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Mon Aug 6, 2012, 07:56 AM

White Blood Cells Mediate Insulin Resistance: Neutrophils' Role Is a Surprise

http://www.sciencedaily.com/releases/2012/08/120805144841.htm

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This is a false-colored, scanning electron micrograph of a neutrophil. (Credit: UC San Diego School of Medicine)

ScienceDaily (Aug. 5, 2012) Researchers at the University of California, San Diego School of Medicine say neutrophils, an abundant type of white blood cell typically tasked with attacking bacteria and other foreign invaders, also plays an unexpected role in mediating insulin resistance -- the central characteristic of type 2 diabetes, which afflicts an estimated 26 million Americans.

he findings are published in the August 5, 2012 Advance Online Publication of Nature Medicine.

Neutrophils are the first immune cells to respond to tissue inflammation, and can promote chronic inflammation by summoning other white blood cells called macrophages. Chronic low-grade inflammation -- common in adipose or fat tissue -- is an important cause of systemic insulin resistance.

Using liver and fat cells from mice and humans and live mouse models, a team led by Jerrold M. Olefsky, MD, associate dean for scientific affairs at UC San Diego Health Sciences and professor of medicine, discovered that an enzyme secreted by neutrophils called neutrophil elastase (NE) impairs insulin signaling and boosts resistance. Conversely, deletion of NE in obese mice fed a high-fat diet improved insulin sensitivity

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Reply White Blood Cells Mediate Insulin Resistance: Neutrophils' Role Is a Surprise (Original post)
xchrom Aug 2012 OP
postulater Aug 2012 #1
HuckleB Aug 2012 #2
xchrom Aug 2012 #3
HuckleB Aug 2012 #4
xchrom Aug 2012 #5
HuckleB Aug 2012 #6

Response to xchrom (Original post)

Mon Aug 6, 2012, 02:25 PM

1. Thanks, didn't see that.

I love ScienceDaily!

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Response to xchrom (Original post)

Wed Aug 8, 2012, 07:29 AM

2. Rec.

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Response to HuckleB (Reply #2)

Wed Aug 8, 2012, 07:43 AM

3. where have you been?

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Response to xchrom (Reply #3)

Wed Aug 8, 2012, 10:48 AM

4. Backpacking!

It's summer! I'll be gone for the next three plus weeks, too, for the most part.

Cheers!

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Response to HuckleB (Reply #4)

Wed Aug 8, 2012, 11:57 AM

5. I am Green w/ Envy.

Tell Mom Nature we said Hi.

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Response to xchrom (Reply #5)

Wed Aug 8, 2012, 12:55 PM

6. Will do.

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