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Pycnogenol and Diabetic Nephropathy

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HysteryDiagnosis Donating Member (1000+ posts) Send PM | Profile | Ignore Thu Dec-08-11 08:25 PM
Original message
Pycnogenol and Diabetic Nephropathy
Edited on Thu Dec-08-11 08:26 PM by HysteryDiagnosis
Basically this is saying that people who constantly harp on the fallacious merits of supplements are fantastically misinformed.


http://www.ncbi.nlm.nih.gov/pubmed/21689714

Food Chem Toxicol. 2011 Sep;49(9):2196-201. Epub 2011 Jun 12.
Pycnogenol modulates apoptosis by suppressing oxidative stress and inflammation in high glucose-treated renal tubular cells.
Kim YJ, Kim YA, Yokozawa T.
Source

Department of Dental Hygiene, Busan Women's University, Busanjin-Gu, Busan 614-734, Republic of Korea.
Abstract

Compelling evidence indicates that polyphenolic antioxidants protect against diabetic nephropathy. Pycnogenol is made up of flavonoids, mainly procyanidins and phenolic compounds, and is a known powerful antioxidant. Hyperglycemia is characteristic of diabetic nephropathy and induces renal tubular cell apoptosis.

Thus, in this study, we used high glucose-treated renal tubular cells to investigate the protective action of pycnogenol against high glucose-induced apoptosis and diabetic nephropathy. We also sought to further delineate the underlying mechanisms elicited by oxidative stress and inflammation and suppressed by pycnogenol. Results show that pycnogenol significantly suppressed the high glucose-induced morphological changes and the reduction in cell viability associated with cytotoxicity. Bcl2/Bax protein levels indicated pycnogenol's anti-apoptotic effect against high glucose-induced apoptotic cell death.

In addition, several key markers of oxidative stress and inflammation were measured for pycnogenol's beneficial effects. Results indicate pycnogenol's anti-oxidative and anti-inflammatory efficacy in suppressing lipid peroxidation, total reactive species (RS), superoxide (()O(2)), nitric oxide (NO()), peroxynitrite (ONOO(-)), pro-inflammatory inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), and nuclear factor-kappa B (NF-κB) nuclear translocation.

Based on these results, we conclude that pycnogenol's anti-oxidative and anti-inflammatory properties underlie its anti-apoptotic effects, suggesting further investigation of pycnogenol as a promising treatment against diabetic nephropathy.
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truedelphi Donating Member (1000+ posts) Send PM | Profile | Ignore Thu Dec-08-11 08:37 PM
Response to Original message
1. k & R. Question though - what foods contain this
Nutritional element? It's not that I won't take a supplement, but I do prefer to take real food that contains the needed ingredient(s).



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grasswire Donating Member (1000+ posts) Send PM | Profile | Ignore Thu Dec-08-11 08:39 PM
Response to Reply #1
3. pine bark extract n't
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HysteryDiagnosis Donating Member (1000+ posts) Send PM | Profile | Ignore Thu Dec-08-11 09:50 PM
Response to Reply #1
7. You could check out the library at
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trotsky Donating Member (1000+ posts) Send PM | Profile | Ignore Thu Dec-08-11 08:39 PM
Response to Original message
2. Unrec for your woefully misstated editorial comment. n/t
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TheDebbieDee Donating Member (1000+ posts) Send PM | Profile | Ignore Thu Dec-08-11 09:08 PM
Response to Reply #2
4. "Rec'ing" solely to cancel out your "unrec". Everyone should feel
free to state their opinions. After all, this is a forum...........
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HuckleB Donating Member (1000+ posts) Send PM | Profile | Ignore Thu Dec-08-11 09:39 PM
Response to Reply #4
5. This explains the ongoing problem with the "opinion" in the OP.
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trotsky Donating Member (1000+ posts) Send PM | Profile | Ignore Thu Dec-08-11 09:46 PM
Response to Reply #4
6. Never said he couldn't.
But I'm allowed to have mine, too.
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BuddhaGirl Donating Member (1000+ posts) Send PM | Profile | Ignore Fri Dec-09-11 03:54 PM
Response to Original message
8. K & R
for great information :thumbsup:
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