Cochrane Review: Adverse events after immunisation with aluminium-containing DTP vaccines

[HuckleB]

http://www.sciencedirect.com/science/article/B6W8X-4BJVHRS-N/2/de3c17a2f0fa9e7edde2dd5286371560

"We have reviewed evidence of adverse events after exposure to aluminium-containing vaccines against diphtheria, tetanus, and pertussis (DTP), alone or in combination, compared with identical vaccines, either without aluminium or containing aluminium in different concentrations. The study is a systematic review with meta-analysis. We searched the Cochrane Vaccines Field Register, the Cochrane Library, Medline, Embase, Biological Abstracts, Science Citation Index, and the Vaccine Adverse Event Reporting System website for relevant studies. Reference lists of retrieved articles were scanned for further studies. We included randomised and semi-randomised trials and comparative cohort studies if the report gave sufficient information for us to extract aluminium concentration, vaccine composition, and safety outcomes. Two reviewers extracted data in a standard way from all included studies and assessed the methodological quality of the studies. We identified 35 reports of studies and included three randomised trials, four semi-randomised trials, and one cohort study. We did a meta-analysis of data from five studies around two main comparisons (vaccines containing aluminium hydroxide vs no adjuvant in children aged up to 18 months and vaccines containing different types of aluminium vs no adjuvants in children aged 10–16 years). In young children, vaccines with aluminium hydroxide caused significantly more erythema and induration than plain vaccines (odds ratio 1·87 <95% Cl 1·57–2·24>) and significantly fewer reactions of all types (0·21 <0·15–0·28>). The frequencies of local reactions of all types, collapse or convulsions, and persistent crying or screaming did not differ between the two cohorts of the trials. In older children, there was no association between exposure to aluminium-containing vaccines and onset of (local) induration, swelling, or a raised temperature, but there was an association with local pain lasting up to 14 days (2·05 <1·25–3·38>). We found no evidence that aluminium salts in vaccines cause any serious or long-lasting adverse events. Despite a lack of good-quality evidence we do not recommend that any further research on this topic is undertaken."

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For more information:

Aluminum Adjuvants in Vaccines -- A Very Fair Review
http://www.immunizationinfo.org/issues/vaccine-components/aluminum-adjuvants-vaccines


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Finally, for good measure, here is the full paper (a summary was linked in another OP) of a study that claims to show motor deficits and motor neuron degeneration as a result of aluminum adjuvant use:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819810/?tool=pubmed

This will allow everyone to look at the study in depth, while also perusing the critiques of the study in the discussion at this piece:

http://scienceblogs.com/insolence/2010/05/a_confluence_of_the_anti-vaccine_and_hea.php

ScienceMom and Archangl508 bring up some very big concerns that do appear justified when one looks at the study as I've linked to it. It is no wonder that this study earned no big accolades.


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It appears that the evidence that is supposed to be scaring us all away from vaccines, via yet another monster (this time aluminum) is not all that.

I'm going skiing. See ya'll in a few weeks.

:toast:

[kestrel91316]

1. Aluminum adjuvants are felt to be problematic in cats, having been implicated in

the development of vaccine-associated sarcomas, but that's cats for you. They are a whole different creature from anything else, and chronic inflammation is their strong suit.

[pnwmom]

3. Many people are susceptible to inflammatory diseases,

and those people might be affected in a similar way as are cats.

As of course you know, the reason we study new drugs using animals is because problems in other animals can be predictive of problems in humans, so I think those cat studies should be taken seriously. Thank you for mentioning them.

I thought it was interesting when I brought my dog in for his vaccination and found out that the recommended vaccination schedule for dogs has been reduced over the years -- instead of added to, as with childhood vaccinations. My vet said that was because of concerns about auto-immune problems caused by vaccines. I wonder how long it will be before doctors of humans learn what doctors of other animals already know.

[mzmolly]

16. Dogs were the first beneficiary of mercury vaccine removal as well IIRC?

Are vets better at advocating for safety than pediatricians?

[mzmolly]

15. Good grief.

:wow:

[Name removed]

2. Deleted message

Message removed by moderator. Click here to review the message board rules.

[pnwmom]

5. Do you think those British Columbia medical researchers are anti-vaxers?

Or were they researchers who were studying the safety of a particular vaccine adjuvant?

[Warpy]

6. Did you read the article?

Try it sometime.

[pnwmom]

8. Did you read my question?

It doesn't appear that you did.

[pnwmom]

4. Why should concerns about the safety of a particular non-essential adjuvant

scare anyone away from all vaccines?

[HuckleB]

19. Keep spinning and moving those goalposts!

:rofl:

[mhatrw]

7. Despite a lack of good-quality evidence ...

"Despite a lack of good-quality evidence we do not recommend that any further research on this topic is undertaken."

Let that statement roll around in your head awhile.

"Despite a lack of good-quality evidence we do not recommend that any further research on this topic is undertaken."

Does that sound like good science to you? Recommending no further study despite a lack of good-quality evidence?

What the fuck kind of recommendation is that? Are they afraid of what they might find if they did some basic toxicological research?

http://www.ncbi.nlm.nih.gov/pubmed/19740540

Gulf War Syndrome is a multi-system disorder afflicting many veterans of Western armies in the 1990-1991 Gulf War. A number of those afflicted may show neurological deficits including various cognitive dysfunctions and motor neuron disease, the latter expression virtually indistinguishable from classical amyotrophic lateral sclerosis (ALS) except for the age of onset. This ALS "cluster" represents the second such ALS cluster described in the literature to date. Possible causes of GWS include several of the adjuvants in the anthrax vaccine and others. The most likely culprit appears to be aluminum hydroxide. In an initial series of experiments, we examined the potential toxicity of aluminum hydroxide in male, outbred CD-1 mice injected subcutaneously in two equivalent-to-human doses. After sacrifice, spinal cord and motor cortex samples were examined by immunohistochemistry. Aluminum-treated mice showed significantly increased apoptosis of motor neurons and increases in reactive astrocytes and microglial proliferation within the spinal cord and cortex. Morin stain detected the presence of aluminum in the cytoplasm of motor neurons with some neurons also testing positive for the presence of hyper-phosphorylated tau protein, a pathological hallmark of various neurological diseases, including Alzheimer's disease and frontotemporal dementia. A second series of experiments was conducted on mice injected with six doses of aluminum hydroxide. Behavioural analyses in these mice revealed significant impairments in a number of motor functions as well as diminished spatial memory capacity. The demonstrated neurotoxicity of aluminum hydroxide and its relative ubiquity as an adjuvant suggest that greater scrutiny by the scientific community is warranted.

"Despite a lack of good-quality evidence we do not recommend that any further research on this topic is undertaken."

Un-fucking-believable

"Despite a lack of good-quality evidence we do not recommend that any further research on this topic is undertaken."

That about sums up the entire Pharmy Army.

[semillama]

9. Um, that doesn't mean what you want it to mean

The lack of good-quality evidence is for the supposed aluminum-adverse effect link. There's no good evidence, so therefore no further work is warranted.

But then, you'll believe what you want to believe anyway.

[trotsky]

10. Shhhh

Facts are not welcome in the anti-vax agenda.

[mhatrw]

12. Facts such as "Despite" means "Because"?

Priceless. You will agree with anything that promotes your agenda.

[trotsky]

13. My agenda is one of facts.

I embrace the facts.

Anti-vaxers deny and flee from them.

[Name removed]

11. Deleted message

Message removed by moderator. Click here to review the message board rules.

[mhatrw]

14. You might want to look up the meaning of the word "despite".

Thanks!

[mzmolly]

17. Ever get tired of hearing that words have a completely different meaning

when we're discussing vaccination?

"You don't understand ..." is the go to response, it seems.

[HuckleB]

18. As usual, you fail to understand anything.

:eyes: