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Reply #44: I take your point well..... and I understand that supplements are not [View All]

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HysteryDiagnosis Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Jul-10-05 03:26 PM
Response to Reply #43
44. I take your point well..... and I understand that supplements are not
a good alternative to a PROVEN THERAPY. But, when a profession that likes to tout it's high level of research and proclaim that they are practicing evidence based medicine, ignore a person's

ascorbic acid status

antioxidant status

reduced glutathione status

coenzyme q10 status

the very items that normally keep a cancer from taking root in a person parhaps every day of their lives... I get perturbed.

Yes, more than one study is needed... and they will be done. The best results are going to be derived from trials that apply glyconutrients against cancer (in addition to traditional interventions) as was exampled in this study. These papers are speaking of simply one aloe polymannose. The complete glyconutrient complex is capable of so much more.

1: Mol Biother. 1991 Jun;3(2) :79-87. Related Articles, Links

Decreased mortality of Norman murine sarcoma in mice treated with the immunomodulator, Acemannan.

Peng SY, Norman J, Curtin G, Corrier D, McDaniel HR, Busbee D.

Department of Anatomy, College of Veterinary Medicine, Texas A & M University, College Station 77843.

An extract from the parenchyma of Aloe barbadensis Miller shown to contain long chain polydispersed beta (1,4)-linked mannan polymers with random O-acetyl groups (acemannan, Carrisyn) was found to initiate the phagocyte production of monokines that supported antibody dependent cellular cytotoxicity and stimulated blastogenesis in thymocytes. Acemannan, in both enriched and highly purified forms, was administered intraperitoneally to female CFW mice into which murine sarcoma cells had been subcutaneously implanted. The rapidly growing, highly malignant and invasive sarcoma grew in 100% of implanted control animals, resulting in mortality in 20 to 46 days, dependent on the number of cells implanted. Approximately 40% of animals treated with acemannan at the time of tumor cell implantation (1.5 x 10(6) cells) survived. Tumors in acemannan-treated animals exhibited vascular congestion, edema, polymorphonuclear leukocyte infiltration, and central necrosing foci with hemorrhage and peripheral fibrosis. The data indicate that in vivo treatment of peritoneal macrophages stimulates the macrophage production of monokines, including interleukin-1 and tumor necrosis factor. The data further indicate that sarcomas in animals treated i.p. with acemannan at the time of tumor cell implantation were infiltrated by immune system cells, became necrotic, and regressed. The combined data suggest that acemannan-stimulated synthesis of monokines resulted in the initiation of immune attack, necrosis, and regression of implanted sarcomas in mice.

PMID: 1910624

1: Immunopharmacology. 1996 Nov;35(2):119-28. Related Articles, Links

Activation of a mouse macrophage cell line by acemannan: the major carbohydrate fraction from Aloe vera gel.

Zhang L, Tizard IR.

Department of Veterinary Pathobiology, Texas A & M University College Station 77843, USA.

Acemannan is the name given to the major carbohydrate fraction obtained from the gel of the Aloe vera leaf. It has been claimed to have several important therapeutic properties including acceleration of wound healing, immune stimulation, anti-cancer and anti-viral effects. However, the biological mechanisms of these activities are unclear. Because of this wide diversity of effects, it is believed that they may be exerted through pluripotent effector cells such as macrophages. The effects of acemannan on the mouse macrophage cell line, RAW 264.7 cells were therefore investigated. It was found that acemannan could stimulate macrophage cytokine production, nitric oxide release, surface molecule expression, and cell morphologic changes. The production of the cytokines IL-6 and TNF-alpha were dependent on the dose of acemannan provided. Nitric oxide production, cell morphologic changes and surface antigen expression were increased in response to stimulation by a mixture of acemannan and IFN-gamma. These results suggest that acemannan may function, at least in part, through macrophage activation.

PMID: 8956975

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  -Fake Research Allegations Reach New Highs Judi Lynn  Jul-10-05 05:19 AM   #0 
  - You won't find this sort of thing in the supplement industry... but you  4MoronicYears   Jul-10-05 05:54 AM   #1 
  - There's Also A Network Of "Debunkers" Set Up To Smear Honest Research  cryingshame   Jul-10-05 09:19 AM   #5 
  - so, what's your beef with Randi?  Raster   Jul-10-05 09:29 AM   #6 
  - He Participated In A Smear Campaign Against A Scientist Whose Work  cryingshame   Jul-10-05 10:46 AM   #22 
     - who? what was the focus point for the research?  Raster   Jul-10-05 11:15 AM   #28 
  - Yes.... let's not let it out of the bag that spontaneous remissions occur  4MoronicYears   Jul-10-05 09:54 AM   #13 
  - Reminds me of a recent article.....  Catchawave   Jul-10-05 10:06 AM   #14 
  - Criminy..... how in the hell did they make that mistake???  4MoronicYears   Jul-10-05 10:10 AM   #15 
  - Your Attempt To Misdirect Discredits Any Point You Might Try To Make  cryingshame   Jul-10-05 10:47 AM   #23 
  - Yes, it's a rather large beef of mine since my father was chemo'd  4MoronicYears   Jul-10-05 11:00 AM   #25 
  - There are also many cases  Demgirl   Jul-10-05 11:34 AM   #31 
     - I noticed in your post a reference to breast cancer... what if, I say,  4MoronicYears   Jul-10-05 11:43 AM   #35 
     - I'm one.  donco6   Jul-10-05 01:23 PM   #39 
     - Hey - I'm one of the lucky ones - I seem able to take any of my meds  TankLV   Jul-10-05 01:24 PM   #40 
  - So why don't you go claim Randi's Megabuck prize?  BiggJawn   Jul-10-05 10:15 AM   #17 
  - Because Randi Is A Charlatan & Will ALWAYS Interject Himself Into A  cryingshame   Jul-10-05 10:45 AM   #21 
     - Sorry, but...  William Seger   Jul-10-05 11:58 AM   #36 
     - He is not  alarimer   Jul-10-05 02:13 PM   #41 
     - We could ask the same questions about the Snake-Oil salesmen...  BiggJawn   Jul-10-05 04:17 PM   #46 
  - Randi is no charlatan  William Seger   Jul-10-05 11:40 AM   #34 
     - Here, here!! nt  VegasWolf   Jul-10-05 12:08 PM   #38 
  - No one knows  Demgirl   Jul-10-05 09:34 AM   #9 
  - "Supplements industry refuses to use the peer review process"  BuddhaGirl   Jul-10-05 09:51 AM   #12 
     - You go girl..... people buy whatever the corporate sources tell them  4MoronicYears   Jul-10-05 10:13 AM   #16 
     - Supplement companies are corporations, too  union_maid   Jul-10-05 04:02 PM   #45 
     - Do you have a link?  Demgirl   Jul-10-05 10:27 AM   #19 
        - How does one conduct studies on oh, I don't know.. "broccoli" that  4MoronicYears   Jul-10-05 10:44 AM   #20 
           - Clinical trials for supplements  Demgirl   Jul-10-05 11:33 AM   #30 
              - Here it is in a nutshell..... I have listened to people who have been  4MoronicYears   Jul-10-05 11:38 AM   #33 
                 - Need more than one study  Demgirl   Jul-10-05 02:33 PM   #43 
                    - I take your point well..... and I understand that supplements are not  4MoronicYears   Jul-10-05 03:26 PM   #44 
  - right, like how safe and effective ephedra is  mopinko   Jul-10-05 11:04 AM   #26 
     - the ephedra ban was recently overtuned  BuddhaGirl   Jul-10-05 04:45 PM   #48 
  - The researches are now following the sterling example set by the WH.  fasttense   Jul-10-05 06:21 AM   #2 
  - and just about anybody else  nolabels   Jul-10-05 09:11 AM   #3 
  - welcome to the new Dark Ages n/t  rucky   Jul-10-05 09:32 AM   #8 
  - I Stand Partly Vindicated. The Science Industrial Complex Has Perverted  cryingshame   Jul-10-05 09:18 AM   #4 
  - bullshit  alarimer   Jul-10-05 02:19 PM   #42 
  - Fake science to support the fake economy. nt  bemildred   Jul-10-05 09:30 AM   #7 
  - Don't blame everyone  Demgirl   Jul-10-05 09:37 AM   #10 
  - Ahhh, remember the "smoking beagles" .......  Catchawave   Jul-10-05 09:49 AM   #11 
  - There's BIG BUCKS to be made in "cooking" Science!  BiggJawn   Jul-10-05 10:20 AM   #18 
  - ...was found to have made up two families ... in grant applications  LeighAnn   Jul-10-05 10:58 AM   #24 
  - Lyme Disease was the pilot project for bogus research  preciousdove   Jul-10-05 11:09 AM   #27 
  - I'd throw his ass in the gulag if I had my way  DS1   Jul-10-05 11:20 AM   #29 
  - It's simple to falsify data.  igil   Jul-10-05 11:36 AM   #32 
  - I'm sure the White House would be happy to employ Dr. Friedman. eom  Straight Shooter   Jul-10-05 12:03 PM   #37 
  - i saw fellow grad students do it in the '70s-80's often  kodi   Jul-10-05 04:38 PM   #47 

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