HomeLatest ThreadsGreatest ThreadsForums & GroupsMy SubscriptionsMy Posts
DU Home » Latest Threads » Forums & Groups » Main » Latest Breaking News (Forum) » Venezuela to probe Chavez... » Reply #122

Response to Zorro (Original post)

Sat Mar 16, 2013, 03:46 PM

122. SV-40 Virus


The SV40 is a type of polyoma virus. The term “poly” means many and “oma” means tumor. Its very name designates its ability to cause many types of cancers. The specific biological mechanisms by which SV40 transforms (turns cancerous) cells have been well studied since its discovery in the early 1960’s. In fact, there are volumes of scientific publications on this subject. Below is a brief outline of some of the mechanisms. Supporting documentation can be found through Medline by simply entering the term SV40 with the appropriate mechanism.
1. Telomerase activity
The telomere is a repetitive stretch of DNA found at each end of a chromosome. Telomeres are shortened each time a cell divides. This is the reason that normal cells can only divide roughly 50 times. An enzyme, telomerase, extends the telomere. Tumors cells often have telomerase activity which allows the cancer cells to divide without limit. SV40 infection leads to telomerase activity.
2. Binding to and inhibition of cellular p53 and retinoblastoma (RB) proteins
The p53 gene and the retinoblastoma (Rb) gene are tumor suppressor genes. They promote cell-cycle arrest (stop cells from dividing) when the cells are injured or damaged. Their ability to function properly is critical because their respective proteins stop the formation of tumors. The major SV40 oncoprotein is the Large tumor antigen (Tag). Tag binds to and inactivates cellular p53 and Rb. Therefore, the presence of SV40 stops these tumor suppressor genes from doing their job.
3. Inhibition of protein phosphatase 2A (PP2A)
Protein Phosphatase 2A (PP2A) plays a role in the critical cellular processes of protein synthesis, DNA replication, transcription, and metabolism. Small t antigen of SV40 comprises 174 amino acids. The region between residues 97-103 interacts with the PP2A. This interaction reduces the ability of PP2A to inactivate ERK1 and MEK1 protein kinases, resulting in stimulation of proliferation of cells.

--snip--

More at the link:http://www.sv40foundation.org/How-causes.html

Reply to this post

Back to OP Alert abuse Link to post in-thread

Always highlight: 10 newest replies | Replies posted after I mark a forum
Replies to this discussion thread
Arrow 173 replies Author Time Post
Zorro Mar 2013 OP
msongs Mar 2013 #1
Drale Mar 2013 #2
Coyotl Mar 2013 #101
Drale Mar 2013 #108
Exultant Democracy Mar 2013 #113
Bradical79 Apr 2013 #161
Exultant Democracy Apr 2013 #169
Bradical79 Apr 2013 #171
Ken Burch Apr 2013 #173
Submariner Mar 2013 #3
RKP5637 Mar 2013 #4
RZM Mar 2013 #13
geek tragedy Mar 2013 #5
Duer 157099 Mar 2013 #10
geek tragedy Mar 2013 #12
reorg Mar 2013 #17
geek tragedy Mar 2013 #18
reorg Mar 2013 #21
geek tragedy Mar 2013 #22
reorg Mar 2013 #23
geek tragedy Mar 2013 #24
reorg Mar 2013 #25
geek tragedy Mar 2013 #26
reorg Mar 2013 #49
geek tragedy Mar 2013 #50
reorg Mar 2013 #58
geek tragedy Mar 2013 #59
reorg Mar 2013 #63
geek tragedy Mar 2013 #64
reorg Mar 2013 #91
mikeysnot Mar 2013 #71
Ken Burch Mar 2013 #131
geek tragedy Mar 2013 #132
geek tragedy Mar 2013 #19
Duer 157099 Mar 2013 #65
geek tragedy Mar 2013 #66
Duer 157099 Mar 2013 #67
geek tragedy Mar 2013 #69
Duer 157099 Mar 2013 #73
geek tragedy Mar 2013 #74
Duer 157099 Mar 2013 #81
geek tragedy Mar 2013 #83
Duer 157099 Mar 2013 #85
geek tragedy Mar 2013 #86
Duer 157099 Mar 2013 #87
geek tragedy Mar 2013 #90
COLGATE4 Mar 2013 #27
Duer 157099 Mar 2013 #68
Dash87 Apr 2013 #153
reorg Mar 2013 #89
geek tragedy Mar 2013 #92
reorg Mar 2013 #94
geek tragedy Mar 2013 #95
reorg Mar 2013 #96
Coyotl Mar 2013 #102
geek tragedy Mar 2013 #106
Archae Mar 2013 #6
mikeysnot Mar 2013 #7
geek tragedy Mar 2013 #8
mikeysnot Mar 2013 #29
geek tragedy Mar 2013 #30
mikeysnot Mar 2013 #33
geek tragedy Mar 2013 #34
mikeysnot Mar 2013 #37
geek tragedy Mar 2013 #39
mikeysnot Mar 2013 #47
geek tragedy Mar 2013 #48
mikeysnot Mar 2013 #55
geek tragedy Mar 2013 #61
mikeysnot Mar 2013 #70
geek tragedy Mar 2013 #72
mikeysnot Mar 2013 #75
geek tragedy Mar 2013 #78
mikeysnot Mar 2013 #79
geek tragedy Mar 2013 #84
mikeysnot Mar 2013 #99
cstanleytech Mar 2013 #100
mikeysnot Mar 2013 #104
cstanleytech Mar 2013 #115
mikeysnot Mar 2013 #117
cstanleytech Mar 2013 #119
mikeysnot Mar 2013 #121
cstanleytech Mar 2013 #124
mikeysnot Mar 2013 #125
cstanleytech Mar 2013 #127
mikeysnot Mar 2013 #128
mikeysnot Mar 2013 #118
cstanleytech Mar 2013 #120
mikeysnot Mar 2013 #126
cstanleytech Mar 2013 #129
mikeysnot Mar 2013 #133
cstanleytech Mar 2013 #134
mikeysnot Mar 2013 #137
cstanleytech Mar 2013 #140
mikeysnot Mar 2013 #142
cstanleytech Mar 2013 #144
mikeysnot Apr 2013 #147
cstanleytech Apr 2013 #148
cstanleytech Apr 2013 #149
mikeysnot Apr 2013 #150
cstanleytech Apr 2013 #152
mikeysnot Apr 2013 #155
cstanleytech Apr 2013 #156
mikeysnot Apr 2013 #160
cstanleytech Apr 2013 #165
mikeysnot Apr 2013 #167
mikeysnot Apr 2013 #157
cstanleytech Apr 2013 #158
mikeysnot Apr 2013 #159
Bay Boy Mar 2013 #105
geek tragedy Mar 2013 #107
Bay Boy Mar 2013 #112
geek tragedy Mar 2013 #114
Ghost Dog Mar 2013 #136
mikeysnot Mar 2013 #143
naaman fletcher Apr 2013 #151
cstanleytech Mar 2013 #9
geek tragedy Mar 2013 #20
Archae Mar 2013 #11
Coyotl Mar 2013 #109
hrmjustin Mar 2013 #14
musical_soul Mar 2013 #15
davidpdx Mar 2013 #16
mikeysnot Mar 2013 #32
davidpdx Mar 2013 #97
mikeysnot Mar 2013 #98
tblue Mar 2013 #110
Cal Carpenter Mar 2013 #28
geek tragedy Mar 2013 #31
mikeysnot Mar 2013 #35
geek tragedy Mar 2013 #36
mikeysnot Mar 2013 #38
geek tragedy Mar 2013 #40
Cal Carpenter Mar 2013 #41
geek tragedy Mar 2013 #43
Cal Carpenter Mar 2013 #44
geek tragedy Mar 2013 #45
mikeysnot Mar 2013 #56
geek tragedy Mar 2013 #60
Nye Bevan Mar 2013 #42
geek tragedy Mar 2013 #46
COLGATE4 Mar 2013 #51
geek tragedy Mar 2013 #52
yurbud Mar 2013 #53
mikeysnot Mar 2013 #57
geek tragedy Mar 2013 #62
mikeysnot Mar 2013 #76
yurbud Mar 2013 #77
mikeysnot Mar 2013 #80
geek tragedy Mar 2013 #82
yurbud Mar 2013 #88
geek tragedy Mar 2013 #93
Brayshawna Williams Mar 2013 #54
Coyotl Mar 2013 #103
tblue Mar 2013 #111
Judi Lynn Mar 2013 #116
LineReply SV-40 Virus
formercia Mar 2013 #122
Ghost Dog Mar 2013 #135
Ghost Dog Mar 2013 #138
formercia Mar 2013 #139
Judi Lynn Mar 2013 #141
formercia Mar 2013 #146
Ghost Dog Apr 2013 #170
Bradical79 Apr 2013 #166
formercia Apr 2013 #168
Bradical79 Apr 2013 #172
jzodda Mar 2013 #123
nomorenomore08 Mar 2013 #130
Socal31 Mar 2013 #145
Pterodactyl Apr 2013 #154
Travelman Apr 2013 #162
MADem Apr 2013 #164
MADem Apr 2013 #163
Please login to view edit histories.