KC, Columbia, and St. Louis are solidly blue and a few of the college towns (including where I live) can flip on occasion. It's more Springfield and the bootheel that are deep red.
FWIW-everyone here has dismissed us as going red in the next election. Personally, I think it'll be more purple, yet again. It's going to be a close race, as long as the GOP offers no other candidates. And if the Dems find a decent candidate for the Fourth it'll go dark blue for that candidate-everyone hates Hartzler around here!