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HysteryDiagnosis Donating Member (1000+ posts) Send PM | Profile | Ignore Thu Sep-17-09 06:58 PM
Original message
Pulmonary Hypertension
Please notice the "which may" at the bottom of this paper. It's very hard indeed for the ignored to acknowledge that naturally occurring substances could have effects such as these.

http://www.ncbi.nlm.nih.gov/pubmed/19597040?ordinalpos=...
1: Hypertension. 2009 Sep;54(3):668-75. Epub 2009 Jul 13.Click here to read Links

Comment in:
Hypertension. 2009 Sep;54(3):473-4.

Resveratrol prevents monocrotaline-induced pulmonary hypertension in rats.
Csiszar A, Labinskyy N, Olson S, Pinto JT, Gupte S, Wu JM, Hu F, Ballabh P, Podlutsky A, Losonczy G, de Cabo R, Mathew R, Wolin MS, Ungvari Z.

Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA.

Proliferation of pulmonary arterial smooth muscle cells, endothelial dysfunction, oxidative stress, and inflammation promotes the development of pulmonary hypertension. Resveratrol is a polyphenolic compound that exerts antioxidant and anti-inflammatory protective effects in the systemic circulation, but its effects on pulmonary arteries remain poorly defined. The present study was undertaken to investigate the efficacy of resveratrol to prevent pulmonary hypertension. Rats injected with monocrotaline progressively developed pulmonary hypertension. Resveratrol treatment (25 mg/kg per day, PO, from day 1 postmonocrotaline) attenuated right ventricular systolic pressure and pulmonary arterial remodeling, decreased expression of inflammatory cytokines (tumor necrosis factor-alpha, interleukin 1beta, interleukin 6, and platelet-derived growth factor-alpha/beta), and limited leukocyte infiltration in the lung.

Resveratrol also inhibited proliferation of pulmonary arterial smooth muscle cells. Treatment of rats with resveratrol increased expression of endothelial NO synthase, decreased oxidative stress, and improved endothelial function in small pulmonary arteries. Pulmonary hypertension was associated with an upregulation of NAD(P)H oxidase in small pulmonary arteries, which was significantly attenuated by resveratrol treatment. Our studies show that resveratrol exerts anti-inflammatory, antioxidant, and antiproliferative effects in the pulmonary arteries, which may contribute to the prevention of pulmonary hypertension.
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Tangerine LaBamba Donating Member (1000+ posts) Send PM | Profile | Ignore Thu Sep-17-09 07:00 PM
Response to Original message
1. See? I knew it!
I've been saying this all along, but no one believed it because I was wearing my Harvard sweatshirt.

People can be such reverse snobs, I swear.....................
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HysteryDiagnosis Donating Member (1000+ posts) Send PM | Profile | Ignore Thu Sep-17-09 07:01 PM
Response to Reply #1
2. What in the world are you typing about??? n/t
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BoneDaddy Donating Member (1000+ posts) Send PM | Profile | Ignore Thu Sep-17-09 07:03 PM
Response to Reply #2
3. my guess is that he felt the same way
about your post
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HysteryDiagnosis Donating Member (1000+ posts) Send PM | Profile | Ignore Thu Sep-17-09 07:04 PM
Response to Reply #3
4. ... trouble with reading comprehension?
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BoneDaddy Donating Member (1000+ posts) Send PM | Profile | Ignore Thu Sep-17-09 07:06 PM
Response to Reply #4
5. Wow, did you have a bad day?
Edited on Thu Sep-17-09 07:06 PM by BoneDaddy
Or are you just a ornery fool who cuts and pastes from medical journals?

Edit: My guess is you are a first year med student who thinks a little knowledge actually impresses people.
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Tangerine LaBamba Donating Member (1000+ posts) Send PM | Profile | Ignore Thu Sep-17-09 07:08 PM
Response to Reply #4
7. No one here has trouble with reading compre-
hension.

And your expertise with cutting and copying is impressive.

I'm sure you had a point - known only to you - in posting this cut-and-copy job, but I'm also sure you're the only one to whom that meaning has been revealed..............................
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Why Syzygy Donating Member (1000+ posts) Send PM | Profile | Ignore Thu Sep-17-09 07:30 PM
Response to Reply #7
9. Isn't it better to
cut and paste something rather than just post a blind link OR WORSE a link to another DU forum?
I think it is. That's just me.
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Tangerine LaBamba Donating Member (1000+ posts) Send PM | Profile | Ignore Thu Sep-17-09 07:52 PM
Response to Reply #9
11. Oh, that crap -
posting the link with some sort of cryptic Subject Line, or, as you note, a link to another DU forum is as annoying as the people who post stuff that means something only to them - i.e., "I just saw my reflection in the bathroom mirror, and, boy, am I gorgeous!"

No matter what the set-up, when something bizarre is posted without explanation, it demands response.

That's just me................. :)
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Why Syzygy Donating Member (1000+ posts) Send PM | Profile | Ignore Thu Sep-17-09 07:56 PM
Response to Reply #11
13. I say something nice.
Once. For repeat offenders, I just unrec 'em. ;)
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Tangerine LaBamba Donating Member (1000+ posts) Send PM | Profile | Ignore Thu Sep-17-09 08:17 PM
Response to Reply #13
15. THAT's what Unrec is for!!!
It never occurred to me.

Thank you. That's EXACTLY right, and I never even thought of it.

Thank you!
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Why Syzygy Donating Member (1000+ posts) Send PM | Profile | Ignore Thu Sep-17-09 09:11 PM
Response to Reply #15
17. Remember Canada!
:hi: I'm packing my Maple Leafs.
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Tangerine LaBamba Donating Member (1000+ posts) Send PM | Profile | Ignore Thu Sep-17-09 07:06 PM
Response to Reply #3
6. Took the words
right out of my ...... uh .............. off my keyboard.

Thank you................
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Why Syzygy Donating Member (1000+ posts) Send PM | Profile | Ignore Thu Sep-17-09 07:28 PM
Response to Reply #3
8. No. I think TL is a wine drinker. nt
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Tangerine LaBamba Donating Member (1000+ posts) Send PM | Profile | Ignore Thu Sep-17-09 07:52 PM
Response to Reply #8
12. Actually,
TL doesn't drink...........
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Why Syzygy Donating Member (1000+ posts) Send PM | Profile | Ignore Thu Sep-17-09 07:58 PM
Response to Reply #12
14. Neither does Syz.
The Harvard sweat shirt was a red herring! I thought you were referring to Resveratrol being derived from wine.
Oh well.
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Tangerine LaBamba Donating Member (1000+ posts) Send PM | Profile | Ignore Thu Sep-17-09 08:17 PM
Response to Reply #14
16. You're too smart
for your own good, smartiepants................... :hi:
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EmeraldCityGrl Donating Member (1000+ posts) Send PM | Profile | Ignore Thu Sep-17-09 07:48 PM
Response to Original message
10. I have PAH. Thank you for the article.
This disease is a killer and this is very promising research.

:toast:
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HysteryDiagnosis Donating Member (1000+ posts) Send PM | Profile | Ignore Fri Sep-18-09 06:48 PM
Response to Reply #10
18. My op was intentionally cryptic. My intent is to show that perhaps,
just perhaps some naturally occurring substances that BELONG in the human body, when in short supply.... RESULT IN UNRESTRAINED INFLAMMATION, IMMUNE SYSTEM ACTIVITY/IMBALANCE etc. In other words... what is coming out is very positive for all of us.... and resveratrol is cool. Better taken in supplement form... that is if you drive a vehicle or if you need to be cognizant on the job.
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BoneDaddy Donating Member (1000+ posts) Send PM | Profile | Ignore Fri Sep-18-09 07:17 PM
Response to Reply #18
19. Ahhh....the ever captivating, stimulating
cryptic medical study posts... I get it now. This is a pitch for the next Dan Brown movie... how fucking careless of me.... Sorry bro/sis, I TOTALLY get it now...its the Freemasons
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HysteryDiagnosis Donating Member (1000+ posts) Send PM | Profile | Ignore Fri Sep-18-09 07:26 PM
Response to Reply #19
20. Bwahahahahahahaaaaa.... you don't get anything. n/t
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BoneDaddy Donating Member (1000+ posts) Send PM | Profile | Ignore Fri Sep-18-09 07:26 PM
Response to Reply #20
21. Wow some things are lost on others
nice come back
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HysteryDiagnosis Donating Member (1000+ posts) Send PM | Profile | Ignore Fri Sep-18-09 07:50 PM
Response to Reply #21
22. Lost yes... but not forgotten.
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BoneDaddy Donating Member (1000+ posts) Send PM | Profile | Ignore Fri Sep-18-09 09:58 PM
Response to Reply #22
23. what were we talking about?
?
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HysteryDiagnosis Donating Member (1000+ posts) Send PM | Profile | Ignore Sat Sep-19-09 03:16 PM
Response to Reply #23
24. Me and you?? Nuttin honey....
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BoneDaddy Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Sep-20-09 12:30 AM
Response to Reply #24
25. I wasn't talking to you
i meant the other idiot
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HysteryDiagnosis Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Sep-20-09 08:19 AM
Response to Reply #25
27. My bad.... but that makes me the other other idiot. Not good. n/t
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Fire_Medic_Dave Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Sep-20-09 12:54 AM
Response to Original message
26. They treat it with Viagra if I'm not mistaken.
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