Autoimmunity caused by genes that cause Autism and Schizophrenia

[HysteryDiagnosis]

Or how would some put it?? I hear voices therefore I have immunological abnormalities, I react to beta casmorphin, (dairy) and I have inflammation in my brain. Yeah, it's the voices causing my immunological anomalies... heh.





Schizophrenia linked with autoimmune disorders

Clinical Data Inc. has published results demonstrating an association between a gene region associated with inflammation and autoimmune disorders, and schizophrenia.

The study, published in the journal Molecular Psychiatry, compared genetic variants in individuals with schizophrenia to individuals who do not have the disease. Sequencing revealed specific genetic variants in the CSF2RA and IL3RA genes associated with schizophrenia, which are
in a cytokine receptor region. Cytokines are signaling compounds, which allow cells to communicate with each other and are particularly important in immune responses.

ABSTRACT:
Schizophrenia is a strongly heritable disorder, and identification of potential candidate genes has accelerated in recent years. Genomewide scans have identified multiple large linkage regions across the genome, with fine-mapping studies and other investigations of biologically plausible targets demonstrating several promising candidate genes of modest effect. The recent introduction of technological platforms for whole-genome association (WGA) studies can provide an opportunity to rapidly identify novel targets, although no WGA studies have been reported in the psychiatric literature to date. We report results of a case–control WGA study in schizophrenia, examining approx500 000 markers, which revealed a strong effect (P=3.7 times 10-7) of a novel locus (rs4129148) near the CSF2RA (colony stimulating factor, receptor 2 alpha) gene in the pseudoautosomal region. Sequencing of CSF2RA and its neighbor, IL3RA (interleukin 3 receptor alpha) in an independent case–control cohort revealed both common intronic haplotypes and several novel, rare missense variants associated with schizophrenia. The presence of cytokine receptor abnormalities in schizophrenia may help explain prior epidemiologic data relating the risk for this illness to altered rates of autoimmune disorders, prenatal infection and familial leukemia.

Study: http://www.nature.com/mp/journal/vaop/ncurrent/abs/4001983a.html

Beta casomorphins found in the urine of autistic children are linked to the aggravation of the symptoms of Autistic Spectrum Disorders (ASD)

Can the pathophysiology of autism be explained by the nature of the discovered urine peptides?
Reichelt KL, Knivsberg AM. (2003) Nutr Neurosci 6(1):19-28
A1 beta casein peptide BCM7 can cross the blood brain barrier and affect brain regions shown to alter in schizophrenic and autistic patients.

ß-Casomorphin Induces Fos-Like Immunoreactivity in Discrete Brain Regions Relevant to Schizophrenia and Autism
Zhongjie Sun, J. Robert Cade, Melvin J. Fregly, R. Malcolm Privette. University of Florida, USA. Autism, Vol. 3, No. 1, 67-83 (1999)

A gluten and casein free diet improved most behaviours in autistics and reduced symptoms in schizophrenic patients. Reduced levels of BCM-7 (from A1 beta casein) corresponded to improvements in symptoms.

Autism and Schizophrenia: Intestinal Disorders,
Cade R et al. (2000) Nutritional Neuroscience 3: 57-72.
A gluten and casein free diet resulted in a significant reduction of symptoms in autistic children linking gluten and casein consumption in the symptoms associated with autistic spectrum disorders

Reports on dietary intervention in autistic disorders
Knivsber AM, Reichelt KL, Nodland M. (2001). Nutr Neurosci. 4(1):25-37

A randomised, controlled study of dietary intervention in autistic syndromes
Knivsberg AM, Reichelt KL, Hoien T, Nodland M. (2002). Nutr Neurosci. 5(4):251-61

[Ilsa]

1. Thank you so much for this article.

I ahve an autistic son, and have wondered about its possible links to other mental health issues, including schizophrenia, since some of the schiz meds appear to help some autism behaviors.

[Ilsa]

2. Oh yeah, the link in OP gives Page Not Found.

[HysteryDiagnosis]

3. I am going to search for a cd I have with some transcripts from an

autism symposium held in California several years ago. In the meantime you can check this out...

http://www.amazon.com/Fighting-Tony-Mary-Callahan/dp/0671632655/ref=pd_bbs_sr_1?ie=UTF8&s=books&qid=1210289640&sr=8-1
Editorial Reviews
From Publishers Weekly
When Callahan's son Tony was diagnosed as autistic at age two, she struggled to understand the conditionabout which little is knownand worked tirelessly to help him improve. Her story takes us through Tony's early years, which included many bouts of screaming for nine hours at a time, head-banging, staring and generally nonresponsive behavior. This account about raising a difficult handicapped child stands out because of its honesty in discussing often ugly feelings. Callahan and her husband experienced extreme guilt, anger and shame, and for one harrowing moment they contemplated killing the boy. By age five, Tony began leading a normal life, and Callahan, a registered nurse, came to believe that a cerebral allergy to cow's milk may have caused Tony's autistic behavior and may account for autism in others. First serial to Ladies' Home Journal.
Copyright 1987 Reed Business Information, Inc.

From Library Journal
This is a short, sweet account of the author's experiences with her son Tony, who at age two was diagnosed as autistic and by age five was functioning normally. His mother now believes that his bizarre behavior was a result of cerebral allergies, controllable by diet. Callahan describes the unfolding awareness of Tony's abnormalities, his diagnosis and early education, and most importantly the family dynamics involved in coping with such a child. Her marriage was stretched to the breaking point and her daughter became in some ways the savior of Tony and of Callahan herself. With neither bitterness nor a therapeutic axe to grind, Callahan truthfully examines self and family in a sad story with a happy ending. Amy Goffman, Children's Rehabilitation Ctr., Charlottesville, Va.
Copyright 1987 Reed Business Information, Inc.




16 books cite this book:

* A Parent'S Guide To Autism: A Parents Guide To Autism by Charles Hart on 6 pages
* Pervasive Developmental Disorders: Diagnosis, Options, and Answers by Mitzi Waltz on page 93, page 213, and page 275
* Autism Treatment Guide, Third Edition by Elizabeth K Gerlach on page 73, and page 80
* Targeting Autism: What We Know, Don't Know, and Can do to Help Young Children with Autism and Related Disorders by Shirley Cohen on page 35, and Back Matter
* Special Diets for Special Kids by Lisa Lewis in Front Matter, and page 12

[Ilsa]

4. I tried a GFCF diet for my son. We had no success. I spoke to his

doctor about what I had heard about brain inflammation, but I have no idea how that could be treated.

We are starting to move into something new with my son. For the last week, he has come home from school very happy, but hyperactive and hyper-chatty. I don't understand what is causing this new behavior. We are trying to reward more quiet behavior, but it is hard to even get his attention now when he is in this phase. It is like he is almost manic. I've had a hard time settling him down for bed, even after warm baths, full stomach, etc.

[HysteryDiagnosis]

5. Here are the notes taken by a parent.... I hope some of this gives

you some worthwhile ideas, you may want to print this for his doc.


Hi all
Saturday was awesome at the oasis Autism 2000 conference. I have much to share. Some new information was given us at this conference THAT WILL BLOW YOU AWAY. I want to make sure this information is entirely accurate for you, so I am going through my notes. Dr Rimland was great as usual, Wakefield was awesome and funny, Dr Pangborn was very interesting and up my alley, and then their was of course Karen Serrousi, a most articulit mom
on the benefits of GF CF and then finally Dr Bradstreet.

One of the bigger announcements is that they are getting to the point of formulating a wonderful "autism center" here in Portland Oregon (oh yeah!). It will be a "medical center" with all disciplines for autism. COOOOL.

Dr Wakefiled showed slides of damaged guts. He said atypical characteristics of this subtype of autims usually have a regression after normal development (that can even include a few months after birth), Ataxia and gut disturbances, Encephalopathia, Notably Wasted (my ears peaked
when he said that, OH MY GOSH!).

Features of this disturbance are Pain 24 7 (I hear moms say their kids screamed all the time), alternating bowel habits (this is important here, were talking both the runs and the hard stuff), soiling underwear, fastidious eating (oh boy, ding ding ding), reflux, and night time waking. He said lots if not all autistics he looked at had FECAL IMPACTIONS , some the size of baby's heads!!

The onset of symptoms are atopy, ear infections, autoimmune diseaes, and in mom usually A FAILED RUBELLA SEROCONVERSION (this is when they jab mom in the hospital with MMR).

Hyperplasia means gross inflammation of lympoid follicules (don't have breakfast when you see that slide). Pussy, enlarged, yellow or red "lymph like nodules". (all this by the way will be in a NEW REPORT with the AMERICIAN JOURNAL OF GASTEROENTEROLOGY). If you are thinking of getting some tests in this vein, the test is called a QUANTATIVE IMMMUNOHISTOCHEMISTRY from your immunologist (before you do an endoscope). This usually reveals Class 2 antigen expression or a state of immune activation. This usually means CD+3 lymphocyte infiltration. Also the CD8 cells are your viral cells. He said lots of kids with autism have elevated CD8 indicating an ongoing infection. Basically, that means an ANTIBODY IN BLOOD IS BINDING TO THE GUT.

Since this area of the body is the second LARGEST epilethial target, it would make sense that the virus would dig in there. He said in the following tables Most autistic children with this infection have"
Low Cd3+ (63%)
Low Cd4+ 60.5%
Low Cd8 63%
Low B cells 16.3%
Low NK Cells 16.3%

Here is the formula of getting this

1. Age of exposure (the peak is around 2 years old)

2. Intensity of exposure

3. A Cocurrent viral infection (which would explain doctors jabbing kids even when sick)
This all equals ATYPICAL PATTERNS OF EXPOSURE, NOT HERETOFORE ever seen.
This cannot be produced other wise except by vaccines!

**NOW, here is the new news. The facts were laid out, THE INTERACTION
OF MEASLES WITH ANOTHER VIRUS MAY BE A RISK FACTOR FOR IBD. HE SAID, the combinations of MEASLES AND MUMPS IS SUSPECTED HERE, NOT MEASLES AND
CHICKEN POX, OR MEASLES AND HEP B, OR MEASLES AND RUBELLA, IT IS MEASLES AND MUMPS!!

Measules puts out an N-Protein simular to the N proteins on epilethial tissues in the gut, therefore the cells are confused...is it the virus I am attacking or the gut? He lastly states that we are not anti vaccine, rather we are wanting a change in VACCINATION STRATEGY or monovalent vaccines. ( I tend to be a bit more stretched towards no vaccine). What will happen with this disease is after a while the intestinal contents are not being metabolized by the liver which lends to the argument that here comes the opoid peptides, whichbasically helps candida to grow, poisins to remain in the body, and high allergic responses.

DR PANGBORN:
He definately admonishes us to get an amino acid analysis (Which I am doing soon, talked to a guy from Carbon Based Corporation at the conference who cured his kid from epilepsy with targeted amino acids in pharmaceutical grades. He mentioned that fatty acids WILL BE OFF if your status of amino acids are off).

He told about some different subtypes of autism

1. PKU although uncommon because of screening, there are some autistics
with this disorder (that when largely undetected). They usually have elevated phenalalanine (sp?)

2. Histidenemia (they have short auditory memory, not good eye contact). They have not enough enzymes and elevated histadine. DMG and Folic ACID greatly needed

3. Lesch-Nyhan Disordered Metabolism. Usually ADENOSINE is weak in these children.

4. Fragile X, the most genetic origin of autism

5. Rett Syndrome-mostly in girls, devastating in boys. Their mitochondrias are not shaped right, they have great need for b-vitamins, lipoic acid and L-carnatine.

6. DPPIV/CD26- the wakefield kids in essense. Damaged enzymes for the gut to break down protein (mercury deactivates this) When you have weak adenosine daminase you have toxicity in all your t-cells.

Now, on to "how to inhibit peptides"
1. You have a glycosylation disruptor (in other words, you ain't making glycoproteins becuase you are missing sugar chains, ....hmmmm? Where did I hear that language before heh?

2. You have digestive disorders

3. You have High Exorphin Uptake

4. You have inhibitied adenosine deaminase binding problems (this helps you build up toxic xenobiotics-often messes with immune regulation, ARGH, that would be my kids )

5. YOU USE FLOURIDES and the FLOURIDES USE YOU LOL

6. You have genetic weaknesses (I like to call them poisened genes myself)

7. You have an accumulation of metals (everyone)

8. You used antibiotics toooo much

9. You have disulfide promotors (any takers on that one?)

10 You have organ brush border dysfunction (your bile duct is insufficient for example)-secretin kids for this problem. (pancreas duct, small intestine mucosal crypts, kidney mirovillar membrane)

In digestive disorder you have MALABSORPTION (your kid is basically starving to death even though they eat like a dump truck, you have peptide excesses, you have high dysbiosis, high permeability, toxic influxes and a detox burden. (basically a sick puppy).

Exorphins can be CNS opiate excesses, CNS immune dysregulations, Abnormal neuronal development and trophic changes to brain tissue (YIKES, an argument probably for FGF fibroblaste growth factor). Methyliation-an important sequence to NOT IGNORE.
Most of these kids have excess or impaired S-Adenosyle-Hcy. THIS CALLS FOR MORE ZINC supplementation (do not do AT MEALS he said).

Methyliation is needed to REMOVE ANTIMONY!!! IF you have a weakness then you get- PFK then your cells kick out uric acid which makes it even harder to remove (he mentioned that antimony is FOUND IN SLEEPERS, MATTRESSES ect. *(basically a flame retardant chemical)* He mentions to improve methyliation is B-6, folate, B-12 and Serine and even SAMe.

He recommends the following tests:
Urine Peptide analysis, casomorphine and gluteomorphns, IAG
Urine Amino Acids
Lymphotye differential
Hair element analysis (doctors data)
Stool analysis for digestive factors and dysbiotic or beneficial flora
Organic Acid Analysis
Food Inhalent workup
Blood Cell element analysis
Toxic Chemicals Panel
Oxidative Stress Panel
Adrenal Panel
Strict, I mean, STRICT gluten and glidin and cassein removal
Vitamin factors pull s-adenosyl, hcy along with normal methione
metabolic sequences. He suggest 5mg of methionine and DMAE, L-Glutamine, EnZYME
Aid, Antioxidants, Avoid Toxic chemicals, Zinc (without meals) and Calcium
and Magnesium.

Karen Serroussi
Her child from the get go Cried, Cranky, didn't sleep well, had severe DPT Injuries each succeeding the other (until a febrile collapse) -(sounds familiar). These kids often giggle or cry for no reason (she put up a sign of a drug addict symptoms, they were the SAME!!!!!)

You cannot think on the GF CF diet that a little won't hurt. She heard one mom detected that bread crumbs in the toaster were giving her child enough gluten opiods.

Usually these kids (reemphasizing the wakefield piece) a distended belly (yep). SHE RECOMMENDED EVERYONE TO GET AN ABdominalX-ray. Usually these kids have constipation. Interestingly becuase of that GREAT PAIN. MILK seems to MASK the pain of their fecal impactions by giving them enough pain killers to make it go away, NO WONDER THEY CRAVE IT!.

Use Acidophilus to keep gut in check. She believes that some kids are geneticially predisposed to IMPROPER IMMUNE RESPONSES (DING DING DING). She said try ethnic foods, fruits, vegees, rice and potatoes and dairy free milk (does anyone know if dairy free has Vitamin A palimate?) She made some moms cry, this one included....need I say more.

Dr Bradstreet

What's broken?
1. Genetic/Environmental susceptability

2. Vaccine Injury( at the conference they said a new paper is coming
out about aluminum toxicity tooooo)

3. Chronic GI inflammatory bowel disease

4. Autoimmunity or poor immunity (TH1 and TH2-the later being
autoimmunity, aint a working right)

5 Abnormal myelination (this disturbs him the most, becuase this is
what he sees in his child. EEG, QEEG (a new diagnoster tool) and MEG
abnormatlies are seen in these kids

6. Heavy Metals Toxicity (he chelated his whole family, even his wife
who is a dentist argh!)

7***THIS IS THE NEW BIGEE HE IS SEEING< PAY ATTENTION HERE!! ISAC or
Immune System Activation of Coagulation!!!-sees this mostly in the MOMs and DADS of these kids. They will put you in the grave early, thus his attention to it, since we need to stick around to take care of our kids. HE said our kids often have this as well, unfortunately, even in the brain, in which you have fibral balls that surround your red blood cells, making them harder to "flow". This results in stroke, heart disases, and unfortunately can limit blood flow in the brain. Do a Test on that, see below for further info.

8. Exogenous opiods

9. Pathogens such as yeast, parasties, bacteria, and viruses.

10. Abnormal neurotransmitter function (too much dopamine and
seratonin)

HE is recommending lately the use of GABA and TAURINE in the abnormal neurotransmitter kids. They often also have Low Lymphocytes, Multiple infections, Chronic Diahreeah, Mercury Toxicity and Positive MBP and or a NFP's

Ok, the clotting disorder. It is called THROMBOPHILIA. It makes the red blood cells thick and sticky. Interesting a picture of it looks like "lips" literally instead of round blood cells. These coagulators often control how proteins function in your body (ding ding). In these families, there is a tendancy towards BLOOD CLOTS. The test you can take is called LIPOPROTEIN A or a soluble fibril monumer. He said that 20 out of 24 autistic parents AND AUTISTICS seen in this new test showed this disorder. They usually have Protein C and S deficiences and are Vitamin K Dependant (interestingly, I put that in my sons protocol as a suggestion for a mito disease). They
have APC resistance (whatever that means?), Increased Lipoproteins, Platelet
Activation and increased Prothrombin or Factor II.

A must nutrient, here we go again, ZINC. Zinc deficiency can equal problems in myelin formation. He also mentioned Selenium. He said that in 90% of his patients, they all seem to have copper excess! They definately have Mercury and Lead and Aluminum and antimony
problems.

They usually have Omega 3 fatty acid deficiencies (as does mom-which is
passed on to child), they have Antioxidant deficiencies as well. He recommends Colustrum Gold.

Th2 predominately in kids with High IGE (gee, my kids had really really high, a problem? OH YES). He talked about DMSA and HG/Pb Fda Approved for children. DMSA links to Hg, Pb, Cd, and Zn- the latter being zinc. PUT ZINC back in the body after every round!!!
3 days on-11 days off (pulse therapy). Newer versions uses lowered levels of NAC to DMSA. Melatonin pretects from freed Hg. Replace also glutathione and Cysteine.

Well, that along with lovely stories of Dr Rimlands son, made for a wonderful day. I met a lot of my online friends as well. POWER TO THE MOMS AND DADS. Truly a very wonderful day. By the by the, Kirkman will be making the epsom cream I suggested they make. They loved the idea, look for that in the future!
--------------------------------------------------------------------------------

[Ilsa]

6. Wow, that is alot of possibilites for autism.

My son's hair has been tested; negative.

He has had antibiotics maybe three times in his life. He was breastfed and had maybe two or three ear infections in 11 years.

I've started giving my son some extra magnesium, and he likes epsom salts baths. I wonder about deficiencies.

His bowel movements are not an issue. He's never had problems.

I gotta run. He's having some issues right now.

[HysteryDiagnosis]

7. Somewhere you may want to read or perhaps take a trip to.....

www.hriptc.org

[Ilsa]

10. Thank you so much for everything you've put into this thread.

Your graciousness has been a blessing for me. Sometimes we feel alone in our struggle, especially now with the changes in my son's behavior over the last week. It's good to know that others are willing to take the time to bring up good info.

I've thought about looking for new places to go and get diagnostic work. I don't trust all of them, unfortunately. We're in Texas, and I don't know of any centers like this here.

BTW, I registered online for the Nature articles. Of course, I'll mostly just get abstracts, but that is helpful too.

[SheilaT]

8. Interesting. But it's important to realize

that there is not one cause, nor one solution to autism.

I have two sons. Both have an auto-immune disorder, alopecia areata. It causes hair loss. Both of them are totally bald. No hair on their heads, no eyebrows, no eyelashes, no body hair whatsoever. The oldest son is mildly autistic. He has Asperger's Syndrome. He developed alopecia areata at age 3. The younger one is as opposite from being autistic as a person can be, is very social, plays well with others, has many friends. He lost his hair at age 10.

Since I have been involved with the alopecia thing for about twenty years now, I'm quite familiar with people looking for the magic solution to a particular problem. And trust me, it doesn't exist. There are those in the alopecia world who are absolutely convinced that diet, or environmental toxins, or vaccinations are the cause of hair loss. But none of those can be adequately demonstrated.

And I propose that the same is related to autism. There are many causes, many connections. It may be that for one autistic person a change in diet will produce dramatic improvement. Maybe for some others vaccinations triggered a change that was autism. I can tell you that my autistic son was different, that is to say autistic, from the very beginning. For him it wasn't diet (and he was breast fed exclusively for more than six months, and then finally weaned at age two) and it wasn't vaccinations and it wasn't environmental toxins. He was born with this difference.

It may well be that for others things are different. I just want to urge caution to those who suddenly think they've found the magic cure, or the magical cause.

[HysteryDiagnosis]

9. Thank you, it couldn't have been said better or in a more polite

manner.