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Reply #66: Thanks for the info...I wonder about their assays... [View All]

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Sufi Marmot Donating Member (1000+ posts) Send PM | Profile | Ignore Tue Mar-29-05 03:45 PM
Response to Reply #58
66. Thanks for the info...I wonder about their assays...
To provide a perspective for interpreting antibody seropositivity rates for persons having contact with monkeys (or monkey body fluids or tissues), serum specimens from 449 persons from throughout the United States randomly selected from a cross-sectional adult primary-care outpatient population were tested by the same IFA and Western blot assays. Of these, 12 (2.7%) were positive. Reported by: Special Pathogens Br and Epidemiology Activity, Div of Viral and Rickettsial Diseases, Center for Infectious Diseases, CDC....The background seropositivity rate for persons from throughout the United States chosen randomly from an adult primary-care outpatient population remains unexplained. One possibility is antigenic crossreactivity between the known filoviruses and another, as yet undetermined, antigen. Further investigations are in progress to clarify this. Investigations are also in progress to define risk factors for occupationally acquired infection and to assess the risk for infection of household contacts of infected persons.

I wonder just how specific the antibodies they used here were, if they're lighting up people who have supposedly never been exposed to filoviruses. I also wonder if the Reston workers were somehow exposed only to filovirus proteins or "dead" virus particles, and not live ones.

-SM
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  - Marburg in Angola is a Recombinant  pandemic_1918   Apr-02-05 07:08 PM   #75 
     - Is there any hard evidence, or is this just conjecture on your part?  Sufi Marmot   Apr-02-05 08:02 PM   #76 
        - I would also like to know . .  sharonking21   Apr-03-05 04:17 PM   #77 
           - Has filovirus recombination ever been documented?  Sufi Marmot   Apr-03-05 05:52 PM   #78 
  - Scary Stuff!  GOPFighter   Mar-22-05 02:40 PM   #6 
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  - No time to spread . . .  DrRang   Mar-24-05 07:12 AM   #13 
  - They're self-limiting  frustrated_lefty   Mar-24-05 08:19 AM   #15 
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     - Exactly why AIDS is so dangerous.  Willy Lee   Mar-28-05 02:07 PM   #54 
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  - NPR doesn't have much credibility with me since....  Media_Lies_Daily   Mar-28-05 02:03 PM   #52 
  - pandemic_1918  Moderator   Mar-25-05 10:43 AM   #17 
  - kick to combine  Moderator   Mar-27-05 09:41 PM   #20 
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  - Truly frightening...  etherealtruth   Mar-27-05 09:41 PM   #22 
  - Getting involved for humanitarian reasons  CC   Mar-27-05 09:41 PM   #23 
  - Travel of virus  sharonking21   Mar-27-05 09:41 PM   #26 
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  - No, not in comparison with flu or colds, etc  sharonking21   Mar-27-05 09:41 PM   #31 
  - Didn't the Reston workers test positive for simian Ebola antibodies?  Sufi Marmot   Mar-27-05 11:32 PM   #48 
     - Yes re: Reston  sharonking21   Mar-29-05 03:26 AM   #58 
        - Thanks for the info...I wonder about their assays...  Sufi Marmot   Mar-29-05 03:45 PM   #66 
           - I noticed that  sharonking21   Mar-29-05 04:40 PM   #67 
  - Possible...  xpunkisneatx   Mar-27-05 10:27 PM   #44 
     - Mutation rate?  sharonking21   Mar-29-05 03:32 AM   #59 
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     - Marburg Virus Transmission in Angola Capital of Luanda?  norml   Mar-27-05 09:41 PM   #40 
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  - Marburg Hemorrhagic Fever  norml   Mar-27-05 09:41 PM   #25 
  - Barrier methods  sharonking21   Mar-27-05 09:41 PM   #27 
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  - The case-fatality rate for Marburg hemorrhagic fever is between 23-25%.  norml   Mar-27-05 09:41 PM   #30 
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  - Heh, I know this is a serious subject but...  IMayBeWrongBut   Mar-27-05 09:41 PM   #34 
  - LMAO!  there-s a   Mar-28-05 09:05 AM   #50 
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  - I don't know where you got that info...  xpunkisneatx   Mar-27-05 10:30 PM   #45 
  - Case Fatality Rates that Differ by Outbreak  sharonking21   Mar-29-05 03:18 AM   #57 
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  - 3-9 Day Incubation Period  pandemic_1918   Mar-27-05 09:41 PM   #35 
     - I read elsewhere that the incubation is 21 days???????????  POAS   Mar-27-05 09:41 PM   #37 
        - Did some digging and found this  POAS   Mar-27-05 09:41 PM   #38 
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  - Global Potential Lake Victoria Marburg Virus Code Red Alert  norml   Mar-27-05 09:41 PM   #43 
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     - See this comment above  sharonking21   Mar-29-05 10:29 AM   #60 
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  - kick to combine  Moderator   Apr-03-05 10:27 PM   #79 
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     - Marburg Spread Accelerating  pandemic_1918   Apr-04-05 03:43 PM   #82 
  - List of Books on Epidemics and Outbreaks  sharonking21   Apr-05-05 11:27 PM   #83 
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  - Updates, questions of Marburg Outbreak in Angola  sharonking21   Apr-08-05 04:56 AM   #86 
 

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