Thu Jan 24, 2013, 09:02 AM
2on2u (1,843 posts)
Cruciferous vegetables and estrogen metabolism
This discussion thread was locked as off-topic by MineralMan (a host of the Health group).
Introduction: Dietary Ingredients Improve Estrogen Metabolism
Though discovered over ten years ago, the connection between plant-derived dietary ingredients and estrogen is just beginning to be appreciated. This connection has the power to explain much of the mystery of why people living in developed nations, but lacking dietary "phytonutrients", suffer disproportionately from the major hormone dependent cancers, colon cancer, and coronary heart disease.1 H. Leon Bradlow, Ph.D. and his group at the Strang Cancer Prevention Laboratory in New York were the first to establish the link between phytonutrients from cruciferous vegetables and estrogen metabolism. 2 They showed that supplemental use of a single cruciferous phytochemical can act to promote a dramatic and beneficial change in the metabolism of estrogen.3 This change in metabolism has the power to greatly reduce estrogen exposure as a risk for cancer.
This discovery proved that the metabolism and growth promoting activity of estrogen is modified by the intake of milligram amounts of dietary indoles from crucifers. When these cruciferous phytochemicals are added to the diet, estrogen action is regulated and its metabolism is shifted. This produces a predominance of 2-hydroxy and 2-methoxyestrogens. 4 These active metabolites have been called "good estrogens" 5, function as antioxidants 6, and have the power to eliminate damaged or cancerous cells throughout the body 7. Without these phytochemicals in the diet, there is increased production of a different, undesirable group of estrogen metabolites. These so-called "bad estrogens" act negatively to allow oxidation, to damage DNA, and to promote cancer 8.
A diet-derived imbalance in estrogen metabolism explains epidemiology showing a high prevalence of estrogen related disease, especially breast cancer, in societies consuming a diet low in total vegetable content.9 Supplemental use of diindolylmethane (DIM), the most active cruciferous indole, can restore and maintain a favorable balance of estrogen metabolites. Supplementation with DIM provides an innovative approach to reducing the estrogen-related risk of breast cancer. Therefore, DIM supplementation can increase the safety of estrogen replacement therapy in post menopausal women. In addition, aging-related alteration in estrogen metabolism is an under appreciated factor in men's health. DIM use by men promotes the same beneficial estrogen metabolism as seen in women. Improving estrogen balance in men may serve as a basis for enhancing prostate health.10
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Cruciferous vegetables and estrogen metabolism (Original post)
Response to 2on2u (Original post)
Thu Jan 24, 2013, 11:45 AM
MineralMan (76,284 posts)
1. Warning: People on blood-thinners should not consume
cruciferous vegetables without consulting their physician!
This OP is bad advice, because it is based on a lack of knowledge of drug interactions. The effects of following this advice for people taking heparin or another clot-prevention medication could be fatal. This is why threads on supplements are such a bad idea on a site like DU. They are generally posted by people who do not have sufficient medical education to know when the advice may be potentially dangerous to some people.
For that reason, I am locking this thread as a host in the Health Group.
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