Mon Dec 12, 2011, 05:10 AM
RainDog (27,410 posts)
Early Studies Indicate Cannabis May Shrink Tumor Cells (Studies: 1974-2010)
Last edited Mon Dec 12, 2011, 11:27 PM - Edit history (1)
Project Censored, Top 25 Stories, 2001: http://www.projectcensored.org/top-stories/articles/22-us-government-repressed-marijuana-tumor-research/
The U.S. Government Attempted to Repress the Marijuana Cancer Research Going Back to 1974
...The Madrid researcher (studying the tumor-reducing qualities of cannabinoids, noted in the post immediately below) said he had heard of the Virginia study, but had never been able to locate literature on it. “I am aware of the existence of that research. In fact I have attempted many times to obtain the journal article on the original investigation by theses people, but it has proven impossible,” Guzman said. His response wasn’t surprising, considering that in 1983 the Reagan/Bush administration tried to persuade American universities and researchers to destroy all 1966/76 cannabis research work, including compendiums in libraries, reports Jack Herer. “We know that large amounts of information have since disappeared,” he says.
From the Journal of of the National Cancer Institute, 1975. (hosted via UKCIA): http://www.ukcia.org/research/AntineoplasticActivityOfCannabinoids/index.php
Furthermore, Nahas et al. (7) showed that in chronic marihuana users there is a decreased lymphocyte reactivity to mitogens as measured by thymidine uptake. These and other (8) observations suggest that marihuana (delta-9-THC) interferes with vital cell biochemical processes, though no definite mechanism has yet been established. A preliminary report from this laboratory (9) indicated that the ability of delta-9-THC to interfere with normal cell functions might prove efficacious against neoplasms. This report represents an effort to test various cannabinoids in several in vivo and in vitro tumor systems to determine the kinds of tumors that are sensitive to these compounds and reveal their possible biochemical sites of action(s).
Researchers at Harvard published a study in 2007 that indicates cannabis cuts lung cancer tumors by 50%. http://www.sciencedaily.com/releases/2007/04/070417193338.htm
They say this is the first set of experiments to show that the compound, Delta-tetrahydrocannabinol (THC), inhibits EGF-induced growth and migration in epidermal growth factor receptor (EGFR) expressing non-small cell lung cancer cell lines. Lung cancers that over-express EGFR are usually highly aggressive and resistant to chemotherapy.
Research in Spain, published in 2009, demonstrated the mechanism by which cannabis induces cancer cell death: http://www.jci.org/articles/view/37948
Δ-Tetrahydrocannabinol (THC), the main active component of marijuana (7), exerts a wide variety of biological effects by mimicking endogenous substances — the endocannabinoids — that bind to and activate specific cannabinoid receptors (8). One of the most exciting areas of research in the cannabinoid field is the study of the potential application of cannabinoids as antitumoral agents (9). Cannabinoid administration has been found to curb the growth of several types of tumor xenografts in rats and mice (9, 10).
California Breast Cancer Research Program (from Molecular Cancer Therapeutics): Inhibition of Breast Cancer Aggressiveness by Cannibidiol: http://www.cbcrp.org/research/PageGrant.asp?grant_id=4903
Combining Cannabinoids Enhances Inhibition of Brain Cancer Cells: http://patients4medicalmarijuana.wordpress.com/2010/01/11/combining-marijuana-components-enhances-inhibitory-effects-on-brain-cancer-2/
The study was done at the California Pacific Medical Center by researchers who combined a non-psychoactive ingredient of marijauna, cannabidiol (CBD), with Δ9-tetrahyrdocannabinol (Δ9-THC), the primary psychoactive ingredient in Cannabis. The findings demonstrated the inhibitory effect of these two ingredients on brain cancer cells when used together.
pretty interesting research, huh?
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