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Reply #91: Thanks for your post and I'm glad to hear that you healed [View All]

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seleff Donating Member (94 posts) Send PM | Profile | Ignore Sat Apr-08-06 11:48 AM
Response to Reply #49
91. Thanks for your post and I'm glad to hear that you healed
I agree that the genetics literature is stuffed with these type of (weak) linkage studies, and this particular one isn't really showing linkage, just supporting some kind of pre-disposing factor comparing twins to sibs. I don't expect to look at a chromosomal map in 30 years and see an Anx-1 locus or anything (unless we're talking about a locus contributing to anxiety/depression...even then it will be a pre-disposing site, not a determinant site). As a biochemist and MD I expect that you are struck by the physiologically intense and powerful grip that your anorexia developed as you became low weight, where you could restrict even while starving. I haven't done enough reading to see if I agree that there is a good link between endorphin action and desensitizing to the hunger response, but it was cited in therapy with my daughter along the way. I read a paper by a clinician at the U Minn (don't remember the name) that proposed that anorexia responses may have evolved in human (women) descended from migrating populations (indo-europeans, but less so in africans) as a means of maintaining energy levels to tend to children while the tribe was trying to escape famine. The article posed some compelling arguments, but I don't remember them all.

While I agree that psychosocial factors dominate this disease, the biological pattern and commonality of signs and symptoms in restricting anorexics compel me to believe that there are/will be genetic factors identified that pre-dispose some women to developing this disorder. 18 months of on and off family therapy (and talking to my daughter's therapists the first 8 months of her disorder) have failed to really pinpoint any "blame" for my daughter's condition. I've shared some of the possible factors in one of my other posts. Several authors I've read point out that the family may or may not be "to blame". In my daughter's case i think several factors came together. 1) she had had two previous experiences with a precipitous depression that came and went suddenly in the course of 2-4 weeks; 2) she has had a crisis in her teenage life where she deeply wants to "be somebody" or achieve something great, without knowing what. Early success in distance running as a ninth grader made her think she could train to excellence so she really trained the summer before her So. yr and dropped weight from 103 to 80 lbs running cross-country in the fall. We didn't see the signs of anorexia until she had dropped below 88 lbs, partly because everyone was excited with her drops in time and becoming a State -ranked runner along the way. Her therapy has had to deal with this yearning for identity. Maybe spirituality (we do not practice organized religion in our family although we celebrate jewish holidays, and Latvian cultural holidys-Xmas "winterfestival" and easter (egg hunts)) might be helpful to her. Any advice would be helpful along these lines.; 3) her older sistr went off to college and my mother in law died of cancer the year before. My (anorexic) daughter feels very close to both (especially "ol'mom") and both could have offered much support (older sister did) recognizing what was going on and in recovery. Instead, my daughter grasped onto an older girl on the cross country team who was a normal weight anorexic and who was very strong about "watching what you eat". I believe that my daughter always worried about "what would Anna say" when she approached food, and used Anna almost as a spiritual guru in her development of restrictive eating patterns.

Even though my daughter has recovered her normal weight (103 lbs), the disease has scarred her body and mind. For awhile, it really wrecked our fathr-daughtr relationship, which has gotten bettr.I keep hoping that the scars will fade.

Gotta run to take my 11 yr old son to get sushi (his favorite) for lunch!
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  -Study: More than half of risk for developing anorexia is genetic HuckleB  Apr-07-06 08:39 AM   #0 
  - Why do you keep posting about anorexia on the GD page? Are you  WiseButAngrySara   Apr-07-06 08:48 AM   #1 
  - Do you really believe that?  Warpy   Apr-07-06 08:55 AM   #2 
  - Holy Anorexia is the LEAST likely to have a genetic component...and  WiseButAngrySara   Apr-07-06 09:02 AM   #4 
  - Hardly. Saintly women (who proved themselves saintly by  Warpy   Apr-07-06 09:30 AM   #11 
     - I read your article, and it supported my belief. Greeks (like Plato), the  WiseButAngrySara   Apr-07-06 10:20 AM   #19 
  - Maybe it's always been around, but I think there's much more of  raccoon   Apr-07-06 09:05 AM   #6 
     - Please read the links I posted, as well as the one Warpy posted.  HuckleB   Apr-07-06 10:06 AM   #15 
        - Self delete nt  raccoon   Apr-07-06 10:37 AM   #25 
           - .  HuckleB   Apr-07-06 10:40 AM   #26 
  - Perhaps because some people here probably are anorexic  lukasahero   Apr-07-06 09:02 AM   #3 
  - You tell me how you developed anorexia. Most anorexics know that it's  WiseButAngrySara   Apr-07-06 09:19 AM   #10 
  - Funny you make that assumption  lukasahero   Apr-07-06 10:46 AM   #30 
     - "your parents" and "their daughter" and your hostile defense...what would  WiseButAngrySara   Apr-07-06 10:59 AM   #36 
        - It was deliberate  lukasahero   Apr-07-06 11:06 AM   #38 
  - Even in families with strong genetic factors, the environment plays  ShortnFiery   Apr-07-06 12:48 PM   #59 
     - I agree with you entirely  lukasahero   Apr-07-06 12:59 PM   #63 
        - The author of this post has posted numerous articles in GD on anorexia  WiseButAngrySara   Apr-07-06 01:27 PM   #72 
           - Numerous?  HuckleB   Apr-07-06 01:53 PM   #75 
           - Deleted sub-thread  Name removed   Apr-07-06 02:11 PM   #78 
           - I don't think "blaming" is the right word  KurtNYC   Apr-07-06 02:04 PM   #77 
  - Mental illnesses can have a genetic component  AngryAmish   Apr-07-06 09:04 AM   #5 
  - I disagree with you, I had the disease and now my daughter has it  wisteria   Apr-07-06 09:07 AM   #7 
  - One hears about ladies who "went into a decline"....  Bridget Burke   Apr-07-06 10:24 AM   #21 
     - That's true! I never thought of that...  LostinVA   Apr-07-06 10:48 AM   #33 
        - And in the old days, those ladies were often turned over to doctors....  Bridget Burke   Apr-07-06 11:06 AM   #39 
           - Ick. I know... excessive bleeding killed Lord Byron, and probably  LostinVA   Apr-07-06 11:10 AM   #40 
  - wow. feeling a little angry but insensitive today? eom  freeplessinseattle   Apr-07-06 09:15 AM   #9 
  - Wisdom speaks for truth. If there is a genetic component in eating  WiseButAngrySara   Apr-07-06 09:32 AM   #12 
     - Funny, the evidence available clearly disagrees.  HuckleB   Apr-07-06 10:09 AM   #16 
     - Why can't it be both?  SmokingJacket   Apr-07-06 10:20 AM   #18 
     - I never argued otherwise, but like alcoholism, it has to be a very minor  WiseButAngrySara   Apr-07-06 10:28 AM   #22 
        - It's not a minor component in alcoholism  LostinVA   Apr-07-06 10:45 AM   #29 
        - I would argue that in the context of most alcoholics blaming it on their  WiseButAngrySara   Apr-07-06 12:35 PM   #54 
           - Not if they are an alcoholic. Alcoholism is a disease  LostinVA   Apr-07-06 12:47 PM   #58 
        - That's not medically supported  XemaSab   Apr-07-06 01:36 PM   #73 
     - "Blaming" conditions on genetics so you can ignore them....  Bridget Burke   Apr-07-06 10:44 AM   #28 
        - Exactly.  HuckleB   Apr-07-06 10:49 AM   #34 
  - It is the general discussion page.  HuckleB   Apr-07-06 10:01 AM   #13 
  - One of my dearest friends is the director of an eating disorders clinic in  WiseButAngrySara   Apr-07-06 11:48 AM   #47 
     - Oh brother.  HuckleB   Apr-07-06 12:25 PM   #50 
        - Deleted message  Name removed   Apr-07-06 12:33 PM   #52 
           - Sorry, I've been around too long to buy into such game playing...  HuckleB   Apr-07-06 12:36 PM   #55 
              - It most certanly does exist, and you would recognize the medical center.  WiseButAngrySara   Apr-07-06 01:04 PM   #66 
                 - LOL!  HuckleB   Apr-07-06 01:07 PM   #69 
                    - Lady, I just did a search on all of your posts, and the only posts on  WiseButAngrySara   Apr-07-06 01:18 PM   #70 
                       - Deleted message  Name removed   Apr-07-06 01:51 PM   #74 
                       - Lady?  HuckleB   Apr-07-06 07:28 PM   #83 
  - Anorexic daughter, family history of depression/anxiety  seleff   Apr-07-06 10:35 AM   #24 
  - See post #47. I not only have a personal distant history of anorexia,  WiseButAngrySara   Apr-07-06 12:25 PM   #49 
     - Thanks for your post and I'm glad to hear that you healed  seleff   Apr-08-06 11:48 AM   #91 
     - Seleff, I'm working on a response to both of your posts, and I will PM  WiseButAngrySara   Apr-09-06 10:58 AM   #92 
     - No competent scientist would value "personal authority" over controlled  spooky3   May-14-06 01:59 PM   #95 
  - Very legit studies have shown it bridges generations  LostinVA   Apr-07-06 10:41 AM   #27 
  - Hasn't it been linked to  mzteris   Apr-07-06 11:30 AM   #43 
     - The comorbidity percentage is quite significant.  HuckleB   Apr-07-06 11:34 AM   #44 
  - So why would it be increasing?  SmokingJacket   Apr-07-06 09:13 AM   #8 
  - No one is denying environmental factors play a part.  HuckleB   Apr-07-06 10:03 AM   #14 
  - Sorry, misread your OP!  SmokingJacket   Apr-07-06 10:15 AM   #17 
  - I think the incidence of anorexia is going down  KurtNYC   Apr-07-06 10:35 AM   #23 
     - It's actually difficult to note...  HuckleB   Apr-07-06 10:46 AM   #31 
     - Googling for studies and using the word "control"  KurtNYC   Apr-07-06 01:04 PM   #67 
     - Your citations jive with our experience  seleff   Apr-07-06 11:04 AM   #37 
     - Well, I have my own theories...  SmokingJacket   Apr-07-06 11:43 AM   #45 
     - I can so relate to this...the perfectionism, the strange ecstatic 'high'  WiseButAngrySara   Apr-07-06 12:44 PM   #56 
     - I'm glad you're modifying your opinion.  Bridget Burke   Apr-07-06 02:45 PM   #80 
     - A very thoughtful post.  HuckleB   Apr-07-06 12:56 PM   #61 
        - Like I said, it's just my own personal theorizing...  SmokingJacket   Apr-07-06 02:14 PM   #79 
           - It's not silly.  HuckleB   Apr-07-06 07:34 PM   #87 
              - Thank you...  SmokingJacket   Apr-07-06 07:59 PM   #88 
     - I think the incidence  diamidue   Apr-07-06 01:02 PM   #65 
        - Re: differences and definitions/criteria  HuckleB   Apr-07-06 01:05 PM   #68 
        - Exactly, I had a distorted body image and a need to feel in control of  wisteria   Apr-07-06 01:59 PM   #76 
  - Thanks for the post and links ....  etherealtruth   Apr-07-06 10:24 AM   #20 
  - I think you got it right.  HuckleB   Apr-07-06 07:31 PM   #86 
  - Then why was anorexia not rampant in the 30's or 40s or 50s??  progressivebydesign   Apr-07-06 10:46 AM   #32 
  - Please read the actual articles...  HuckleB   Apr-07-06 10:51 AM   #35 
  - How do you know it wasn't?  LostinVA   Apr-07-06 11:11 AM   #41 
  - you ever really looked  mzteris   Apr-07-06 12:02 PM   #48 
  - Thin does not mean anorexic  diamidue   Apr-07-06 11:12 AM   #42 
  - So, it's like a genetic OCD basically?  porphyrian   Apr-07-06 11:47 AM   #46 
  - FYI...  HuckleB   Apr-07-06 12:35 PM   #53 
  - Of course they want to find a "genetic basis"...  VelmaD   Apr-07-06 12:29 PM   #51 
  - Wrong.  HuckleB   Apr-07-06 12:45 PM   #57 
  - Thanks! I agree. More money for the pharmaceutical industry. n/t  WiseButAngrySara   Apr-07-06 12:52 PM   #60 
  - Please show us how the pharm industry is trying to make money...  HuckleB   Apr-07-06 12:58 PM   #62 
  - Maybe side effect profiles in depression studies will promote successful o  seleff   Apr-08-06 11:06 AM   #90 
     - Small studies are being done, and have been done.  HuckleB   Apr-10-06 07:58 AM   #94 
  - Yeah, because it's not like big pharma is making any money  lukasahero   Apr-07-06 01:01 PM   #64 
  - Bullshit!  Odin2005   Apr-07-06 01:23 PM   #71 
  - Some books on the psychosocial origin; Genetics has to explain why no men.  WiseButAngrySara   Apr-07-06 04:46 PM   #81 
  - All published before most of the actual research on anorexia occurred.  HuckleB   Apr-07-06 07:30 PM   #84 
  - I knew an anorexic guy.  SmokingJacket   Apr-07-06 08:08 PM   #89 
  - The leader of my eating disorder support group says:  Nikia   Apr-07-06 06:06 PM   #82 
     - Good post.  HuckleB   Apr-07-06 07:30 PM   #85 
     - Very true...  varkam   Apr-09-06 01:46 PM   #93 

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