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hedgehog

Profile Information

Gender: Female
Hometown: Oswego County, New York
Home country: USA
Current location: Lake Ontario Snow Belt
Member since: Fri Apr 23, 2004, 11:56 PM
Number of posts: 34,539

About Me

I've been a female working a "man's job" (mechanical engineer), stay at home Mom (6 kids), working Mom (6 kids to put through college), unemployed, underemployed, temporarily employed and now working from home! We live on an old, small farm with 2 dogs and 2 cats in the house, variable number of chickens out in the yard.

Journal Archives

Here's some info on Ibupropen I'd like to hear some comments on:

My doctor wants me to limit my ibupropen because of fear of kidney damage. Sure enough, i can point you to dozens of posting from newspapers and reputable web sites that repeat that warning. But sometimes, ibupropen is the only thing that controls my pain.

So , digging down in Google, I finally found this:

"All NSAIDs can produce a variety of adverse effects on the kidney. While there is little threat of renal insult with NSAIDs in normal, healthy individuals, risks may be increased in the elderly, in those who are dehydrated, and in those with underlying renal disease. The risk of certain types of renal toxicity may increase with the dose and duration of NSAID use.

Almost three decades of postmarketing experience with prescription-strength ibuprofen in the United States and worldwide, during which over 100 billion doses have been administered, has shown the frequency of renal side effects to be low. Post marketing experience with non-prescription ibuprofen confirms its safety in the general population. Safety data from controlled clinical trials add further assurance that non-prescription doses of ibuprofen are well tolerated by the kidneys.

The foregoing publicly-available information has been extracted from the original Citizen’s Petition to request monograph status for ibuprofen (July 1997), and two updates (through 2001). The published OTC experience of ibuprofen during the past 18 years is consistent with a very safe profile with respect to the renal system. Despite the National Kidney Foundation’s first consensus statement published in 1984, a more recent statement in 1996, and a public FDA feedback meeting on the subject, the dire renal consequences which were forecasted with the OTC availability and use of ibuprofen have not materialized. When used as directed, the potential of OTC ibuprofen to cause renal problems is extremely low. "

http://www.fda.gov/ohrms/dockets/ac/02/briefing/3882b2_04_wyeth-ibuprophen.htm


and while the Kidney people warn against it, the Cystic Fibrosis people recommend it:

There has been some concern that ibuprofen can cause kidney damage. This can occur, but it is unlikely. Scientists know that ibuprofen decreases blood flow to the kidneys and slows down the kidneys’ ability to clear out other drugs. Your CF doctor may need to adjust the doses of other drugs you or your child are taking. Other side effects are more unusual or less severe. Ask your CF doctor about these other side effects of ibuprofen.


http://www.cff.org/treatments/Therapies/Respiratory/Ibuprofen/

Good news/bad news about the dog I'm babysitting.

Good news: Biscuit is no longer afraid of the dog door.

Bad news: He chases the little cat when she comes into the house through the dog door.

(we have an outside pen with a chain link fence that keeps the dogs in, but allows the cats through the corner gaps to roam the yard.

Does anyone make a good looking women's shoe that actually fits and is comfortable?

(I just found this group, so please forgive me if this has already been asked and answered.)

According to the Brannock device, I wear a 7 1/2 C; I've been buying 8 1/2 D

Except - even if the toe box fits, the heel slips off my foot or I end up stepping right out of the shoes because of my high arches.

I'm 60 years old, isn't there naything other than Mary Janes or (ahem) "old lady shoes" that will fit my feet?

Top it off - some of my shoes are now too tight in the toe box and still slipping off my heels!

I was wrong -

Last August I posted a comment speculating that if enough humans were infected with Ebola, and one particular virus mutated the right way, then we would end up dealing with airborne Ebola.

I was wrong. I have since learned that given the structure of Ebola, chances of it mutating to an airborne form are about as likely as a puppy being born with wings.

"The question often asked is whether Ebola could evolve to spread through the air in dried particles, entering the body along a pathway into the lungs. Eric Lander, the head of the Broad Institute, thinks that this is the wrong question to ask. Lander is tall, with a square face and a mustache, and he speaks rapidly and with conviction. “That’s like asking the question ‘Can zebras become airborne,’ ” he said. In order to become fully airborne, Ebola virus particles would need to be able to survive in a dehydrated state on tiny dust motes that remain suspended in the air and then be able to penetrate cells in the lining of the lungs. Lander thinks that Ebola is very unlikely to develop these abilities. “That would be like saying that a virus that has evolved to have a certain life style, spreading through direct contact, can evolve all of a sudden to have a totally different life style, spreading in dried form through the air. A better question would be ‘Can zebras learn to run faster?’ ”

http://www.newyorker.com/magazine/2014/10/27/ebola-wars?intcid=mod-most-popular

A new article on Ebola by Richard Preston, author of The Hot Zone:

http://www.newyorker.com/magazine/2014/10/27/ebola-wars?intcid=mod-most-popular

Is there any way The Walking Dead ends well?

Dog doors: we're babysitting a friend's young dog, but we're having trouble getting

across the concept of the dog door. Our two dogs hop in and out with ease, and this fellow will put his head through, but he doesn't like using it. He was a rescue dog just homed a month or so back, so I don't know his early history.

Any advice?

My pharmacist is not worried about Ebola, he's worried about this:

Rapid Price Increases for Some Generic Drugs Catch Users by Surprise

Large price increases in the United States for vital medicines for the young, such as vaccines, have been mirrored by similar rises in some of the most basic treatments for older patients, like digoxin. Though there are many newer types of drugs to treat heart disease, for some patients there are no effective substitutes; digoxin is on the World Health Organization’s list of essential medicines.

In recent years, generics have curbed the rise of drug prices, saving the American health care system billions of dollars. After the patents for Lipitor, the cholesterol drug, and Ambien, the sleeping pill, expired in the last few years, for example, generics entered the market and prices plummeted.

But increasingly, experts say, the costs of some generic drugs are going the other way. The prices paid by pharmacies for some generic versions of Fiorinal with codeine (for migraines) and Synthroid (a thyroid medicine) as well as the generic steroid prednisolone have all more than doubled since last year, EvaluatePharma found. In January, the National Community Pharmacists Association called for a congressional hearing on generic drug prices, complaining that those for many essential medicines grew as much as “600, 1,000 percent or more” in recent years. The price jumps especially affected smaller pharmacies, which do not have the clout of big chains to bargain for discounts.

http://www.nytimes.com/2014/07/09/health/some-generic-drug-prices-are-soaring.html?_r=0

An older story, but one that is still relevant.

Much of the panic over Ebola is generated by information originally in the book,

The Hot Zone, by Richard Preston,

http://en.wikipedia.org/wiki/The_Hot_Zone

which was written in 1994 as a non-fiction thriller. He went on to write a fictional account of a bio weapon, Cobra Event and a non-fiction discussion of smallpox, The Demon in the Freezer. I read these books and interpreted them as an attempt to alert people to the need to have a well funded government agency studying emerging diseases and preparing against bio-warfare. It was to Mr. Preston's advantage to select the most horrifying facts to make his point. (Not that there is anything wrong or unusual with that - look at other recent books by other authors about say, the meat packing industry.) The film Outbreak was loosely based on the Hot Zone and of course we've had the recent movie Contagion as well.

That said, Mr. Presto's book was written in 1994. Here is a cell phone from 1994:



I would suggest that the information in The Hot Zone does not reflect the results of the 20 years of research since it was published.

We're fighting Ebola here because Republicans cut the budget for fighting it there.

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