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Attacking Cancer's Sweet Tooth Is Effective Strategy Against Tumors

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Mr. McD Donating Member (1000+ posts) Send PM | Profile | Ignore Tue Jul-18-06 11:34 AM
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Attacking Cancer's Sweet Tooth Is Effective Strategy Against Tumors
As a tumor grows, cells crowd one another and may be cut off from oxygen-carrying blood vessels--a distinct disadvantage since most cells require oxygen to produce the bulk of their energy-storing adenosine triphosphate (ATP). In the 1920s, Otto Warburg proposed that some cancer cells evolved the ability to switch over to an ancient, oxygen-free route, the glycolytic pathway. What is more, they continue to use this pathway even when access to oxygen is restored. Though the so-called Warburg effect has since been confirmed, the role-played by glycolysis in cancer has been largely ignored. Few have attempted to attack specific points along the glycolytic pathway to gain a therapeutic effect.

http://www.sciencedaily.com/releases/2006/06/0606300949...

Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance
Cancer Cell, Volume 9, Issue 6, 13 June 2006, Pages 425-434

http://www.sciencedirect.com/science?_ob=ArticleURL&_ud...

http://www.sciencedirect.com/science?_ob=MImg&_imagekey...

Otto Warburg, a German physician was awarded a Nobel Prize over 75 years ago for first uncovering cancer cells' massive dependence on sugar as a fuel source.

http://www.newmediaexplorer.org/chris/2004/02/03/otto_w...

Dietary Glycemic Load and Risk of Colorectal Cancer in the Women's Health Study
Journal of the National Cancer Institute, Vol. 96, No. 3, 229-233, February 4, 2004

http://jncicancerspectrum.oxfordjournals.org/cgi/conten...




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