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Reply #44: I take your point well..... and I understand that supplements are not [View All]

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HysteryDiagnosis Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Jul-10-05 03:26 PM
Response to Reply #43
44. I take your point well..... and I understand that supplements are not
a good alternative to a PROVEN THERAPY. But, when a profession that likes to tout it's high level of research and proclaim that they are practicing evidence based medicine, ignore a person's

ascorbic acid status

antioxidant status

reduced glutathione status

coenzyme q10 status

the very items that normally keep a cancer from taking root in a person parhaps every day of their lives... I get perturbed.

Yes, more than one study is needed... and they will be done. The best results are going to be derived from trials that apply glyconutrients against cancer (in addition to traditional interventions) as was exampled in this study. These papers are speaking of simply one aloe polymannose. The complete glyconutrient complex is capable of so much more.


1: Mol Biother. 1991 Jun;3(2) :79-87. Related Articles, Links


Decreased mortality of Norman murine sarcoma in mice treated with the immunomodulator, Acemannan.

Peng SY, Norman J, Curtin G, Corrier D, McDaniel HR, Busbee D.

Department of Anatomy, College of Veterinary Medicine, Texas A & M University, College Station 77843.

An extract from the parenchyma of Aloe barbadensis Miller shown to contain long chain polydispersed beta (1,4)-linked mannan polymers with random O-acetyl groups (acemannan, Carrisyn) was found to initiate the phagocyte production of monokines that supported antibody dependent cellular cytotoxicity and stimulated blastogenesis in thymocytes. Acemannan, in both enriched and highly purified forms, was administered intraperitoneally to female CFW mice into which murine sarcoma cells had been subcutaneously implanted. The rapidly growing, highly malignant and invasive sarcoma grew in 100% of implanted control animals, resulting in mortality in 20 to 46 days, dependent on the number of cells implanted. Approximately 40% of animals treated with acemannan at the time of tumor cell implantation (1.5 x 10(6) cells) survived. Tumors in acemannan-treated animals exhibited vascular congestion, edema, polymorphonuclear leukocyte infiltration, and central necrosing foci with hemorrhage and peripheral fibrosis. The data indicate that in vivo treatment of peritoneal macrophages stimulates the macrophage production of monokines, including interleukin-1 and tumor necrosis factor. The data further indicate that sarcomas in animals treated i.p. with acemannan at the time of tumor cell implantation were infiltrated by immune system cells, became necrotic, and regressed. The combined data suggest that acemannan-stimulated synthesis of monokines resulted in the initiation of immune attack, necrosis, and regression of implanted sarcomas in mice.

PMID: 1910624



1: Immunopharmacology. 1996 Nov;35(2):119-28. Related Articles, Links


Activation of a mouse macrophage cell line by acemannan: the major carbohydrate fraction from Aloe vera gel.

Zhang L, Tizard IR.

Department of Veterinary Pathobiology, Texas A & M University College Station 77843, USA.

Acemannan is the name given to the major carbohydrate fraction obtained from the gel of the Aloe vera leaf. It has been claimed to have several important therapeutic properties including acceleration of wound healing, immune stimulation, anti-cancer and anti-viral effects. However, the biological mechanisms of these activities are unclear. Because of this wide diversity of effects, it is believed that they may be exerted through pluripotent effector cells such as macrophages. The effects of acemannan on the mouse macrophage cell line, RAW 264.7 cells were therefore investigated. It was found that acemannan could stimulate macrophage cytokine production, nitric oxide release, surface molecule expression, and cell morphologic changes. The production of the cytokines IL-6 and TNF-alpha were dependent on the dose of acemannan provided. Nitric oxide production, cell morphologic changes and surface antigen expression were increased in response to stimulation by a mixture of acemannan and IFN-gamma. These results suggest that acemannan may function, at least in part, through macrophage activation.

PMID: 8956975

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