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Demeter Donating Member (1000+ posts) Send PM | Profile | Ignore Fri Jun-26-09 06:27 AM
Original message
New cancer treatment shows ‘great promise’
Source: Financial Times



By Clive Cookson in London



A new way of treating cancer has shown “great promise” in its first clinical trial at the Royal Marsden Hospital in London. Researchers gave olaparib, a drug being developed by AstraZeneca with the UK Institute for Cancer Research, to 60 patients with advanced breast, ovarian and prostate cancers. All had mutations in the BRCA1 and BRCA2 genes associated with inherited forms of these cancers.

“This drug showed very impressive results in shrinking patients’ tumours,” said Dr Johann de Bono of the ICR. “It is giving patients who have already tried many conventional treatments long periods of remission, free from the symptoms of cancer or major side-effects.”

Olaparib kills cancer cells but leaves healthy cells relatively unscathed. The drug blocks an enzyme called Parp, which is involved in repairing DNA defects in human cells. Healthy cells can mend their DNA through alternative biological pathways, but cancer cells carrying the BRCA1 and BRCA2 genes do not have alternative repair mechanisms – and they die in the presence of the drug.

BRCA1 and BRCA2 mutations are responsible for about 5 per cent of breast cancers – though these occur in younger women and tend to be particularly aggressive tumours. The same mutations are also implicated in some ovarian and prostate cancers. But ICR scientists predict that olaparib and other drugs that work in the same way – known as Parp inhibitors – will also be effective against many non-BRCA cancers that have different DNA repair defects. They believe up to half of the most common type of ovarian cancers could respond to olaparib treatment.



Read more: http://www.ft.com/cms/s/0/f6fa6bd0-60dc-11de-aa12-00144...
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TwilightGardener Donating Member (1000+ posts) Send PM | Profile | Ignore Fri Jun-26-09 06:43 AM
Response to Original message
1. That's really cool. Hope it continues to show effectiveness over time.
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salguine Donating Member (1000+ posts) Send PM | Profile | Ignore Fri Jun-26-09 07:05 AM
Response to Original message
2. This is great news. The downside is, if you have no insurance you don't get it, and
if you DO have insurance, they'll figure out a way not to cover it, so either way you don't get this fantastic new treatment.
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Technowitch Donating Member (1000+ posts) Send PM | Profile | Ignore Sat Jun-27-09 12:03 AM
Response to Reply #2
14. That's just in America
In the rest of the civilized world, if/when this treatment is proven truly effective, their national healthcare systems will quickly adopt it as a front-line measure.

We've been living in the alligator pit for so long, we've all forgotten what it's like to have an alligator-free existence.
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A Simple Game Donating Member (1000+ posts) Send PM | Profile | Ignore Fri Jun-26-09 07:25 AM
Response to Original message
3. Impossible.
Just ask any Republican.

Nothing good or innovative ever came out of the British single payer health system.
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madmom Donating Member (1000+ posts) Send PM | Profile | Ignore Fri Jun-26-09 08:39 AM
Response to Original message
4. Wait a minute. I thought, according the big pharma, they have to charge us higher prices for our
meds and treatments, or they wouldn't have money for research. Now here we have a place with public health care and they may have found a cure for cancer? What am I missing here?
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PA Democrat Donating Member (1000+ posts) Send PM | Profile | Ignore Fri Jun-26-09 10:48 AM
Response to Reply #4
9. I had the exact same comment.
Of course what big pharma fails to tell the public here in the US is that half of the drug development is done through funding by either the government or non-profits. And then you have to consider that a big chunk of the research that big pharma DOES fund is for copycat drugs and for wonderful things like Viagra.
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Peggy Day Donating Member (859 posts) Send PM | Profile | Ignore Fri Jun-26-09 08:39 AM
Response to Original message
5. Man, the stock costs over $2,700/share
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Joanne98 Donating Member (1000+ posts) Send PM | Profile | Ignore Fri Jun-26-09 08:58 AM
Response to Reply #5
6. Oh my God.
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goclark Donating Member (1000+ posts) Send PM | Profile | Ignore Fri Jun-26-09 09:50 AM
Response to Original message
7. Isn't this the same treatment being tried at the Cleveland Hospital?

Thrilling, simply thrilling!

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cpompilo Donating Member (125 posts) Send PM | Profile | Ignore Fri Jun-26-09 10:36 AM
Response to Original message
8. Low Dose Naltrexone also shows great promise for
cancer, HIV AIDS, auto-immune diseases. And it's cheap. Here is the website: www.LowDoseNaltrexone.org
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jkappy Donating Member (214 posts) Send PM | Profile | Ignore Fri Jun-26-09 11:54 AM
Response to Original message
10. the 10,000th cancer drug/treatment to show "great promise"
reported in the US mainstream media.
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Demeter Donating Member (1000+ posts) Send PM | Profile | Ignore Fri Jun-26-09 02:12 PM
Response to Reply #10
11. This was NOT American MSM
This is a reputable UK Publication. It's one of the few places I can find real news that holds up to time.
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Odin2005 Donating Member (1000+ posts) Send PM | Profile | Ignore Fri Jun-26-09 02:39 PM
Response to Original message
12. The Alternative "Medicine" people are already looking for a excuse to call it evil.
:yoiks:
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dflprincess Donating Member (1000+ posts) Send PM | Profile | Ignore Fri Jun-26-09 10:00 PM
Response to Original message
13. The UK Institute for Cancer Research?
I thought :scared:SOCIALIZED MEDICINE :scared: discouraged research.

Another myth busted.
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