HomeLatest ThreadsGreatest ThreadsForums & GroupsMy SubscriptionsMy Posts
DU Home » Latest Threads » Forums & Groups » Topics » Health » Health (Group) » Tests in Mice Misled Rese...

Mon Feb 11, 2013, 08:56 PM

Tests in Mice Misled Researchers on 3 Diseases, Study Says

By GINA KOLATA
Published: February 11, 2013


For decades, mice have been the species of choice in the study of human diseases. But now, researchers report evidence that the mouse model has been totally misleading for at least three major killers — sepsis, burns and trauma. As a result, years and billions of dollars have been wasted following false leads, they say.

The study’s findings do not mean that mice are useless models for all human diseases. But, its authors said, they do raise troubling questions about diseases like the ones in the study that involve the immune system, including cancer and heart disease.

“Our article raises at least the possibility that a parallel situation may be present,” said Dr. H. Shaw Warren, a sepsis researcher at Massachusetts General Hospital and a lead author of the new study.

The paper, published Monday in Proceedings of the National Academy of Sciences, helps explain why every one of nearly 150 drugs tested at a huge expense in patients with sepsis has failed. The drug tests all were based on studies in mice. And mice, it turns out, can have something that looks like sepsis in humans, but is very different from the condition in humans.

more

http://www.nytimes.com/2013/02/12/science/testing-of-some-deadly-diseases-on-mice-mislead-report-says.html

3 replies, 971 views

Reply to this thread

Back to top Alert abuse

Always highlight: 10 newest replies | Replies posted after I mark a forum
Replies to this discussion thread
Arrow 3 replies Author Time Post
Reply Tests in Mice Misled Researchers on 3 Diseases, Study Says (Original post)
n2doc Feb 2013 OP
zazen Feb 2013 #1
undergroundpanther Feb 2013 #2
SheilaT Feb 2013 #3

Response to n2doc (Original post)

Mon Feb 11, 2013, 09:06 PM

1. burning mice for experimentation? we're a monstrous species n/t

Reply to this post

Back to top Alert abuse Link here Permalink


Response to n2doc (Original post)

Mon Feb 11, 2013, 09:54 PM

2. animals are not humans

their bodies are different than ours.If you want to know how medications or diseases work in humans...use humans.

I wonder how much medical fuck ups have occurred because of other species bodies being used as if they were models for our bodies? I wonder how much faster cures could be found if humans were asked and consented to and were compensated for being test subjects? Universal healthcare would ensure test subjects would not suffer years later from unintended consequences of a medical test years after the test.

I know there are people who would volunteer if they knew any health problems that occur later from being a test subject were covered.

Reply to this post

Back to top Alert abuse Link here Permalink


Response to n2doc (Original post)

Tue Feb 12, 2013, 01:42 AM

3. I have also long had serious doubts about

the animal models when doing medical research. How often is some discovery involving an animal then touted as "THIS will be the cure" for whatever. And then, when they actually test on humans, it's meh.

I do clearly understand that there have to be lots of precautions about testing on real humans, but there still needs to be a better way, than getting our hopes up with what in the end are meaningless test results.

Reply to this post

Back to top Alert abuse Link here Permalink

Reply to this thread