
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Pachamama Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 03:05 AM
Response to Reply #17
36. I wish they would have a cure for ALS as well...what a horrible way to die..
I have known two people in the last several years who were diagnosed with it...

Watching two people who used to be incredible athletes and active wither away at young ages (44 and 48) has been awful....

I hear that Alzheimers' is awful too, but probably mostly for the family members and friends who get forgotten and watch their loved one forget everything and change. ALS victims are completely aware of all going on, but their bodies wither away and they lose control. It's awful.
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emilyg Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 12:19 PM
Response to Reply #36
50. Horrible for the person who has it, too.
Dad had lucid moments and they were painful to watch.
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StarryNite Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 06:13 PM
Response to Reply #50
84. You are so right.
In the beginning stages it must be horrible for the person who has it. They know they are mentally slipping. They can become frustrated with themselves and can often become abusive towards those they love. In the beginning my mother-in-law was always trying to get back home. That may not sound too bad on the surface except that she lives in Arizona and would try to walk back to New York where she grew up, still trying to find her mom and dad who had died decades earlier. At times she thought her husband of over 60 years was a stranger who was holding her captive. Over the past four years she has regressed to the point of not knowing much of anything. When her husband died two years ago she wasn't even aware she had lost him. She doesn't know she has two sons or grandchildren. I would say her mental age is equivalent to that of an eight month old baby now. She is still able to walk and put food in her mouth but that's about it.

So while I wish there were potential cures on the horizon for other diseases too, we have to hope this one works out. It's a terrible disease. Watching your loved one regress into infancy during their final years is not fun.
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emilyg Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 07:00 PM
Response to Reply #84
93. Every time I changed Dad's diapers
I wept. How our roles reversed.
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bicentennial_baby Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 09:39 PM
Response to Reply #36
111. I know, my Mom has it...
Sigh....and my Dad has MS. Life's a bowl of fucking cherries, eh?

x(
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retread Donating Member (1000+ posts) Send PM | Profile | Ignore Mon Aug-27-07 04:49 AM
Response to Reply #36
118. My dad died from ALS. An awful thing to see happen to a loved one. Infinitely
worse for the loved one.
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bigtree Donating Member (1000+ posts) Send PM | Profile | Ignore Sat Aug-25-07 09:39 PM
Response to Original message
18. just a few years earlier and we could have saved dad
aricept came on right when he was diagnosed. it did as well as it could, better than nothing at all - at least for a while.

Good news
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mopinko Donating Member (1000+ posts) Send PM | Profile | Ignore Sat Aug-25-07 09:46 PM
Response to Original message
19. incredibly irresponsible reporting
anything that is still in the mouse stages of research is NOT A CURE FOR ANYTHING! jesus h christ.
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arikara Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 01:35 PM
Response to Reply #19
57. Don't I know it
But it isn't actually "reporting", its a press release from a pharmaceutical company disguised as reporting and the media plops it in as a filler to cover for the fact that they no longer do any actual reporting. They do that all the time.

My dad has dementia and I've seen this f***'ing bloody cruel press release countless times over the past few years. They've always isolated something and some pill or other will be available over the next 10 or 15 years. Bastards. It probably won't work anyhow but they'll make a killing off it just the same.

Of course they would never work on prevention because they wouldn't make any money if we all stayed healthy.

Anyone who is interested in cheap, available prevention should read this book by Dr Harold Foster. He's ignored because his treatments are safe, cheap and non-patentable. The books are available for sale, or free download http://www.hdfoster.com/ Scroll halfway down the page for the books. He also has information on ms, aids and schizophrenia.
Unfortunately, its too late for Dad.


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mopinko Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 02:00 PM
Response to Reply #57
59. quack
real ideas don't need vanity publishers. and real theories get tested before they are published. this guy is a quack.
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mconvente Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 02:45 PM
Response to Reply #59
67. Exactly - just like Gary Trudeau
That "Natural Cures They Don't Want you to know about" crap. Wikipedia that guy - you'll find he is a convicted felon and he can't sell any not-text products (1st Amendment rights).

Trust true academic science research.
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LeftishBrit Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 04:07 PM
Response to Reply #67
70. I think you mean Kevin Trudeau - and I fully agree with you about him
Gary Trudeau is the creator of 'Doonesbury' and is great!
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Posteritatis Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 05:44 PM
Response to Reply #70
81. I wouldn't want him giving me an appendectomy either!
;)
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mconvente Donating Member (1000+ posts) Send PM | Profile | Ignore Mon Aug-27-07 02:34 PM
Response to Reply #70
128. oh yeah! OOPS!!
Thanks for the correction! I move back to college tomorrow so my mind is elsewhere... haha

:hi:
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SidDithers Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 09:23 PM
Response to Reply #67
109. You're right...
real scientific research doesn't get published in a Doonsebury cartoon :)

Sid
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arikara Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 03:17 PM
Response to Reply #59
68. He is not a quack
and I suggest you look at the material before jumping to conclusions.
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mopinko Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 05:36 PM
Response to Reply #68
78. yeah, i did.
a bunch of self published books and articles in a quack journal. quack quack quack.

sorry, just sort of a pet peeve of mine, having lost a niece to quackery. nice slow painful death, too. not much pain control in quackdom.
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arikara Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 06:16 PM
Response to Reply #78
85. What I said stands
you didn't have time to read anything. I've lost people to the medical quacks too... slow painful deaths as you say.

Big pharma does studies, skews the results their way and publishes their lies. Just because its in a mainstream journal doesn't make it any more true. They are the real quacks.

Quack quack quack.
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mopinko Donating Member (1000+ posts) Send PM | Profile | Ignore Mon Aug-27-07 10:02 AM
Response to Reply #85
121. he isn't even an md!
his phd is in GEOGRAPHY! ferchrissakes.
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Sam Ervin jret Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 06:27 PM
Response to Reply #78
86. With due respect, you need to re-research, Journals of Neurochemistry, Biochemistry and
Trends in Biochemistry Magazine may not be fun time reading (for you) but they are not "quack journals." A scientist gives reporters interviews about his/her latest research. That writer then has the last say in how he/she represents the scientist's work.

In order to get the real "scoop" on the work you need these "quack" journals that the scientist originally wrote his information in.
Getting the information second hand is paramount to playing the kids game "telephone" with a bunch of kids that do not speak the language of science.

But "there is the rub," we need the writers in the more "mainstream" media to get the science news out to the people who need it, but we are not always the ones in charge of that information once it has been disseminated.

Support science education!

You are correct not to take the information given to you from second hand sources at face value (have we not all learned that lesson yet?.) However, when you say you have looked into it and you still seem to let your preconceptions blind you to the possible, you do yourself, your niece and your niece's memory a disservice

Your pain is palatable, even through this cold communication device, I wish you well.
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arikara Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 11:58 PM
Response to Reply #86
115. Welcome to DU
Your compassion is greatly appreciated, there are a lot of hurt people on this thread including yours truly. However, I shame myself when I give a snarky knee jerk response to someone else who's so obviously in pain. So thank you for your response.

I posted Dr Foster's link hoping that someone would find some value to learning that there have been studies done on the prevention side of things. I know this man isn't a charlatan, he spends his own time and money successfully helping aids patients in Africa. He self publishes and any profit above the publishing costs go to fund the aids work in Africa, and he gives his books away online because he just wants people to have access to the information. I know people who go to Africa to work with him, and I've had the pleasure of meeting him and listening to him speak about his work. Personally, especially given my family history of dementia I've started taking the supplements that he recommends. Its cheap and already my immune system is much better, I don't get sick with every cold and flu that I come in contact with anymore.

Peace and best wishes to you Sam Ervin jret

:hi:

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Odin2005 Donating Member (1000+ posts) Send PM | Profile | Ignore Mon Aug-27-07 08:31 AM
Response to Reply #57
120. Quack, quack, quack...
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Sam Ervin jret Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 05:40 PM
Response to Reply #19
79. goggle scholar it! The basic info is not new, only the patent for the lipoprotein "hoped for cure".
The research into the basic idea that alzheimer's is not just a Neuro disease but rather a neurovascular disease is a growing and important area of research in the search for treatment for such problems as glaucoma and dementia. The plaque that develops on your blood vessels obviously is in the blood vessels in the brain too. It is believed that this is the end result of a line of reactions that start with differing iron, calcium and other free radicals in the blood stream. To put it another way a chain reaction starting with a simple molecular imbalance in your brain leads to junk clotting your brain or rather, your blood in your brain. No oxygen. No life. Eat your green vegetables. Eat plenty of fresh fish. Eat little meat. Take a daily vitamin. Do not smoke. A glass of red wine (1) if you have no history of family trouble. And a heap of common sense
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Digit Donating Member (1000+ posts) Send PM | Profile | Ignore Sat Aug-25-07 09:46 PM
Response to Original message
20. My cousin was diagnosed by the Mayo clinic 3 yrs ago...she is now only 53.
She has deteriorated alot in the past 3 years, and they have no health insurance.
Oh, she WAS working a full-time job as a physicians asst until she began losing her memory, and then they fired her.
I hope they find something to reverse this horrible disease.
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cboy4 Donating Member (1000+ posts) Send PM | Profile | Ignore Sat Aug-25-07 09:56 PM
Response to Original message
22. Yea, cancer is horrific, but IMO, there are few diseases as cruel
as Alzheimers.

I pray, pray that this is it.
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dweller Donating Member (1000+ posts) Send PM | Profile | Ignore Sat Aug-25-07 09:58 PM
Response to Original message
23. hmm, a search on amyloids revealed this
Edited on Sat Aug-25-07 10:14 PM by dweller
http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=pubmed&dopt=AbstractPlus&list_uids=17140265
A molecular link between the active component of marijuana and Alzheimer's disease pathology.

i bet we're not going to be hearing much more on that research...

dp
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IndyOp Donating Member (1000+ posts) Send PM | Profile | Ignore Sat Aug-25-07 10:14 PM
Response to Reply #23
26. Wow - smoking pot could slow the progression of Alzheimers.
THC competitively inhibits the enzyme acetylcholinesterase (AChE) as well as prevents AChE-induced amyloid beta-peptide (Abeta) aggregation, the key pathological marker of Alzheimer's disease. <snip> Compared to currently approved drugs prescribed for the treatment of Alzheimer's disease, THC is a considerably superior inhibitor of Abeta aggregation, and this study provides a previously unrecognized molecular mechanism through which cannabinoid molecules may directly impact the progression of this debilitating disease.
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dweller Donating Member (1000+ posts) Send PM | Profile | Ignore Sat Aug-25-07 10:19 PM
Response to Reply #26
27. yes, that is what it states
Edited on Sat Aug-25-07 10:27 PM by dweller
and that study is about a year old.

have you ever heard of any research concerning THC and Alzheimer's ?

neither have i,
dp
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IndyOp Donating Member (1000+ posts) Send PM | Profile | Ignore Sat Aug-25-07 10:28 PM
Response to Reply #27
31. I've seen only research on nicotine and Alzheimer's in past...
Alzheimer’s disease is characterized by degeneration of various structures in the brain, with development of amyloid plaques and neurofibrillary tangles. But deficiencies in the neurotransmitter acetylcholine also occur, and acetylcholine is known to be crucial for attention, learning, and memory—areas where patients with Alzheimer’s have serious problems. In fact, the only two drugs currently available to help such patients are associated with modest improvements in cognitive function block the breakdown of acetylcholine in the brain.

Now enter nicotine. In the brain, some of the nerve receptors that control the release of acetylcholine are stimulated by nicotine. They are called nicotinic cholinergic receptors. A good 50 percent of these receptors are known to be lost in the brains of patients with Alzheimer’s, but that putatively leaves some 50 percent. Thus investigators reckoned that if nicotine, or a nicotinelike compound, was given as a drug to a patient with Alzheimer’s, it might act on the intact nicotinic cholinergic receptors in the brain, step up the release of acetylcholine, and in turn boost attention, learning, and memory.

Evidence suggests that such reasoning has some merit. For example, Paul Newhouse, M.D., a psychiatrist with the University of Vermont College of Medicine in Burlington, and his colleagues first showed, in human subjects, that nicotinic cholinergic receptors are important for learning and memory. More recently they have found, in seven patients with Alzheimer’s, that a novel nicotinelike compound called ABT-418, made by Abbott Laboratories, can improve learning and memory significantly, at least over the short term.

http://www.psych.org/pnews/00-03-17/nicotine.html
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Mythsaje Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 05:08 AM
Response to Reply #27
39. I have...
Edited on Sun Aug-26-07 05:08 AM by Mythsaje
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Sam Ervin jret Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 08:05 PM
Response to Reply #26
98. This would make sense because glaucoma is treated with pot and Alzheimer's is a plague on brain tiss...
and glaucoma ( one form ) is a plaque on the tissue of the optical nerve also connected to the brain, some believe just an extension of brain tissue. Many forms of Alzheimer/Glaucoma research are overlapping. As are many areas in science these days.?
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mentalsolstice Donating Member (1000+ posts) Send PM | Profile | Ignore Sat Aug-25-07 10:06 PM
Response to Original message
25. Such an ugly disease
It runs through my husband's family, on his father's side. Fortunately, most of my immediate family have suffered with weak bodies, but strong minds. My husband is 60, and every time he can't recall a word, concept or name, I get panicky.
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cutlassmama Donating Member (1000+ posts) Send PM | Profile | Ignore Sat Aug-25-07 10:23 PM
Response to Original message
29. I have three relatives with it, or have died from it. Thanks for posting!
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WillyT Donating Member (1000+ posts) Send PM | Profile | Ignore Sat Aug-25-07 10:27 PM
Response to Original message
30. Hooray For Some GOOD News !!!
How refreshing!

:kick:
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IndyOp Donating Member (1000+ posts) Send PM | Profile | Ignore Sat Aug-25-07 10:29 PM
Response to Reply #30
32. Refreshing in more than one way, ha?


:hi:
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WillyT Donating Member (1000+ posts) Send PM | Profile | Ignore Sat Aug-25-07 11:11 PM
Response to Reply #32
33. Yes !!!
:hi:
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NoodleyAppendage Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 12:03 AM
Response to Original message
35. Yet ANOTHER "science by PR" bombastic and WRONG headline.
They haven't found the "cure" and can't make the claim before its even tested in humans! Hello...

The last big "cure" for AD, an amyloid-related vaccine, resulted in the deaths of numerous trial participants and the research was halted for years (recently resumed).

BEWARE any PR-related release meant to pump up the status of scientists and institutions over the FACTS as they currently stand.

J
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LeftishBrit Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 03:14 AM
Response to Reply #35
38. This is not PR for the scientists, but sales for the newspaper
Scientists would not usually claim a 'cure' so irresponsibly, as this would be against professional codes of ethics and get them into trouble, as well as just making them look stupid to their peers.

However, our tabloid newspapers don't have the same codes of ethics, and will say almost anything that will sell. So they generally sensationalize everything that they come across. Never trust anything in the 'Daily Express', 'Daily Mail', or 'Sun'.

Yes, you're right that it's certainly not a 'cure' when still in the mouse-research stage. A lot more work will need to be done.

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Coexist Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 07:36 PM
Response to Reply #35
96. damn that was a buzzkill
I was all excited and then took the time to really read through the thread.
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LeftishBrit Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 03:09 AM
Response to Original message
37. It's promising but still some way off a cure
The 'Daily Express' is not one of our more reliable papers, and is inclined to sensationalize things. This *may* lead to a cure, but a lot of further research and then clinical trials will be necessary. Still, it's very encouraging news!
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TZ Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 06:10 AM
Response to Original message
40. This article is an oversimplification
This is a better explanation of what they are talking about:
Vaccine Thwarts The Tangles Of Alzheimer's
Science Daily — A new study by NYU Medical Center researchers shows for the first time that the immune system can combat the pathological form of tau protein, a key protein implicated in Alzheimer's disease. The researchers, led by Einar Sigurdsson Ph.D., Assistant Professor of Psychiatry and Pathology at New York University School of Medicine, created a vaccine in mice that suppresses aggregates of tau. The protein accumulates into harmful tangles in the memory center of the brains of Alzheimer's patients.


The vaccine successfully slowed the deterioration of motor abilities produced by excessive amounts of tau in the central nervous system of mice, according to the study published in the August 22, 2007 issue of the Journal of Neuroscience. Dr. Sigurdsson plans to conduct follow-up studies using mice that slowly develop tangles and cognitive impairments without movement problems.

http://www.sciencedaily.com/releases/2007/08/070821181029.htm
So we are still aways from actually treating anybody with this "vaccine" but it is a promising lead
And for all those people who want to push the total bullshit that Big Pharma isn't interested in cures..How about preventatives for sickness (ie HPV vaccine PREVENTS cancer) and its possible this could develop into a preventative treatment as well.
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intaglio Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 09:02 AM
Response to Original message
41. I would hang fire on this until the publication in "Nature"
although the University of Rochester is well respected. The lead researcher appears to be marketing through the company "Socratech" (an affiliate of UR) and the other seems to have some unusual ways of drawing parallels. I do not say they are mislead just to hang fire.
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laylah Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 10:40 AM
Response to Original message
43. Unfortunately,
as with cancer cures since the '40's, big Pharma will not let this happen. Too much $$$ to be lost. F*ckers.
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LeftishBrit Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 12:04 PM
Response to Reply #43
46. Then how come...
does 'Pharma' provide antibiotics to *cure* diseases? Why are survival rates for cancer twice what they were 30 years ago? Why do about two-thirds of women with breast cancer live for 20 years nowadays, as compared with less than half up to 15 years ago? Why do most children with leukemia recover nowadays, when in the 40s all died?

And it's not as though 'Pharma' are generally making fantastic amounts from Alzheimers disease nowadays. There are a limited number of drugs that can delay progression, over a limited amount of time. 'Pharma' would probably make more money if it did have a cure for the condition.

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SidDithers Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 01:37 PM
Response to Reply #46
58. Don't expect an answer...
some people are just too wrapped in the idea of evil big Pharma. It's amazing the crap that they believe in their paranoid fantasy world.

Sid
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entanglement Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 06:46 PM
Response to Reply #58
88. Conspiracy theories aside, Big Pharma has certainly committed its share of misdeeds
At the root cause is the profit motive. Take the example of Peptic ulcers. Two scientists had an uphill battle proving that peptic ulcers were caused by helicobacter pylorii . Glaxo- SmithKline & Astra were making $8 billion peddling symptomatic relief and vehemently opposed the independent work of Dr Barry Marshall and Dr Robin Warren. They were vindicated eventually (and won the 2005 Nobel Prize in Physiology or Medicine) but it took them many years. Millions of people who've been cured of peptic ulcer should certainly thank these two for not giving in to big pharma.
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SidDithers Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 06:53 PM
Response to Reply #88
90. Certainly, the pharma companies 're not all candy and flowers...
but really, the "cancer cure in the 40's" belief is one that is just indefensible.

Sid
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entanglement Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 07:03 PM
Response to Reply #90
94. I agree
If anything, conspiracy theories of that ilk only hurt efforts to reform health care.

:)
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laylah Donating Member (1000+ posts) Send PM | Profile | Ignore Mon Aug-27-07 04:02 PM
Response to Reply #58
130. Hey SidDithers...
Edited on Mon Aug-27-07 04:09 PM by laylah
there will be a response. I watched my dad waste away with cancer, I have read and researched. There HAVE been cures for certain cancers since the '40's that Big Pharma HAVE aided in keeping under wraps. Don't you dare assume to know me! My paranoid fantasy world my happy hiney! What a jerk.

edited to add: http://www.healthy-option.com/rife_article_2.html
http://lists.topica.com/lists/TheOtherNews/read/message.html?sort=d&mid=1716124483
http://www.rense.com/health/rife_new.htm
http://www.xenophilia.com/zb0012b.htm
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SidDithers Donating Member (1000+ posts) Send PM | Profile | Ignore Mon Aug-27-07 04:05 PM
Response to Reply #130
131. Oh. I wait with baited breath...nt
Sid
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zyguh Donating Member (63 posts) Send PM | Profile | Ignore Sun Aug-26-07 02:26 PM
Response to Reply #46
62. Google Royal Raymond Rife and you will see why......
Google Royal Raymond Rife and read the entire story of his work, research, and life and you will see why people are so paranoid of the Big Pharma companies, and the American Medical Association in general.

In the 1950's, as reported in front page headlines around the country, there WAS a cure for cancer. It was based on the work of Rife. In short, he took a mechanical approach to curing disease, instead of a chemical approach. He built a microscope that was as powerful as the electron microscopes but with his microscope you didn't have to kill the sample with the dyes to see it....he could see individual cancer cells with his microscope and that allowed him to work with his other device and fine tune the frequency until he could watch the cancer cell explode when he found the right frequency to play at it.

The Rife machine basically was based on the idea that just like playing the correct frequency at a glass could cause the glass to shatter, playing the right frequency at an individual cell should cause that cell to shatter or explode as well. And since his microscope was better than the RCA electron microscopes he could watch the cells as he tuned the "dials" and would see the cancer cell explode when he hit the correct frequency. And it worked, and he went on to find the correct frequency to destroy almost every single disease known to man at the time. Thats right, using one simple machine, that anyone could turn on and use, Rife could cure almost anything. All you had to do was turn the machine on, set it to the correct frequency that Rife had already discovered, and let it run for awhile, doing daily treatments until you were cured. No fuss, no hassle, cheap and simple, and most importantly something you could do right in your own home without the need for a doctor. Sure, the doctors would be needed to find out what you had to begin with, but once you knew you could treat it yourself without having to waste anymore money at the hospital.

And the AMA announced that cancer had been cured, and it made headlines everywhere.

AND........no ones quite sure why what happened next happened but Rife was denounced, was arrested and jailed, and his research and life were systematically destroyed. The electron microscope went on to make billions (instead of Rife's better microscope), and the entire medical establishment was assured that instead of being relegated to the role of "tell the patient what they have so they can go home and treat it themselves" doctors and hospitals were guaranteed to be the only ones to treat and "cure" patients, and the Pharma companies were able to turn the treatment of cancer into a billion dollar industry. The treatment of cancer with drugs instead of the inexpensive CURE of cancer with a machine......

Really, google it, and read everything you can about Rife and his work and what happened and see if you dont get pissed off too
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SidDithers Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 03:58 PM
Response to Reply #62
69. I usually check quackwatch first...
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KittyWampus Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 04:15 PM
Response to Reply #69
73. Ah, quackwatch, the modern day version of the catholic church denouncing Galileo
either you accept the Scientific Industrial Complex's orthodoxy or get swiftboated.



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SidDithers Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 05:35 PM
Response to Reply #73
77. Ah, woo-woo's...
Edited on Sun Aug-26-07 05:37 PM by SidDithers
either you believe the crap they're peddling, or you get accused of being part of a "scientific industrial complex". Which, of course, amply illustrates just how little they actually know about science.

Sid

Edit: but a prime example of #27 of the WWC.
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KittyWampus Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 05:43 PM
Response to Reply #77
80. the arrogance of "how little they actually know about science" speaks volumes
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Posteritatis Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 05:59 PM
Response to Reply #80
83. ...of truth... (nt)
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SidDithers Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 06:50 PM
Response to Reply #80
89. It's arrogance to think that you...
and the rest of the google keyboard scientists know better than the real ones.

Sid
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HiFructosePronSyrup Donating Member (1000+ posts) Send PM | Profile | Ignore Mon Aug-27-07 11:56 AM
Response to Reply #73
127. Did Galileo have a magical cancer explodin' microscope?
:eyes:
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bonito Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 08:02 PM
Response to Reply #69
97. Quackwatch oh boy
My experience tells me its full of shit.
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SidDithers Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 08:19 PM
Response to Reply #97
100. Got a better site?...
Edited on Sun Aug-26-07 08:21 PM by SidDithers
strangely, I can't find anything about Rife at any respectable site on the web. Now, the fact that rense comes up as the first link should tell you something.

Sid

Edit: National Council Against Health Care Fraud any better?
http://www.ncahf.org/articles/o-r/rife.html
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Posteritatis Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 08:58 PM
Response to Reply #100
104. Away with your facts and reality! They inconvenience the woo! (nt)
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bonito Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 09:12 PM
Response to Reply #100
106. Experience is the best teacher
I've found that site to be very misleading by experience, if I had believed info there, my wife would have died some time ago.
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SidDithers Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 09:21 PM
Response to Reply #106
108. Perhaps you shouldn't rely on the internet...
when making life and death decisions.

Sid
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bonito Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 09:38 PM
Response to Reply #108
110. I here ya, but that is exactly what saved us
I'll pm you with my phone# if your interested I can tell you more.
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Posteritatis Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 04:18 PM
Response to Reply #62
74. I'm pissed off, but mainly at Rife. I hate pseudoscientific quacks. (nt)
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Posteritatis Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 04:14 PM
Response to Reply #43
72. That explains all those times I've died of smallpox lately. ...Oh, wait. (nt)
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lonestarnot Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 11:56 AM
Response to Original message
44. Ta-da.
Yeah. :applause: Everything is prollee "blindly simple," but we would rather they be complicated.
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windoe Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 12:04 PM
Response to Original message
45. Oh if this actually works....
It sounds like the tests have only been done on animals. My mother and her sister have Altzheimer's and I wish this treatment were made available sooner than 2 years. I am going to research amyloid and ask their doctors if we can try it safely. Thank you for posting this, if it works this will change many lives for the better!
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wryter2000 Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 12:09 PM
Response to Original message
47. OMG!
If you've ever known anyone who has to cope with this disease, you know it's about the worst thing that can happen to someone. If there is a God, please let this be true!
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pitohui Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 01:20 PM
Response to Original message
53. oh in mice :-(
i hope for a change they're right but i've had so many false alarms that i'm going to want to see the human trials and successes before i get excited

good luck to these researchers tho
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BornagainDUer Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 02:14 PM
Response to Original message
60. Chelation therapy works wonders but the AMA and Big Pharma doesn't like it
because it competes with their drug profiteering.
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bonito Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 09:15 PM
Response to Reply #60
107. I hear you
:thumbsup:
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BornagainDUer Donating Member (1000+ posts) Send PM | Profile | Ignore Mon Aug-27-07 03:56 PM
Response to Reply #107
129. I had chelation for heavy metal contamination I got in the military. It
also cleans cholesterol throughout your entire circulatory system. While getting treatement I was shooting the breeze with a guy who was 102 years old sitting next to me. He was born in 1898 and was happy that he lived to see three centuries.
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Autumn Colors Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 02:23 PM
Response to Original message
61. Too late for my grandmother
Hopefully soon enough to protect her children and grandchildren.
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Totally Committed Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 02:32 PM
Response to Original message
63. It runs on my mother's side of the family.
What worries me about this article is it's in the "Showbiz" section. But, I am keeping my fingers crossed bigtime!

Thanks so much for posting this.

TC
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PetrusMonsFormicarum Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 02:33 PM
Response to Original message
64. The Mad Cow Link
Isn't it interesting that both amyloid plaques in the brain and the killing mechanism behind Mad Cow disease (Kreutzfeld-Jacob in humans) are both pre-biotic proteins, mindless villains that have bedeviled life since the beginnings. Here we are, the pinnacle of evolution, and we are brought down by an ancient enemy we can't even get mad at--it's not alive!
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bamacrat Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 02:34 PM
Response to Original message
65. That's great but sadly it will probably be so expensive no one could afford it.
In America at least.
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THUNDER HANDS Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 02:38 PM
Response to Original message
66. so does this reverse the affects of the disease
or just stop or slow it's progression?

My girlfriend's mom has alzheimers, and she was only 48 when first diagnosed with it.
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eleny Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 04:54 PM
Response to Reply #66
76. Here's a quote about that from the article
"“We think that if we intervene early in human patients with this treatment we can clear the amyloid away preventing damaging and reverse some of the damage that has already taken place. But we need to get the treatment into patients while the amyloid is still soft and before it has had a chance to harden"
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entanglement Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 06:54 PM
Response to Original message
91. If I had a dime for every drug that cured disease in mice and failed to make it to FDA approval...
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Posteritatis Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 09:00 PM
Response to Reply #91
105. What's the normal timeframe between those two points?
I'm curious as to how much stuff is in between those stages these days.
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entanglement Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 10:05 PM
Response to Reply #105
113. 7 to 10 years, when you include clinical trials (Phase I,II, III) and the approval process
There might be exceptions, though.
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Posteritatis Donating Member (1000+ posts) Send PM | Profile | Ignore Mon Aug-27-07 02:59 AM
Response to Reply #113
116. Might that be why so many of them are in the news and not approved yet?
I've been seeing more and more reports of potential medical discoveries such as this one in the past few years. I'm not sure if it's because there's more being made, because there's more being reported, or because I'm paying more attention. I know the third's happening, I suspect the second is, and I'm clueless on the first.

Is it possible that there's a big pile of these currently a few years into that process, or do most of the ones that get to this phase actually wind up not working through the clinical trials?
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entanglement Donating Member (1000+ posts) Send PM | Profile | Ignore Mon Aug-27-07 03:38 AM
Response to Reply #116
117. Only 1 in 1000 molecules even makes it to clinical testing
1 in 5 of those that enter the clinical stage (i.e. testing on humans) is approved by the FDA.
Of course, the volume of drug research itself has increased - no doubt of that. In the last 20 years major breakthroughs in biochemistry, molecular biology and genetics have occurred. Understanding the mechanics of say cancer or HIV at the cellular level is leading to whole new classes of drugs - like protease inhibitors for AIDS or angiogenesis inhibitors for cancer. So there's a reason for increased news coverage - but they could certainly use less sensational / misleading headlines.
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Posteritatis Donating Member (1000+ posts) Send PM | Profile | Ignore Mon Aug-27-07 11:47 AM
Response to Reply #117
122. Wow, I didn't know it was that few
Thanks for the info!
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Coexist Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 07:33 PM
Response to Original message
95. never mind...
Edited on Sun Aug-26-07 07:38 PM by FLDem5
I read through the entire thread and got way too excited too soon.
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Sam Ervin jret Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 08:11 PM
Response to Reply #95
99. lol .....too soon to tell.
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whoneedstickets Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 08:22 PM
Response to Original message
101. ...but then they forgot all about it...
ok, I know its not funny. My grandmother has it.
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provis99 Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-26-07 08:33 PM
Response to Original message
103. I note that its not drug company scientists who are touting this
Drug company employees have never found a cure for anything. Curing something chronic would not benefit a drug company's profits. All research aiming to cure a chronic disease originates from government researchers or academia, who aren't motivated by profit.
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spindoctor Donating Member (1000+ posts) Send PM | Profile | Ignore Mon Aug-27-07 05:13 AM
Response to Original message
119. Smoking prevents Alzheimers n/t
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Posteritatis Donating Member (1000+ posts) Send PM | Profile | Ignore Mon Aug-27-07 11:47 AM
Response to Reply #119
123. The reverse is eventually true, but that doesn't make either a good thing.. (nt)
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HiFructosePronSyrup Donating Member (1000+ posts) Send PM | Profile | Ignore Mon Aug-27-07 11:50 AM
Response to Original message
124. Those stupid scientists.
Don't they know that magical crystal therapy will cure Alzheimers but the Pharma companies are in league with the Masons and the Rothschilds to prevent people from knowing about it?
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